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Expected Outcome:Project results are expected to contribute to some or all of the following outcomes:Critical infrastructure operators and authorities have access to efficient, adaptable, resilient and reliable tools and processes enabling or improving virtual and physical stress tests of their respective assets/ and operations;Critical entities have broader and deeper understanding of their technical and operational vulnerabilities and adaptive capabilities, improving the scenario building and stress tests exercises;Systems allowing notification and collaboration under stress conditions are available for relevant stakeholders;Critical entities are better equipped for post-incident investigations, including data collection, analysis and improved learning, management and sharing in a secure manner;Improved operational procedures including incidents management and training curricula are de...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Creation of cutting-edge tools, processes, equipment and technologies to enhance disaster and emergency response capabilities for various practitioners as well as for assets, such as vehicles, aircraft, and heavy equipment;Taking into consideration existing technologies, development of autonomous drones, robotics, and other technologies specifically designed for emergency medical response and search and rescue operations in hazardous conditions such as wildfires, earthquakes and large-scale events;Improvement of response efficiency and safety for survivors and emergency practitioners through the adoption of advanced, technology-driven solutions in disaster scenarios;Consider needs of existing EU-level capacities, emergency reserves, and stockpiling in the deployment of the assets...

Expected Outcome:Project results are expected to contribute to some or all of the following outcomes:Identification and analysis of potential new security risks related to innovative technologies being deployed in the urban and peri-urban environments;Innovative and modern tools to identify and measure changes in urban and peri-urban areas caused by the green transition, insofar as they concern security and possible resilience approaches;Verification of measures countering potential safety and security risks, hazards and challenges arising in areas hosting green technologies;Contribution to building awareness and societal acceptance for the safety and security aspects of the green transition;Impacts of incidents involving new and emerging technologies are examined, including environmental and climate risks;Security, safety and resilience aspects of the supply chains of green technologies...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Increased understanding of European policy makers, research community, biotech companies, and relevant security practitioners of the threat of bioterrorism and of synthetic biology, including a thorough lawful analysis of what needs to be monitored in this context, what needs to be regulated and how;Awareness raised within the related scientific community how research in synthetic biology can be used for malicious purposes. Scope:The rising threat of bioterrorism is driven by recent scientific advancements, notably by growing accessibility of synthetic biology, genetic engineering, related commercial services and public databases, which in turn enhance their obtainability to non-state actors and individuals with malicious intentions. The proliferation of do-it-yourself biohacking and com...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Improved skills, tools and training curricula for Police Authorities in Europe and Civil Society Organisations (or Non-Governmental Organisations) to work with at-risk groups to prevent persons from going missing. Those improved skills, tools and training curricula are to take into account European multicultural dimension, as well as legal and ethical rules of operation;Enhanced investigation tools and methodologies for Police Authorities in Europe to tackle cold cases in the context of missing persons, based on modern (forensic) technologies and criminology;Modern training curricula for Police Authorities, their improved cross-border cooperation and enhanced tools and methodologies to tackle new cases of missing persons;Enriched European common approaches applied by Police Autho...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Improved understanding of links between addictions and crime, including drivers of criminality;Innovative and effective solutions, including training curricula, for Police Authorities in Europe and relevant Civil Society Organisations (or Non-Governmental Organisations) to prevent addictions and related crimes, with a special attention to young people at risk;Evidence-based support to modernising European criminal justice system’s approach when dealing with addiction-related offenses;Novel approaches of collaboration between different stakeholders, primarily Police Authorities in Europe and Civil Society Organisations (or Non-Governmental Organisations), to increase communities’ addiction resilience, security and safety. Scope:A close and complex relationship exists between addic...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Creation of an integrated ecosystem for secure and resilient communication systems to support civil security operations across Europe;Advancement of next-generation capabilities, ensuring robust, scalable, and interoperable communication systems for critical civil security functions relevant for the future EU Critical Communication System (EUCCS). Scope:The European Union Critical Communication System (EUCCS) is a flagship initiative aiming at gradual development of a unified, secure, and interoperable communication infrastructure to support critical public safety and civil security operations across Europe. Aims to provide law enforcement, first responders, emergency services, and other critical sectors with reliable, real-time communication capabilities, even in challenging or...

Expected Outcome:Project results are expected to contribute to some or all of the following outcomes:Improved understanding of systemic vulnerabilities of critical entities including physical, digital, operational, and cross-sectoral dimensions, in the face of compound natural and human-made disaster risks;Verification of existing measures countering potential NaTech risks;Demonstration of advanced technological solutions that enhance the ability of public and private providers of critical services to prepare for, respond to, and recover from complex, multi-hazard scenarios, including cascading or hybrid NaTech events;Deployment of common platforms and operational tools for dynamic risk assessment, decision support, between public authorities, first responders, and critical infrastructure operators during disruptive events;Strengthened multi-level and cross-border cooperation frameworks...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Integrated single-hazard systems into multi-hazard next generation predictive models to assess cascading effects (e.g., heatwave, floods, droughts, landslides, heavy rain) and interactions across meteorological, geophysical, and technological hazards;Enhanced hazard forecasting and response through research on model integration and platform interoperability;Development of holistic risk and resilience metrics to support multi-hazard prevention strategies, encompassing main physical, economic and social effects;Improvement of analysis models considering evolving vulnerability state, due to cascading and cumulative effects, through numerical simulations and experimental tests, possibly also supported by AI applications;Collected reliable data (same granularity and format) and ways t...

The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Improved preparedness, evidence-based approaches and response capabilities, along with a strengthened ability to mitigate risks from diverse threats, by integrating validated disruptive technologies into real-world operations;Accelerated adoption of innovative solutions by reducing barriers through rigorous testing and validation, fostering collaboration among public authorities, industry, and researchers to align technologies with real-world needs. Scope:This topic aims to support the integration of disruptive technological innovations[1] into civil security by strengthening research and innovation activities that enhance preparedness, response capabilities, and risk mitigation. A key focus is bridging the gap between early-stage, low Technology Readiness Level (TRL) research an...

Expected Outcome:Project results are expected to contribute to some or all of the following expected outcomes:Police Authorities in Europe are equipped with specialised skills and technologies to counter an increase in illegal activities related to the climate change and the emergence of new (opportunistic) criminal patterns;Improved understanding by policymakers of the effects of climate change on law enforcement with a view of developing related effective European policies;improved knowledge of the impacts of climate change phenomena on social dynamics which can raise demands from public authorities to keep public order, moving beyond traditional perspectives about crime and terrorism. Scope:Global climate change is a megatrend expected to affect our societies over the next decade. As stated in “Germany: National interdisciplinary climate risk assessment”[1], “We are already living in...

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) along with other participating Institutes encourages submission of applications proposing to conduct secondary data analysis and integration of existing datasets and database resources, with the ultimate aim to elucidate cancer risk and related outcomes (e.g., risk prediction or reduction, survival, or response to treatment, etc.). The goal of this initiative is to address key scientific questions relevant to cancer by supporting the analysis of existing clinical, environmental, surveillance, health services, vital statistics, behavioral, lifestyle, genomic, and molecular profiles data. Applicants are encouraged to leverage and perform innovative analyses of the existing data. Applications may include new research aims that are being addressed with existing data, new or advanced methods of analyses, or novel combinations and integration of datasets that allow the exploration of important scientific questions in cancer research.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits grant applications proposing to develop innovative technologies offering new capabilities for the molecular or cellular characterization of cancer or for improved handling and quality control of biospecimens for basic, clinical, or epidemiological cancer research. The NOFO solicits R61 applications for early-stage projects proposing proof-of-concept/pilot studies to test the technical feasibility of the proposed method, tool, assay, platform, or instrument. Technologies proposed for development may have potential for widespread applicability but must be focused for this program on cancer-relevant use cases. Projects proposing to apply or use existing technologies for hypothesis-driven research where the novelty resides in the biological or clinical target/question being pursued are not responsive to this solicitation and will not be reviewed.This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites grant applications proposing exploratory research projects focused on further development and technical validation of emerging technologies offering novel capabilities for the molecular or cellular characterization of cancer or for improved handling and quality control of biospecimens used for basic, clinical, or epidemiological cancer research. This NOFO solicits R33 applications where major feasibility gaps for the technology or methodology have been overcome, as demonstrated with supportive preliminary data, but still require further development and rigorous technical validation to encourage adoption by the research community. Well-suited applications must propose the development of technologies that offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, cancer control, epidemiology. Technologies proposed for development may have potential for widespread applicability but must be focused in this proposal on cancer-relevant use cases. Projects proposing to apply or use existing technologies for hypothesis-driven research where the novelty resides in the biological or clinical target/question being pursued are not responsive to this solicitation and will not be reviewed.This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

Expected Impact:FOR ALL THREE THEMATIC PRIORITIES:Expected impact at the closure of the project (non-exhaustive list):Creation of new value chains in less developed regions and transition regions;Application and deployment of innovative technologies and solutions (new tothe region) in less developed and transition regions (innovation diffusion);Exploitation of project results;Innovative technologies tested and adopted by the market;Innovative solutions deployed improving businesses confidence, competencesand means to digitalise and grow;Contribution to digitisation and health systems transformation, through varioustypes of innovation and the supply of IT services;Uptake of technologically/economically reliable and viable solutions on themarket;Deployment of new technologies fostering the growth of Europe’s manufacturing sector;Innovative technologies adopted by SMEs;Identification of pos...

Expected Impact:FOR ALL THREE THEMATIC PRIORITIES:Expected impact at the closure of the project (non-exhaustive list): Innovative technologies tested and adopted by the market;Innovative solutions deployed improving businesses confidence, competences and means to digitalise and grow; Contribution to digitisation and health systems transformation, through various types of innovation and the supply of IT services;Uptake of technologically/economically reliable and viable solutions on the market;Deployment of new technologies fostering the growth of Europe’s manufacturing sector;Innovative technologies adopted by SMEs;Identification of possible sources of funding/funding mix, to cover the residual investment needs (public-private partnerships for the deployment of innovation, the collaboration with venture capitals, EIB group loans etc);Strengthening innovation diffusion channels;Reinforcin...

Summary: The fiscal year 2026 (FY26) Vision Research Program (VRP) Clinical Trial Award (CTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of service-connected eye injury and visual dysfunction. Research must align with at least one of the FY26 VRP Focus Areas.   Distinctive Features: ·       For interventions that require Investigational New Drug (IND)/Investigational Device Exemption (IDE) or equivalent regulatory authorizations for clinical testing, the IND/IDE application or equivalent must be submitted to the relevant Regulatory Agency by the CTA application submission deadline. In addition, applicants must provide documentation of communication from the Regulatory Agency indicating that the IND/IDE or equivalent is active/safe to proceed by March 1, 2027, in order for the CTA application to be considered for funding. Refer to Attachment 7: Regulatory Strategy for further details. ·       Scored peer review criteria include Clinical Impact; Research Strategy and Feasibility; Recruitment, Accrual, Retention; Regulatory Strategy and Transition Plan; Statistical Plan and Data Analysis; Ethical Considerations; Personnel and Communication. ·       Programmatic review criteria include adherence to the intent of the CTA, contribution to program portfolio, relative impact and relevance to military health. https://cdmrp.health.mil/pubs/press/2026/vrppreann

Summary: The fiscal year 2026 (FY26) Vision Research Program (VRP) Translational Research Award (TRA) supports translational research that transforms a promising discovery into new drugs, devices or clinical practice guidelines that are ready for definitive testing in clinical trials during or by the end of the period of performance. The TRA may be used to support preclinical studies, clinical research or a pilot clinical trial, but not a full-scale clinical trial. Research must align with at least one of the FY26 VRP Focus Areas. Distinctive Features: ·        If developing new drugs or device(s), the research team must include expertise in the regulatory approval process. ·        The TRA includes a Partnering Principal Investigator (PI) Option (PPIO) for two PIs, an Initiating PI and a Partnering PI. ·        Scored peer review criteria include Research Idea/Rationale, Research Strategy and Feasibility, Impact, Personnel and Post-Award Transition Plan. ·        Programmatic review criteria include adherence to the intent of the TRA, contribution to the VRP portfolio, relative impact and relevance to military health. ·        The VRP may share FY26 TRA applications and reviews with the National Eye Institute (NEI) for independent funding consideration. https://cdmrp.health.mil/pubs/press/2026/vrppreann

Summary: The fiscal year 2026 (FY26) Vision Research Program (VRP) Investigator-Initiated Research Award (IIRA) supports basic through early translational research that will yield highly impactful discoveries or major advancements in the research and/or patient care of eye injury and/or visual dysfunction related to military exposure. The IIRA may be used to support preclinical studies and/or clinical research. Research must align with at least one of the FY26 VRP Focus Areas. The IIRA cannot be used to support clinical trials. Distinctive Features: ·        The IIRA offers two Funding Levels to support research at different stages and the exploration/development of ideas of different maturity levels. ·        Funding Level 2 includes a Partnering Principal Investigator (PI) Option (PPIO) for two PIs, an Initiating PI and a Partnering PI. ·        Scored peer review criteria include Research Idea/Rationale, Research Strategy and Feasibility, Impact, and Personnel. ·        Programmatic review criteria include adherence to the intent of the IIRA, contribution to the VRP portfolio, relative impact, and relevance to military health. ·        The VRP may share FY26 IIRA applications and reviews with the National Eye Institute (NEI) for independent funding consideration. https://cdmrp.health.mil/pubs/press/2026/vrppreann

Summary: The fiscal year 2026 (FY26) Spinal Cord Injury Research Program (SCIRP) Clinical Trial Award (CTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of spinal cord injury (SCI).Distinctive Features: This funding opportunity contains an Early-Career Partnership Option, which allows for two Principal Investigators (PIs). If this option is selected, at least one of the named PIs must be an early-career investigator. Only the Initiating PI will submit a pre-application, but all PIs will need to submit full applications. The Partnering PI’s application is an abbreviated package specific to their distinct portion of the research project. If recommended for funding, each PI will be named on a separate award to the recipient organization(s). Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.Applications to this funding opportunity must name at least two spinal cord injury (SCI) community partners (e.g., SCI Lived-Experience Consultants, representatives of community-based organizations) who will provide advice and consultation throughout the planning and implementation of the research project.

Summary: The fiscal year 2026 (FY26) Spinal Cord Injury Research Program (SCIRP) Translational Research Award (TRA) supports translational research that will accelerate the movement of promising ideas in spinal cord injury (SCI) research into clinical applications.Distinctive Features:• This funding opportunity contains an Early-Career Partnership Option, which allows for two principal investigators (PIs). If this option is selected, at least one of the named PIs must be an early-career investigator. Only the initiating PI will submit a pre-application, but all PIs will need to submit full applications. The partnering PI’s application is an abbreviated package specific to their distinct portion of the research project. If recommended for funding, each PI will be named on a separate award to the recipient organization(s). Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.• Applications to this funding opportunity must name at least one SCI community partner (e.g., SCI Lived-Experience Consultant, representative of community-based organizations) who will provide advice and consultation throughout the planning and implementation of the research project.

Summary: The fiscal year 2026 (FY26) Spinal Cord Injury Research Program (SCIRP) Clinical Translation Research Award (CTRA) supports high-impact, new, or emerging clinical research that requires additional preliminary studies, such as feasibility, pilot, or optimization, to prepare for future larger-scale clinical trials or implementation. Primary objectives of this mechanism include:• Accelerating the translation of current and emerging techniques or interventions into clinical use by addressing specific barrier(s) to clinical success for the purpose of de-risking or informing the design of definitive trials.• Identifying the most effective diagnosis, treatment and rehabilitation options to support critical decision-making for patients, clinicians, care partners and policymakers.Distinctive Features:• This funding opportunity contains an Early-Career Partnership Option, which allows for two principal investigators (PIs). If this option is selected, at least one of the named PIs must be an early-career investigator. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.• Applications to this funding opportunity must name at least two spinal cord injury (SCI) community partners who will provide advice and consultation throughout the planning and implementation of the research project.

Summary: The fiscal year 2026 (FY26) Spinal Cord Injury Research Program (SCIRP) Investigator-Initiated Research Award (IIRA) supports studies that have the potential to make an important contribution to spinal cord injury (SCI) research, patient care and/or quality of life. May focus on any phase of research from basic through translational science, though studies that focus solely on identifying intervention targets are discouraged.Distinctive Features:• This funding opportunity contains an Early-Career Partnership Option, which allows for two Principal Investigators (PIs). If this option is selected, at least one of the named PIs must be an early-career investigator. Only the initiating PI will submit a pre-application, but all PIs will need to submit full applications. The partnering PI’s application is an abbreviated package specific to their distinct portion of the research project. If recommended for funding, each PI will be named on a separate award to the recipient organization(s). Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.

This funding opportunity announcement (FOA) encourages applications for institutional research career development (K12) programs that propose to support intensive supervised research training and career development experiences for clinician scientists (Scholars) leading to research independence in the area of substance use and substance use disorder research.