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Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:competitiveness, sustainability (where relevant including biodiversity restoration), and resilience of agriculture, forestry and rural areas is fostered, by providing impartial and tailored knowledge to advisors and end-users[1];advisors are better integrated into the Agricultural Knowledge and Innovation Systems (AKIS) with up-to-date, practice-oriented knowledge that enables them to provide farmers with high quality and impartial advice;research findings, innovative solutions, practical knowledge and best practices, are well known, widely shared and used in practice by end-users. Scope:There is a growing need to disseminate practical knowledge on challenges and opportunities for agriculture, forestry and rural areas stemming from both scientific-research and practical experience, and t...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:advisors are better equipped with up-to-date knowledge, skills and tools to support young generation in entering into and successfully running the farming business, while taking into account the consequences of climate change and biodiversity loss; an attractive, high-quality training offer and advice suited to the evolving skills demands of the new generation attract young, talented farm entrepreneurs and lead to a new wave of innovative agricultural businesses. Scope:Generational renewal is a prerequisite for European farming systems to remain resilient and competitive in the medium and long term. The actions funded under this topic is relevant to the EU policies related to the EU Vision for Agriculture and Food and the objective to shape an attractive farming and agri-food sector for...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:the capacity of farmers and other agri-food supply chain operators to prevent, prepare for, cope with and manage diverse risks and crises, considering potential compound and amplifier effects under climate change, and their impacts, is improved in an integrated way;policymakers benefit from evidence and better understanding on how to enable more effective strategies for prevention and management of diverse risks and crises affecting farmers, considering compound and amplifier effects of climate change and biodiversity loss;knowledge and solutions to improve the resilience of farming systems are available and accessible to farmers and other agri-food supply chain operators through active and effective dissemination and engagement activities. Scope:Farmers are exposed to numerous and incre...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:strengthened coordination between European and national research and innovation programmes and agendas in the areas of the Standing Committee on Agricultural Research (SCAR) Working Groups (WGs), resulting in a reinforced European Research Area (ERA);improved impact and visibility of the SCAR WGs through organisation, facilitation and reporting of SCAR WGs activities on the various themes of main relevance for European R&I activities and relevant policy initiatives, leading to enhanced R&I cooperation and information exchange between Member States and Associated Countries and synergies at national and EU level;SCAR WGs are supported in delivering their objectives as outlined in their mandates by various measures including through capacity building and support for SCAR WG cross-collaborat...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:farmers and other decision makers of the agri-food supply chains have a better understanding of the determinants of competitiveness, and the interactions with the sustainability dimensions (economic, social, environmental, including biodiversity protection and climate change mitigation and adaptation);farmers, policy makers and other decision makers of the agri-food supply chains benefit from improved collection and access to data and analytical tools, enabling better-informed decisions conciliating competitiveness, sustainability and resilience objectives;policy makers are better equipped to develop evidence-based policies. Scope:The agri-food sector is an important pillar to EU competitiveness. It is composed of diversified businesses representing around 15% of total EU employment and...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:innovative AI-based solutions provide advisors, farmers and foresters with comprehensive, tailored and impartial advice to farmers and foresters to support them in their decisions as well as on the selection of innovative solutions, boosting the competitiveness, sustainability and resilience of the EU agriculture and forestry sectors;capacity and skills of advisors, farmers, and foresters related to the effective use of AI solutions are improved;use of existing and new data relevant for the decision-making for the optimized management of operations and the selection of innovative solutions on farms and in forests is increased. Scope:Digital technologies hold the potential to revolutionise farming and forestry, offering new opportunities to meet the rising demand for food, as well as biom...

This Notice of Funding Opportunity (NOFO) invites R25 applications to support the development and implementation of summer research education programs for high school students, undergraduates, or science teachers from all backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences. It is essential to expand and broaden the skilled Alzheimer's Disease (AD) and Alzheimers Disease Related Dementias (ADRD) research workforce and provide exposure to AD/ADRD research to individuals early in their careers. The proposed research education programs will support intensive summer research experiences in the AD/ADRD field with the goal of exposing participants to AD/ADRD research and encourage further study or participation in biomedical and behavioral research. This NOFO does not allow participants to lead an independent clinical trial, but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

This Notice of Funding Opportunity Announcement (NOFO) invites R25 applications to support the development and implementation of research education programs for recent baccalaureates from all backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences. It is essential to expand and broaden the skilled Alzheimers Disease (AD) and Alzheimers Disease and Related Dementias (ADRD) research workforce and provide exposure to AD/ADRD research to individuals early in their careers. The proposed research education programs will support intensive research experiences in the AD/ADRD field with the goal of preparing recent baccalaureates to transition into strong, research-focused advanced degree programs or competitive private sector research careers in AD-related disciplines.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs.

The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-end, specialized, commercially available instruments or integrated systems. The minimum award is $750,001. There is no maximum price limit for the instrument; however, the maximum award is $2,000,000. Instruments supported include, but are not limited to, nuclear magnetic resonance spectrometers, X-ray diffractometers, mass spectrometers, high throughput robotic screening systems, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.

The Basic Instrumentation Grant (BIG) Program encourages applications from groups of NIH-supported investigators to purchase a single piece of new, costly, specialized, commercially available instrument or an integrated instrumentation system. The BIG Program is limited to institutions that have not received S10 instrumentation funding of $500,001 or greater in any of the preceding 3 Federal fiscal years (FY). Use the following to determine applicable funding periods: for submission in CY 2026, consider S10 funding in FYs 2023-2025; for submission in CY 2027, consider S10 funding in FYs 2024-2026; for submission in CY 2028, consider S10 funding in FYs 2025-2027. The minimum award is $25,000. There is no maximum price limit for the instrument; however, the maximum award is $350,000. Instruments supported include, but are not limited to, basic cell sorters, confocal microscopes, ultramicrotomes, gel imagers, or computer systems.

The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-priced, specialized, commercially available instruments or integrated instrumentation system. The minimum award is $50,000. There is no maximum price limit for the instrument; however, the maximum award is $750,000. Instruments supported include, but are not limited to: light microscopes, biomedical imagers, mass spectrometers, nuclear magnetic resonance spectrometers, flow cytometers, DNA and protein sequencers, biosensors, and X-ray diffractometers.

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions using a milestone-driven, biphasic award mechanism, R61/R33 Phased Innovation Award. Specifically, this NOFO solicits applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. The first phase, funded by the R61, will providing for up to 2 years to identify unique host biological patterns (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with heterogeneity of probiotic clinical effects using observational or secondary data analysis studies. The second phase, funded under the R33, will support studies to assess the ability of the unique patterns determined in the R61 phase to detect the improvement of probiotic responsiveness in rigorously designed mechanistic studies in relevant animal models or in human subjects. The combined R61/R33 should not exceed 5 years. Transition from the R61 to the R33 phase of the award will be administratively reviewed and will be determined based on successful completion of Transition Milestones that need to be clearly specified in the R61 phase application. Support for...

Expected Outcome:Project results are expected to contribute to the following outcomes:For researchersEnhanced opportunities to interact with citizens and local, regional and national authorities;Improved communication skills and competences to interact with a non-research audience, notably with pupils and students. For organisationsIncreased reputation and visibility of participating organisations in terms of hosting excellent research projects towards the general public and possible future students;Researchers’ work made more tangible, concrete, accessible, and thus opening research and science to all;Improved outreach to all audiences across Europe, and notably those who do not have an easy access to science and research activities;Better communication of R&I results and activities to society, increased and strengthened opportunities for citizens’ engagement. Scope:Proposals should cov...

This Notice of Funding Opportunity (NOFO) encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards. The resources should already be established or may be formed through consolidation of existing local or regional facilities. The intent is to provide resource access to investigators without regard to the specific biomedical focus of their research, while not duplicating or replacing resources supported by sources such as other NIH Institutes and Centers (ICs) or host institutions. The resource is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through a robust web presence and outreach activities, and provide user training and support.

Expected Outcome:For all areas:More efficient access to the best research infrastructures available to researchers and innovators to conduct challenge-driven research, improve responsiveness to emerging challenges and foster innovation, irrespective of location, through a single-entry point access portal, integrated or interoperable catalogues of services and converging access conditions and selection procedures;Breakthrough and leading-edge research enabled by advanced research infrastructure services, including joint research activities, made available to a wider user community, including in emerging areas of research;A new generation of researchers trained to optimally exploit all the essential tools for their research with due attention to early-stage career researchers and researchers from widening countries and candidate countries;Cross-disciplinary fertilisations and a wider shari...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:More efficient access to the best research infrastructures available to researchers and innovators to conduct basic and applied research and foster innovation, irrespective of location. A single-entry point access portal, integrated or interoperable catalogues of services and converging access conditions and selection procedures;A step towards a longer-term sustainable access programme harmonised across different ESFRI domains;Breakthrough and leading-edge research enabled by advanced research infrastructure services, including from emerging facilities, made available to a wider user community, including in emerging areas of research;A new generation of researchers trained to optimally exploit all the essential tools for their research with due attention to early-stage career researchers an...

Expected Outcome:Projects are expected to contribute to several of the following expected outcomes:Increased performance, scientific capacity and excellence of the European landscape of research infrastructures enhancing problem-solving capacities of the ERA to address challenges in science, industry and society;Legal, financial and technical issues addressed, leading to long-term perspective for research infrastructure investments and the establishment of a new research infrastructure and ensuring commitment of Member States/Associated Countries to their long-term operation and use;Solid ground for the decision making on new research infrastructures (or major upgrades), is available to Member States/Associated Countries, their funding bodies and other relevant stakeholders (e.g. international organisations, third countries, foundations);Structuring effect on the ERA through a consistent...

Expected Outcome:Actionable and widely tested research-to-action pilot solutions in addressing complex cross-sectoral problems caused and/or exacerbated by climate change in key socio-environmental and socio-economic sectors.Innovative use of Artificial Intelligence (AI) by further development of the data lab infrastructure around Destination Earth in line with the AI continent Action Plan[1].Multi-country approach with real end user engagement to ensure solutions that are accessible, and effectively integrated into real policy, preparedness and response efforts. Scope:The focus is on large-scale pilots and demonstrators to enable researchers, expert and non-expert users, including decision-makers, to experiment with and through the existing Destination Earth system and harness it to widespread cross-societal use through new innovative methods, practices, tools and services. It will also...

Expected Outcome:Project results are expected to contribute to the following outcomes:Better overview of the identified opportunities and barriers of the EU’s current legal framework on intellectual property (patents, copyright, licenses etc.) for researchers to valorise knowledge resources provided and/or processed in the EOSC Federation.Organisations contributing resources to the EOSC Federation have improved capacity, stronger incentives and better legal and technical conditions to valorise these knowledge resources and engage in open innovation practices and industry-academia collaboration.Organisations contributing to the EOSC Federation have clearer frameworks and incentives to offer their resources to innovators, deep-tech startups and startups emerging from academia.Organisations contributing to the EOSC Federation have established channels in EOSC to promote knowledge valorisati...

Expected Outcome:Project results are expected to contribute to the following outcomes:The EOSC Federation provides to EOSC users with state-of-the-art digital services addressing their needs to store, process and share data, run software, models and workflows, and collaborate with their peers.Research and digital infrastructures and other organisations providing scientific services are equipped with appropriate structures and technical, legal and coordination mechanisms to onboard, manage and sustainably operate digital tools and services in the EOSC Federation.Investments across Europe in the provision of FAIR scientific data and services within EOSC are more aligned and coordinated, achieving economies of scale and more efficient use of digital resources. Scope:In order to carry out typical research workflows, researchers need to use a broad range of digital services such as data stora...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Better connection of research infrastructures across the European Research Area reinforcing and spreading excellence throughout the European Research Area;mitigating scattered national and regional research infrastructures and pockets of scientific excellence, and increasing the circulation of knowledge;wider, simplified, and more efficient access to the best research infrastructures available to researchers to conduct curiosity-driven excellent research, irrespective of location;breakthrough and leading-edge research enabled by advanced research infrastructure services made available to a wider user community;enhanced integration of a wider user community in the European research infrastructure ecosystem; enhanced capacities of a wider user community to address research challenges and EU p...

Expected Outcome:The objective of this topic is strengthening the European research infrastructure landscape as a pillar of Europe’s innovation-based competitiveness and reinforcing its role in the overarching policy priority of making Europe the top region for deep-tech startups and scaleups. Project results are expected to contribute to several of the following expected outcomes:Enhanced scientific and technological competitiveness of European research infrastructures, through the co-development of innovative technologies and solutions that improve the performance of RI services, addressing common needs across different types of research infrastructures, where applicable.Increased cooperation and coordination between European research infrastructures, and between them and other public and private research performing organisations, in order to create a coherent and supportive ecosystem...

Expected Outcome:Project results are expected to contribute to several of the following expected outcomes:better structured, integrated and strengthened European research infrastructure landscape;solid concepts and/or comprehensive plans for the integrated research infrastructures, to support decision making at national and European level, leading to increased sustainability, operational and financial efficiency;increased synergies between research infrastructures;increased capacity to address EU policy priorities and/or support EU industry;reinforced global competitiveness and attractiveness of the European Research Area. Scope:This topic targets the consolidation and improved functioning of the EU RI landscape through the support to the development of complementarities, synergies and/or integration between a set (two or more) of ESFRI Landmarks and/or other European Research Infrastruc...