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This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents (including small molecules, biologics, and natural products).

Expected Outcome:This action will support and accelerate the development and adoption of European and international standards for quantum technologies, enhancing interoperability quality/reliability assurance, and trust in quantum systems. It will strengthen Europe's leadership in the global quantum standardisation landscape and ensure that European industrial and research priorities are well represented and integrated into emerging standards.Expected outcomes include:Delivery of concrete, EU-relevant pre-normative standards and technical specifications across quantum computing, communication, and sensing.Substantial contribution of European stakeholders, notably SMEs and start-ups in international standardisation bodies (e.g., ISO/IEC, ITU-T, ETSI), with alignment to EU industrial strategies.Promotion of cross-sectoral interoperability through standardised interfaces, control protocols,...

The objective of the Cybersecurity Innovation for Cyberinfrastructure (CICI) program is to advance scientific discovery and innovation by enhancing the security and privacy of cyberinfrastructure. CICI supports efforts to develop, deploy and integrate cybersecurity that will benefit the broader scientific community by securing science data, computation, collaborations workflows, and infrastructure. CICI recognizes the unique nature of modern, complex, data-driven, distributed, rapid, and collaborative science and the breadth of infrastructure and requirements across scientific disciplines, practitioners, researchers, and projects. CICI seeks proposals in four program areas: 1.  Usable and Collaborative Security for Science (UCSS): Projects in this program area should support novel and/or applied security and usability research that facilitates scientific collaboration, encourages the adoption of security into the scientific workflow, and helps create a holistic, integrated security environment that spans the entire scientific cyberinfrastructure ecosystem. 2.  Reference Scientific Security Datasets (RSSD): Projects in this program area should leverage instrumented cyberinfrastructure to capture metadata from scientific workflows and workloads as reference data artifacts that can help support reproducible security research, testing and evaluation. 3.  Transition to Cyberinfrastructure Resilience (TCR): Projects in this program area should improve the robustness, trustworthiness, integrity, and/or resilience of scientific cyberinfrastructure through testing, evaluation, harde...

This program seeks to prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure (CI) to enable and potentially transform fundamental science and engineering (S&E) research and education and contribute to the Nation's overall economic competitiveness and security. The goals of this solicitation are to (i) ensure broad adoption of CI tools, methods, and resources by the research community in order to catalyze major research advances and to enhance researchers’ abilities to lead the development of new CI, and (ii) integrate core literacy and discipline-appropriate advanced skills in advanced CI as well as computational and data-driven methods for advancing fundamental research, into the Nation’s undergraduate and graduate educational curriculum/instructional materials. Proposals responding to this solicitation may target one or both solicitation goals. For the purpose of this solicitation, advanced CI is broadly defined as the set of resources, tools, methods, and services for advanced computation, large-scale data handling and analytics, and networking and security for large-scale systems that collectively enable potentially transformative fundamental S&E research and education. This solicitation calls for innovative, scalable training, education, and curriculum/instructional materials—targeting one or more of the solicitation goals—to address emerging needs and unresolved bottlenecks in the S&E research workforce development, from the postsecondary level to active researchers to CI professionals...

The goal of the Medical Scientist Training Program (MSTP) is to develop a broad pool of highly trained physician-scientist leaders available to meet the needs of the Nations biomedical research agenda. Specifically, this Notice of Funding Opportunity (NOFO) provides support to eligible domestic institutions to develop and implement effective, evidence-based approaches to integrated dual-degree training leading to the award of both professional medical doctorate degrees and research doctorate degrees (Ph.D. or equivalent). With the dual qualification of rigorous scientific research and clinical practice, graduates will be equipped with the skills to develop research programs that accelerate the translation of research advances to the understanding, detection, treatment and prevention of human disease, and to lead the advancement of biomedical research. Areas of particular importance to NIGMS are the iterative optimization of MSTP training efficacy and efficiency, and fostering the persistence of MSTP alumni in research careers. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation.

The ROSS Rapid Response Program (RRP) awards one-time assistance via a cost-reimbursable grant for service coordination and limited direct services for residents of HUD-assisted housing. The RRP utilizes a simplified application process to promote local leadership and flexibility in addressing urgent social needs caused by unanticipated emergencies. Examples of these emergencies can include but are not limited to: • Natural disasters (e.g., wildfires or hurricanes) • Public health crises (e.g., gun violence, community-level contamination or environmental hazards) • Economic disruptions (e.g., closure of a major employment center that employs residents at the target site)

Expected Outcome:This action will establish a strategic European initiative to develop scalable, modular, and interoperable photonic quantum computing platforms. Proposals for this topic are expected to address and provide credible solutions to at least two major technical roadblocks currently limiting the advancement of photonic quantum computing such as:The lack of deterministic, high-efficiency photonic entanglement and loss-tolerant architectures suitable for fault-tolerant scalingThe absence of a standardised, integrated control stack combining photonic hardware, firmware, and system software with reliable benchmarking across platforms Project results are expected to contribute to the following expected outcomes:By 2028, demonstration of a photonic NISQ processor with ≥100 photonic qubits, integrating deterministic single-photon sources, low-loss waveguides, on-chip detectors, and a...

The Established Program to Stimulate Competitive Research (EPSCoR) is designed to fulfill the mandate of the National Science Foundation (NSF) to promote scientific progress nationwide. EPSCoR eligibility status is yearly updated and reported in the EPSCoR website (see EPSCoR eligibility). Through this program, NSF establishes partnerships with government, higher education, and industry that are designed to affect sustainable improvements in a jurisdiction's research infrastructure, Research and Development (R&D) capacity, and hence, its R&D competitiveness. The FEC program (formerly known as “EPSCoR Track-2 program”) builds interjurisdictional collaborative teams of EPSCoR investigators in Science, Technology, Engineering, and Mathematics (STEM) focus areas consistent with the currentNational Science Foundation Strategic Plan. Projects are investigator-driven and must include researchers from at least two EPSCoR eligible jurisdictions with complementary expertise and resources necessary to address challenges, which neither party could address as well or as rapidly independently. FEC projects have a comprehensive and integrated vision to drive discovery and build sustainable STEM capacity that exemplifies institutional, geographic, and disciplinary diversity. The projects’ STEM research and education activities seek to broaden participation through the strategic inclusion and integration of all individuals, institutions, and sectors. Additionally, EPSCoR recognizes that the development of early-career faculty is critical to sustaining and advancing research capacity.

This Notice of Funding Opportunity (NOFO) is for support of National Centers for Cryoelectron Tomography (CryoET) to provide nationwide access to advanced cryoET instrumentation and technical support, and to assist investigators in acquiring the skills needed to perform cryoET studies.

The purpose of the Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) award is to support federally recognized American Indian/Alaska Native (AI/AN) Tribes, Tribal colleges and universities, Tribal health programs, or Tribal organizations(collectively, eligible Tribal entities) to establish Institutional Review Boards (IRBs) or enhance the capacity of existing Tribal IRBs.

This Notice of Funding Opportunity (NOFO) invites applications for Diabetes Research Centers (DRCs) that are designed to support and enhance the national research effort in diabetes, its complications, and related endocrine and metabolic diseases. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P&F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in diverse perspectives, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers.

Quantum Machine Learning

Awarded activities will facilitate the translation of novel recording and modulation technologies that can be used to treat and/or diagnose central nervous system (CNS) diseases and disorders and to better understand the human CNS, from proof of concept up to the stage of readiness for first in human (FIH) studies. Technologies may incorporate any signal modality (e.g., electrical, optical, magnetic, acoustic) or a combination thereof. Diverse team-based applications that integrate appropriate domains of expertise are encouraged.

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This NOFO is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.

This Notice of Funding Opportunity (NOFO) is issued by the Food and Drug Administration (FDA), Center for Veterinary Medicine (CVM), and solicits Research Project (R01) grant applications from institutions or organizations that propose to develop or support the development of designated new animal drugs intended for minor uses in major species or for use in minor species (MUMS).  The FDA is authorized to provide grants to assist in defraying the costs of qualified safety and effectiveness testing that could be used to satisfy the requirements for FDA approval of MUMS-designated drugs. Only entities developing drugs for veterinary use or parties working as research partners with such entities are eligible for grants. The organization (or applicant) seeking approval of the new animal drug under investigation must have opened an Investigational New Animal Drug (INAD) file with FDA/CVM and must hold a minor use or minor species "designation" granted by FDA/CVM's Office of Minor Use and Minor Species Animal Drug Development (OMUMS) for that drug for a specified intended use, in accordance with the provisions of section 573 of the Food, Drug and Cosmetic Act (21 U.S.C. 360ccc-2) and 21 CFR part 516. FDA/CVM's Office of New Animal Drug Evaluation (ONADE) must have reviewed and concurred with the proposed study protocol before an applicant can submit a grant application.

Expected Outcome:Proposals should demonstrate the following expected outcomes:A sound understanding of the specific needs of industrial users (including but not limited to innovative SMEs, startups and scaleups) for Technology infrastructure services in specific priority areas including but not limited to advanced materials, clean energy, or health and biotechnology;Increased opportunities for industrial users for development, testing, up-scaling and deployment of new technologies via the use of services offered by Technology Infrastructures;Strengthened innovation and technology development capacity of European SMEs, startups and scaleups via improved access to Technology Infrastructures;Attractiveness and effectiveness of the developed access schemes for broadening the range of Technology Infrastructures users, especially for startups and scaleups, including with transnational access....

Expected Outcome:Proposals should describe a credible pathway from their project results and outcomes towards the expected impact of this Destination;Proposals should enable open-ended breakthrough innovations in industrial technologies, feeding the pipeline of knowledge. Scope:This is an open topic, intended to cover breakthrough innovations, up to TRL 4, within the scope of the Strategic Research and Innovation Agendas (SRIAs) of the partnerships Made in Europe, Process4Planet, Clean Steel, Innovative Advanced Materials for the EU (IAM4EU) and Textiles for the Future.[1] Proposals should carefully describe their expected contribution to one or more of the R&I objectives of the respective SRIA.[1] https://research-and-innovation.ec.europa.eu/funding/funding-opportunities/funding-programmes-and-open-calls/horizon-europe/european-partnerships-horizon-europe/digital-industry-and-space_en

Expected Outcome:A viable industrial ecosystem for circularity in manufacturing industries emerges, enhancing both circularity and resilience;De-manufacturing technologies and practices become available, making decisive contributions to a European remanufacturing industry and market;Functions of products are retained, reused, upgraded or adapted through de-manufacturing and re-manufacturing; andSkills, standards and safety measures relevant to remanufacturing are developed. Scope:Proposals should focus on developing de-manufacturing and re-manufacturing technologies at the factory level, addressing at least three of the following:Technologies to efficiently analyse part condition and support predictive maintenance, including for re-manufactured parts or components of lower value, e.g. by combining multimodal sensor data, AI and human inputs;AI and robotic-assisted technologies, e.g. inno...

Expected Outcome:Advanced manufacturing technology and machinery becomes available in Europe for the manufacturing of key and high-performance products;Where relevant, production becomes increasingly circular through the reuse of secondary raw materials; and/or innovative advanced materials are incorporated in manufactured products, leading to better performance and quality; Resource efficiency in terms of materials and energy is increased significantly; andCircularity, productivity and competitiveness are increased, and hence resilience of European industry is enhanced. Scope:This topic addresses technologies and machinery for advanced manufacturing, focusing on manufacturing excellence and on increasing circularity, including through the better use of innovative advanced materials and secondary raw materials. The focus is on key manufactured components and products that are competitive...

Expected Outcome:Innovative advanced materials designed for circularity are adopted in products faster, through accelerated production and technology uptake;Business models become available to enhance the use of circular advanced materials in strategic value chains; andResource efficiency (materials and energy) is increased significantly through a focus on circular advanced materials. Quality standards, harmonisation and regulatory requirements are addressed facilitating simplified market transition. Scope:The focus of this topic is on enabling circularity and resilient supply networks through R&I in advanced materials, in particular recyclable polymers and composites, magnets and metal (alloys) for additive manufacturing, and on accelerating their pathway to market. Proposals should develop new innovative advanced materials (IAMs) with superior or novel functionalities designed for circ...

Expected Outcome:Proposals should describe a credible pathway from their project results and outcomes towards the expected impact of this Destination;Enable the acceleration of the market uptake of groundbreaking innovations in the decarbonisation of the chemical industries as well as alternatives to substances of concern. Scope:This open topic aims to speed up the adoption of new, groundbreaking innovations (starting TRL 4 ) as part of the Chemical Industry Action Plan, in the areas of decarbonisation of energy intensive industries, circular economy or breakthrough production technologies; as well as development of alternatives (new chemical substances, advanced materials or technologies) to substances of concern. Application of the SSbD Framework should be considered as appropriate.

Expected Outcome:Increased economically viable and functionally equivalent renewable material and sustainable chemical solutions used in large scale textile applications, including apparel, home and technical textiles;A realistic pathway for an absolute reduction of the use of virgin fossil-based materials and chemicals used to produce textile products for the EU market by 2035, contributing to enhance the preservation of human health, biodiversity and ecosystems, whether aquatic or terrestrial ecosystem preservation and emission reduction;Uptake of business models and system approaches that allow for the scale up of sustainable textile material and chemical alternatives as competitive alternatives to conventional approaches. Scope:Innovative renewable textile fibres and sustainable chemical solutions today face almost insurmountable cost disadvantages compared to extremely cost-competit...

Expected Outcome:Enhanced valorisation of intellectual assets, including dormant patents, from universities and public research organisations to support the adoption of green and digital technologies by industry, SMEs and start-ups/spinoffs.Development of entrepreneurial skills and increased involvement of students, researchers, and innovators in the valorisation of research results.Uptake of effective models and tools to facilitate valorisation of unused IP and intellectual assets and access by startups, SMEs, and innovative companies to this untapped knowledge in public research organisations. Scope:Aligned with the European Union's policy priorities, this action will contribute to overcoming the innovation paradox by maximising the impact of public spending in R&I through improved knowledge valorisation practices, and facilitating the uptake of green and digital technologies by start-...

Expected Outcome:Increased recovery rates of valuable raw materials, particularly critical raw materials from low grade or complex ores and/or from mining waste;Increased economic performance in terms of higher material-, water-, energy- and cost-efficiency and flexibility in minerals processing and metallurgical processes; andImproved health, safety and environmental performance of the operations throughout the whole life cycle that is considered, including a reduction in waste, wastewater and generation of emissions of air pollutants and a better recovery of resources from generated waste, reducing the environmental footprint and contributing to biodiversity and ecosystems preservation. Scope:Actions should develop and validate / demonstrate pilot scale facility located in the EU integrating relevant processing and refining technologies for improved recovery of raw materials from low g...

Expected Outcome:Reducing dependencies of critical and strategic raw materials through partial or total substitution by safe and sustainable innovative advanced materials and/or via more efficient use of critical and strategic raw materials in production processes;Speeding up the innovation cycle within value chain(s) important for European industry;Enhancing competitiveness of the industries and operational costs, while making supply chains more secure;New or improved production processes, innovative advanced materials and products that are safer and more sustainable, supporting a clean and autonomous economy; andDemonstrating how the safe and sustainable by design (SSbD) chemicals and materials framework can guide innovation. Scope:The focus of this topic is on alternatives for the substitution or more efficient use of critical and strategic raw materials[1]. The design and development...