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Expected Outcome:Activities under this topic will support the EU Vision for Agriculture and Food, the EU Soil Strategy for 2030, including the implementation of the EU Soil Monitoring and Resilience Directive, the EU Adaptation Strategy, the EU Water Resilience Strategy, and the forthcoming European Climate Adaptation Plan.Project results are expected to contribute to all the following expected outcomes:enhanced monitoring of soils at subnational level (e.g. regions and municipalities) leading to an overall improved soil resilience against extreme weather events, particularly in terms of soils’ capacity to withstand and recover from floods, droughts, heatwaves and broader temperature fluctuations;tailored soil management practices and solutions that improve soil health are adopted, promoting sustainable land management, enhancing food system resilience, including food security[1], and st...

Expected Outcome: Project results are expected to contribute to all of the following outcomes:Measurable improvements in the status of critical marine and/or freshwaters habitats (including blue carbon sequestration capacities) and of species through active and passive conservation and restoration measures;Increased sustainability of fishing practices and tools and enhanced implementation of eco-system-based approaches as outlined in the Common Fisheries Policy (CFP);Measurable socio-economic benefits for local communities, skill development and job creation;Enhanced governance in the co-management of ecosystems and resources at local and basin level and overall strengthened Mission governance framework;Improved cross-border coordination in fish movement data collection and exchange. Scope:The Communication of the Commission on “A vision for agriculture and food sectors - Shaping togethe...

Expected Outcome:This topic aims at directly engaging and supporting public authorities and other relevant socio-economic actors (e.g. farmers, landowners, aquaculture producers, tourist operators, fishers, businesses, water management authorities) in addressing aquatic pollution and biodiversity loss, thereby demonstrating and accelerating the transitions needed for achieving one or several objectives of the Mission “Restore our Ocean and Waters”. The direct involvement of relevant authorities and stakeholders in the consortium is strongly encouraged.Project results are expected to contribute to all the following expected outcomes:Member States and Associated Countries are provided with cost-effective solutions to reach the targets of the Water Framework and the Marine Strategy Framework directives, the Urban Wastewater Treatment Directive, and the EU strategy for sustainable chemicals...

Expected Outcome:Activities should align with the international goals of the European Green Deal, specifically contribute to the EU soil strategy for 2030, the EU Biodiversity Strategy for 2030, the Zero Pollution Action Plan, and the proposal for a Soil Monitoring and Resilience Directive. In broader terms, the activities will also support EU’s efforts towards Ukraine's long-term reconstruction, focusing on reducing soil pollution and facilitating restoration, in line with the Ukraine Plan.Project results are expected to contribute to all the following expected outcomes:strengthened regional R&I ecosystems and enhanced capacities for participatory, interdisciplinary and transdisciplinary R&I approaches, allowing for effective cooperation between research, practice and policy to tackle soil health challenges in Ukraine arising from military actions and other indirect pressures;increased...

Expected Outcome:In support to the implementation of the EU Adaptation Strategy, the EU Mission on Adaptation to Climate change, and in particular having regard to the upcoming European Climate Adaptation Plan, project results should contribute to all of the following expected outcomes:Local climate adaptation actors, the financing sector, the public grant sector, and climate adaptation financing experience are brought to work together on making local adaptation actions financeable by combining public grant funding and private financing via bank loans and on overcoming the practical barriers on combining these and finding solutions, and specifically through demonstrating this with intermediated EIB adaptation lending.Local innovative adaptation actions (including nature-based solutions) have been implemented thanks to their financing by the combination of private financing via bank loans...

Expected Outcome:Expected results:Strengthened mutual understanding and friendship among citizens at local level;Better opportunities for citizens to experience and appreciate the added value of the EU through a grassroots, community-based approach;An increased sense of belonging to the EU;Long-lasting bond between municipalities and between citizens;Increased cross-border cooperation on similar practical issues of democratic participation between municipalities and between citizens, going beyond cultural exchanges;Increased effectiveness of prevention policies at local level aimed at preventing against domestic violence and violence against children; • Increased inclusion of marginalised communities, disadvantaged groups and groups at risk of discrimination;Improved accessibility for persons with disabilities and better inclusion in the community;Increased citizen participation in inclu...

Expected Outcome:Successful proposals will support the implementation of the EU Adaptation Strategy, the EU Mission on Adaptation to Climate Change, the European Water Resilience Strategy, the EU Preparedness Strategy and the upcoming European Climate Adaptation Plan. Proposals are expected to contribute to all of the following outcomes:Navigable inland waterways, their surroundings and related infrastructure are managed in a more integrated and sustainable manner across Europe and become more climate-resilientClimate and environmental risks to water infrastructure (e.g. droughts, flooding, slow onset events, ecological degradation and cascading and compound events) are more effectively addressed in a systemic way. Safe, efficient and reliable navigability conditions are improved.Cost-efficient and environmentally friendly measures -- especially nature-based solutions -- are identified w...

Expected Outcome:The successful proposal will support the implementation of the EU Mission on Adaptation to Climate Change and the upcoming European Climate Adaptation Plan. Projects are expected to contribute to all of the following outcomes:The methodology for identifying, selecting and consolidating global and regional reference climate data sets and scenarios is advanced and their consistent use across the EU in relation to climate adaptation is supported.Standardisation and quality of climate services across the EU are improved, and their uptake is enhanced.Climate services and best practices are used effectively to inform climate adaptation policies and decisions Scope: Rationale As climate risks intensify, the demand for tailored and effective climate services is growing. However, despite their increasing adoption, the lack of sufficient regulation can compromise quality assurance...

Expected Outcome:The successful proposal will contribute to the implementation of the EU Mission on Adaptation to Climate Change and the upcoming European Climate Adaptation Plan. Proposals are expected to contribute to all of the following outcomes:The wide range of solutions tested and deployed in the context of the Adaptation Mission and the good practices emerged in its Community of Practice are harvested, assessed, structured and systematised to support the implementation of the Mission.Regional and local authorities can access, in the local language, the latest and most actionable solutions for climate adaptation relevant to their (climatic) conditions. Adaptation solutions stemming from research and innovation are ready for replication and scale-up, contributing to the delivery of the Adaptation Mission and acceleration of adaptation efforts across Europe. Legacy of the knowledge...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Additional regional and local assets (data, models, digital twins) are made available on the DTO core infrastructure, EDITO;New digital twin applications, emphasising on regional and local conditions and addressing regional considerations, including stakeholders needs, availability of data, etc.;Enhanced digital twin regional capabilities, creating in the EU DTO core infrastructure, EDITO, the conditions to directly support policy implementation, including marine environmental policy, and Blue Economy applications which build on the regional characteristics of the sea-basin;Development of regional what-if-scenarios libraries, including confidence thresholds and related analysis, quantifying the necessary conditions to increase confidence levels, etc.;Support to monitoring and sustainable...

Expected Outcome:The Synergy action for Teaming Centres of Excellence (CoE) responds to the need to ensure the sustainability of CoE funded under the Teaming calls[1]. The establishment of CoE in Widening countries, supported by a significant investment in Horizon 2020 and Horizon Europe, has created new opportunities for scientific, societal, and economic impact. However, to fully capitalise on this investment and enhance the sustainability and international competitiveness of these CoE, it is essential to facilitate stronger collaboration and strategic joint initiatives among them.Proposals are expected to contribute to all the following outcomes:Stronger long-term collaboration among Teaming CoE through structured joint initiatives and clustering efforts to enhance mutual learning, resource sharing, and collective research and innovation capacity;Strategic transformation of R&I system...

Expected Outcome:Excellent capacities in research management are essential for institutions and national R&I systems to enhance their research excellence and capitalize on their R&I activities in a knowledge-based economy and society. The Research Management Facility aims at providing institutions in Widening countries that want to establish or upgrade their research management capacities with tailored support. The Research Management Facility also advises on an implementation strategy to introduce changes in the institutional set-up, in line with the ERA priorities. However, the action does not provide support for the implementation of the strategy.Strong research management ensures effective grant acquisition, resource allocation, compliance with funding regulations, and strategic planning. It supports high-quality research by streamlining administrative processes, facilitating interdi...

Expected Outcome:The Hop-on Facility allows for legal entities from Widening countries to join already funded Horizon Pillar II ‘main’ work programme and EIC Pathfinder collaborative R&I actions, subject to the agreement of the respective consortium and provided that legal entities from such countries are not yet participating as beneficiary, associated partner, or affiliated entity. The scheme aims to improve the inclusiveness of Horizon Europe. Selected consortia will be invited to submit a grant agreement amendment request of the eligible already funded action.Project results are expected to contribute to the following outcomes:At system level, mobilise excellence in the Widening countries, increase visibility of the beneficiaries from the widening countries, improve knowledge circulation, and boost their participation in specific thematic domains;At consortium level, open up establis...

Summary: The fiscal year 2026 (FY26) Alzheimer’s Research Program (AZRP) Transforming Research Award (TrRA) supports non-incremental, robust, well-designed research that drives transformative advancements in reducing risk and preventing the development of Alzheimer’s disease and/or Alzheimer's disease related dementias (AD/ADRD).Distinctive Features:• Applications must address at least one of the following focus areas: ○ Risk Factor Knowledge: Research that advances understanding, identification, and/or validation of risk and/or protective factors, with research outcomes/products focused on accelerating solutions. Projects may include, but are not limited to, research on environmental, epigenetic, genetic, lifestyle, occupational, or other risks not listed here. ○ Risk Reduction Solutions: Research that describes methods, technologies, and strategies that contribute to reducing risk and preventing AD/ADRD.• Clinical research is allowed, however clinical trials and animal research are prohibited.• Preliminary data are required.• Community collaboration is required for research prospectively enrolling human subjects.• Career Initiation or Transition (CIT) Partnership Option: The TrRA includes an option for more than one PI and supports both new and existing collaborative partnerships. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). If utilizing this option, at least one independent investigator must meet

Summary: The fiscal year 2026 (FY26) Alzheimer’s Research Program (AZRP) Transforming Diagnosis Award (TrDA) supports non-incremental, solutions-oriented research that reduces or overcomes important barriers to obtaining a diagnosis, meaningful disease monitoring and accurate prognosis.Distinctive Features:Clinical research is allowed, however clinical trials and animal research are prohibited. Preliminary data are required.Community collaboration is required for studies prospectively enrolling human subjects.Study Population: The AZRP encourages studies to leverage existing cohorts/datasets. Cohorts consisting of individuals 65 years or younger are also encouraged.Career Initiation or Transition (CIT) Partnership Option: The TrDA includes an option for more than one PI and supports both new and existing collaborative partnerships. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). If utilizing this option, at least one independent investigator must meet the CIT Partnership Option eligibility requirements at the time of application submission.

Summary: The fiscal year 2026 (FY26) Alzheimer’s Research Program (AZRP) Transforming Care Award (TrCA) supports clinical research or clinical trials evaluating interventions, innovations, and solutions in critical areas for dementia care for individuals with Alzheimer’s disease and Alzheimer’s disease related dementia (AD/ADRD) and their care partner(s).Distinctive Features:Clinical research and clinical trials are allowed; however, clinical trials solely testing or evaluating pharmacological interventions do not meet the intent of this funding opportunity.Studies utilizing animal models do not meet the intent of the mechanism and are not allowed.Preliminary data are required.Community collaboration is required for research prospectively enrolling human subjects.The AZRP encourages studies to leverage existing cohorts/datasets. Cohorts consisting of individuals 65 years or younger are also encouraged.Career Initiation or Transition (CIT) Partnership Option: The TrCA includes an option for more than one PI and supports both new and existing collaborative partnerships. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). If utilizing this option, at least one independent investigator must meet the CIT Partnership Option eligibility requirements at the time of application submission.

This funding opportunity announcement (FOA) encourages grant applications that support the activities of the National Primate Research Centers (NPRCs). Nonhuman primates (NHPs) are most closely related to humans, both physiologically and genetically. Therefore, NHPs are critical animal models for basic and translational research aimed at understanding human biology, both in normal and diseased states. Proper husbandry and management of NHPs require specialized physical and intellectual resources, which are most effectively and economically provided in centralized primate centers, the resources of which are made available to investigators on a national basis. The NPRCs provide these resources to investigators/grantees who utilize NHPs in biomedical research and thereby complement and help enable the missions of the NIH Institutes and Centers.

Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPORE). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. For the purpose of this FOA, a group of highly related cancers are those that are derived from the same organ system, such as gastrointestinal, neuroendocrine, head and neck, and other cancers. Other programmatically appropriate groups of cancers may include those centered around a common biological mechanism critical for promoting tumorigenesis and/or cancer progression in organ sites that belong to different organ systems. For example, a SPORE may focus on cancers caused by the same infectious agent or cancers promoted and sustained by dysregulation of a common signaling pathway. In addition, a SPORE may focus on cross-cutting themes such as pediatric cancers or cancer health disparities. The research supported through this program must be translational and must stem from research on human biology using cellular, molecular, structural, biochemical, and/or genetic experimental approaches. SPORE projects must have the goal of reaching a translational human endpoint within the project period of the grant.

The goal of the NIGMS Predoctoral Basic Biomedical Sciences Research Training Program is to develop a pool of well-trained scientists available to address the Nations biomedical research agenda. Specifically, this funding opportunity announcement provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical graduate training and mentoring that will keep pace with the rapid evolution of the biomedical research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation.

The National Heart, Lung, and Blood Institute (NHLBI) Program Project Grant (P01) supports research related to fundamental processes and diseases of the heart, blood and lymphatic vessels, lungs, and blood, including transfusion medicine, blood resources, and sleep disorders other programs including implementation science, health disparities, and translation research that address the mission of the Institute. This FOA requires a minimum of three interrelated research projects that investigate a complex biomedical theme or research question. The projects may be supported by core units, if justified, to facilitate economy of effort, space, and equipment. The NHLBI provides support for Program Project Grants (PPGs) in the belief that collaborative research efforts can accelerate the acquisition of knowledge more effectively than a simple aggregate of research projects that have no interaction or thematic integration. NHLBI is particularly interested in encouraging new scientific directions in PPGs. Use of the P01 activity code is viewed as an opportunity to attract scientists who have not traditionally been supported by the NHLBI. Further, the PPG environment presents an opportunity for emerging scientific leaders to gain insight into how to lead a successful scientific Program, and applicants will have the opportunity to include a project led by an Early Stage Investigator (ESI). All projects in the Program must be interrelated and have objectives that address a central theme within the scientific mandate of the NHLBI.

The purpose of the Resource-Related Research Projects (R24) grant is to support investigator-initiated resources designed to provide materials and services to support and advance biomedical research on a national basis. An R24 resource grant mechanism is a non-hypothesis-driven activity to provide data, materials, tools, or services that are essential to making timely, high quality, and cost-efficient progress in a field. Hypothesis-driven research applications should not be submitted in response to this program announcement but to another mechanism that encourages this type of research. The resource should be available to any qualified investigator, and should be highly quality controlled, and not duplicate resources available commercially or through other sources. Resources should be designed to provide services to the broad alcohol research community and should not be limited by any specific regional focus.

The Office of Research Infrastructure Programs (ORIP) invites grant applications from core facilities, resource centers, animal vivaria, or individual investigators of other shared resources to systematically study the roles of critical environmental extrinsic factors in biological, behavioral, and treatment studies using animal model species, with the objective of enhancing the rigor and reproducibility of animal research. The research area must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate the biological processes that impact multiple organ systems in order to align with the ORIPs NIH-wide mission and programs. The program supports the acquisition or update of modern equipment for measuring, monitoring, recording, and reporting environmental, biological or biobehavioral variables. The equipment requested must be capable of recording and reporting multiple parameters simultaneously.

This Notice of Funding Opportunity (NOFO) invites eligible academic or research institutions to apply for funding support to purchase latest scientific equipment that will enhance and modernize research-supporting operations of existing shared biomedical research facilities. Targeted are laboratory research core facilities, animal research facilities, and other similar shared-use research spaces. The goal of this NOFO is to strengthen research-auxiliary activities of biomedical research facilities and to enhance the efficiency of their operations. The NOFO does not support the purchase of scientific research instruments or their components, nor components of building-level infrastructure equipment that indirectly support research activities.

The specific purpose of this Notice of Funding Opportunity (NOFO) is to promote the development of a diverse, interdisciplinary workforce needed to conduct translational research on Alzheimer's disease and Alzheimer's-related dementias from target discovery through clinical development. This NOFO will support institutional training programs for predoctoral and postdoctoral level researchers with diverse educational backgrounds (i.e., basic biology, translational and clinical research, data science). The program invites eligible institutions to develop interdisciplinary training programs that will provide trainees with the knowledge and skills in data science, disease biology, behavioral research, and traditional and emerging drug discovery disciplines necessary to conduct rigorous and cutting-edge basic, translational, and clinical research for AD/ADRD.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research. To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: (1) Research Experiences, (2) Curriculum or Methods Development and (3) Outreach. The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer. This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers. To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences. The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills. In alignment with these goals, institutions may develop unique programs that capitalize....