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Expected Outcome:Activities under this topic will help progress towards the objectives and targets of the Mission Soil and should contribute to meeting the relevant targets of the EU Soil Strategy for 2030 and the Zero Pollution Action Plan, as well as to the Sustainable Development Goals[1].Project results are expected to contribute to all the following expected outcomes:improved citizen awareness on the connection between soil pollution and human health and how to manage, adapt to, and mitigate risks;increased public access to FAIR[2] data and knowledge on soil pollution and the emergence of human diseases and other health outcomes;policymakers enforce the implementation of long-term, sustainable solutions that enhance soil health, restore the environment, and protect public health. Scope:Across the European Union, an estimated 2.8 million land sites are potentially contaminated. Expos...

Expected Outcome:Proposals are expected to contribute to all the following expected outcomes:Strengthen the competitiveness, sustainability (including biodiversity) and resilience of an innovative clean tech solution by clearly demonstrating the capability to, significantly: increase its circular material use rate, based on a sound and realistic baseline; reduce the levelized cost of energy (LCOE) delivered to end-users - including, where relevant, production, distribution, and storage costs, based on a sound and realistic baseline and considering different geographic scenarios; and contribute to Europe’s industrial leadership and competitiveness, in line with the objectives of Net-Zero Industry Act (NZIA)[1] for the EU manufacturing capacity of net-zero technologies[2],[3]. Bring this innovative clean tech solution to full technological maturity and close to market-readiness with a view...

Expected Outcome:Proposals are expected to contribute to one or more of the following:Enhanced resilience against distributed cyber threats and adversarial attacks targeting interconnected systems, while preserving data privacy in highly dynamic and heterogeneous environments;Security solutions tailored to distributed computing systems including for example IoT and edge computing environments, integrating privacy-preserving mechanisms;Improved interoperability of security measures and cross-layer security, including the compatibility of privacy-enhancing technologies across different layers of the computing continuum and data spaces, and across providers in the multi-provider edge cloud continuum. Scope:This topic aims to advance security across the entire computing continuum, spanning IoT devices, edge computing, cloud infrastructures, AI computing environments, and data spaces. Proposa...

Expected Outcome:Proposals are expected to contribute to all the following expected outcomes:Accelerate the use of innovative technologies to decarbonise industrial processes and bring to the market more cost-effective clean products to strengthen the competitiveness, sustainability (including biodiversity), and resilience of EU industries;Create new innovative first-of-a-kind operational demonstrators and/or optimise newly installed industrial decarbonisation solutions in Europe; andDemonstrate the market readiness of the envisaged future clean products and their innovative processes via a credible business plan and an exploitation strategy for industrialisation, including market-tested use cases. Scope:The Clean Industrial Deal aims to secure the EU as an attractive location for manufacturing, including for energy-intensive industries, and to promote clean tech and new circular busines...

Expected Outcome:Proposals are expected to contribute to one or more of the following:AI-driven solutions for real-time cyber threat detection;Advanced adaptive AI systems that evolve with dynamic cybersecurity challenges;Contribute to drastically reduce reaction time for the recovery of systems. Scope:Artificial Intelligence is increasingly utilised in cybersecurity for threat detection, incident response, and adaptive defence mechanisms. However, AI-driven systems themselves are susceptible to adversarial manipulation and bias. This topic aims to advance AI-based cybersecurity applications while ensuring that AI-driven solutions remain resilient, transparent, and compliant with regulatory frameworks such as the AI Act. In this context, the topic explores the role of all types of AI, including generative AI, in cybersecurity applications, including automated threat detection, adaptive c...

Expected Outcome:Proposals are expected to contribute to one or more of the following:New primitives beyond Quantum Key Distribution (QKD) for future hybrid classical-quantum and quantum networks either as quantum equivalents of classical primitives or as new primitives for new practical applications, also in the relativistic setting when relevant, or as new primitives and protocols with modular, realistic integration of solutions from different cryptographic approaches, with focus on beyond-QKD applications and with gradual release on trust in hardware;Analysis of the applicability and strength of the results compared to their best classical-only counterpart, critical analysis of the formal assumptions and of performance, security proofs;Investigation of fundamental aspects of quantum information processing tasks, their eventual limits; and/or the connection between quantum computing an...

Expected Outcome:Proposals are expected to contribute one or more of the following:Practical robust implementations of PQC schemes that can withstand implementation attacks including side-channel attacks, fault attacks and combined attacks, and design of automated tools for evaluating the security of PQC implementations. Comprehensive guidelines for implementing countermeasures against a wide range of attacks;Advances in understanding the quantum hardness of mathematical problem classes; new quantum algorithms and improvements in quantum programming and implementation; security validation methods; design of post-quantum schemes with improved security against quantum and AI-based attacks;Post-quantum schemes and protocols to support privacy-friendly applications and services, ncluding the secure and private use of electronic identities. Design of new digital signatures, key encapsulation...

Expected Outcome:Projects are expected to contribute to all of the following outcomes:Demonstrated system-level long-duration energy storage (LDES) solutions, explicitly aimed at enhancing grid stability, resilience, and flexibility in Europe. Substantial reduction of Europe's dependence on critical raw materials through the use of abundant, low-cost, and sustainable materials.Contribute to strategic insights for a coherent EU-wide stationary storage deployment strategy, enhancing European energy autonomy and sustainability.Sufficient and reproducible operational data and insights to serve as reliable input towards detailed technoeconomic analyses. Scope:Proposals should focus on system-level demonstrations of innovative long-duration (> 8 hours) battery storage concepts that can effectively support utility-scale energy systems or industrial consumers in achieving energy security and ope...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Improved resource efficiency compared to current practices;Improved accuracy (designed vs. as-built) of on-site renovation and construction works, compared to current best practices;Significant reduction in time spent by building professionals on site;Reduced GHG emissions at the construction site. Scope:The rate of deep renovation of buildings can be accelerated by modernising the construction sector and embracing the latest developments in robotics and automated systems. There is need for further development of techniques using innovative on-site robotic and other automated systems that make renovation and construction works more sustainable, less disruptive, faster as well as more accurate, cost effective and resource efficient, while delivering, at least, the same building elements’...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Demonstration of measurable reductions in material flows, life cycle energy use and GHG emissions in building renovations that integrate circularity strategies to contribute to achieving net-zero whole life carbon buildings;More robust approach to current modelling frameworks to comprehensively reflect the complexity of circularity strategies in life cycle assessments at building scale. Scope:European buildings are increasingly adopting circularity strategies in renovations to reduce life cycle environmental impacts and improve resource efficiency in response to the requirements based on current frameworks, such as Level(s) and WLC models used by Member States based and EN 15978 standard. The complexity of these circularity strategies, such as material reuse and recycling, and addressing...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Improved open access to performance data, sharing of best-practices and useful knowledge and information for owners and operators of IT infrastructure, as well as the IT and building sectors;New designs of IT rooms in buildings or small edge data centres valorise waste heat through thermal management techniques, processes and tools. Scope:The growing energy needs of the ICT sector must be met while aligning with climate neutrality and sustainability goals. Small IT rooms or small data centres are an essential part of the twin green and digital transition. It is important to address the energy and resources consumption over the full ICT value chain. Solutions already exist, such as re-using waste heat from data centres, or moving towards circular models (longer lifetimes, reparability, re...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Based on the results of the project, at least one industrial sector with a significant heating demand in the EU and Associated Countries develops pathways and business models to measurably increase the industrial excess/waste heat recovery and conversion to power.Measurable improvement of industrial excess/waste heat recovery and conversion to power, possibly combined with energy storage, in terms of energy efficiency, flexibility of electricity production, climate and environment protection, reliability and safety, physical and cyber security, and profitability. Scope:Better use of process excess/waste heat represents a significant source of energy savings for industries. The conversion of excess heat back to electricity, would improve energy efficiency, mitigate the increase of electri...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:increased circularity and reduced emissions of greenhouse gases and air pollutants in the economic sectors, services and product value chains at local and/or regional scale. This also includes an efficient valorisation of local resources, with positive effects on air and water quality as well as on biodiversity;widespread deployment and easier replication, scalability and visibility of circular systemic solutions for a multiplication of their economic, social and environmental benefits;enhanced collaboration and knowledge transfer between public authorities (cities and regions), companies, research and citizens in addressing environmental challenges, such as climate-change, resource depletion and biodiversity loss. Scope:This topic supports the implementation of the European Commission’s...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:urban manufacturers significantly increase their resource efficiency through increased circular material use or reduced overall material use per output;urban manufacturers contribute significantly to EU climate, zero pollution, circularity and biodiversity goals by engaging in clean, sustainable and circular business practices;improved knowledge sharing and proliferation of digital tools and methods that facilitate the adoption of circular business practices and enable large-scale diffusion. Scope:The Clean Industrial Deal confirms Europe’s dedication to its decarbonisation goals by offering clear business incentives. It will help create lead markets to boost supply and demand in clean tech and energy-intensive industries (such as chemicals, cement, steel and metals), enabling the decarb...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Measurable improvements in the competitiveness and increased environmental sustainability of the EU’s fisheries and/or aquaculture sectors by integrating circular economy principles;Minimized and better managed waste products derived from fisheries and/or aquaculture sectors as well as improved reutilization and reduction of by-products;Reduced existing barriers preventing the implementation and development of circular principles in seafood chains, such as the cost of advanced processing technologies, regulatory hurdles, lack of collaboration across the different seafood supply chain actors or limited market demand and acceptance;Measurable socio-economic benefits for local stakeholders and communities involved in the seafood processing chain. Scope:Proposals under this topic are expecte...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Increased area and improved condition of marine and coastal vegetated habitats within EU waters through effective on-site conservation, restoration and management of activities to help deliver on the objectives of the Nature Restoration Regulation;Maintained and enhanced capacity of blue carbon ecosystems to naturally store carbon, supporting EU climate mitigation goals;Enhanced capacity of marine vegetated habitats/blue carbon ecosystems to support biodiversity and fisheries;Established novel financing and incentive mechanisms that support conservation, restoration and management of blue forest ecosystems projects;Raised public awareness and improved community participation in blue forest ecosystems protection, restoration and management activities, ensuring long-term involvement. Scope...

Expected Outcome:In support to the implementation of the EU Adaptation Strategy, the EU Mission on Adaptation to Climate Change and the EU Preparedness Union Strategy and contributing to the upcoming European Climate Action Plan, project results are expected to improve adaptative capacities of European internal border regional and local authorities, allowing them to jointly address with their neighbours the pressing climate risks.Projects results should contribute to all of the following outcomes:Climate resilience solutions for cross-border risks have been developed and demonstrated. This includes social, governance or nature-based solutions.Regional and local authorities from each side of country borders are better prepared to withstand jointly the impacts of climate change, including systemic risks and cascading effects.National, regional and local authorities are taking on shared res...

Expected Outcome:AI has the potential to support or facilitate virtually every aspect of regions’ climate adaptation efforts. From risk assessment to climate forecasting, from infrastructure planning to resource management, and more. Contributing to the objectives of the AI Continent Action Plan and the EU Mission on Adaptation to Climate Change, projects are expected to contribute one of the following:AI is used to improve actionable climate adaptation knowledge for European regions and local authorities by integrating climate data into decision-making processes.Specific sectors in the selected regions become more resilient to climate change thanks to the use of AI to improve their processes or technologies, while simultaneously advancing their digital transformation. Scope:RationaleOver the past few years, a rapid and disruptive acceleration of progress in Artificial Intelligence has o...

Expected Outcome:This topic aims at directly engaging with and supporting riparian and coastal areas, waterfront cities and islands and their communities in demonstrating and accelerating the transitions needed for achieving one or several objectives of the Mission “Restore our Ocean and Waters”. The participation of relevant public bodies managing those areas and their communities as partners of the consortium is strongly encouraged.Project results are expected to contribute to all the following outcomes:Member States and Associated Countries are provided with cost-effective and innovative solutions to increasing riparian and coastal areas’ resilience to climate change, especially in waterfront cities and islands, contributing to reach the targets of the EU climate adaptation and water resilience strategies for 2030, but also supporting achievements of the EU biodiversity strategy for 2...

Expected Outcome:Activities under this topic will directly progress towards the goal of the Mission Soil to set up 100 living labs and lighthouses to lead the transition to healthy soils by 2030. Activities will also contribute to the goal of the Cancer Mission, i.e.: ‘to improve the lives of more than 3 million people by 2030, through prevention, cure and for those affected by cancer including their families, to live longer and better’. Activities should also contribute to meeting the European Green Deal ambitions and targets and more specifically those of the EU Biodiversity Strategy for 2030, the EU Soil Strategy for 2030, the proposal for a Soil Monitoring and Resilience Directive, the Zero Pollution Action Plan, the Europe's Beating Cancer Plan, the One Health approach, the European Health Data Space, the Chemicals Strategy for Sustainability, the European Chemicals Industry Action...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards, and contribute to all of the following expected outcomes:Patients afflicted by lung, bowel, breast or prostate cancer[1], will benefit from the outcomes of evidence-based, tailored, innovative, affordable and accessible diagnosis- and treatment-centred clinical research programmes by comprehensive cancer infrastructures[2].Researchers, physicians, patient representatives, civil society, charities, foundations, insurance companies, SMEs and innovators[3] will seize opportunities to respectively co-create, support, upscale or commercialise outcomes of evidence-based, tailored, affordable and accessible clinical research programmes for the diagnosis and treatment of patients afflicted by lung, bowel, breast or prostate cancer.National and regional healthcare providers, healthcar...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards, and contribute to all of the following expected outcomes:Patients with rare or very rare cancers or cancer subtypes have access to tailored, promising biomarker-guided medicines or multi-modal treatment interventions via participation in subsequent clinical trials or national or regional compassionate use programmes by health authorities;Researchers, physicians, innovators[1], startup, spin-off and spin-out companies, SMEs, charities or foundations and other professionals from different disciplines and sectors have access to innovative technology, medical devices or promising biomarker-guided medicines for further validation or commercialisation;National healthcare providers, policymakers and authorities in European regions, EU Member States and Associated Countries have earl...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:Researchers and health professionals gain a deeper understanding of the functional effects of tumour heterogeneity during cancer initiation and progression, supporting the identification of more precise and novel therapeutic targets. Researchers, health professionals and innovators benefit from improved knowledge and tools to support the discovery and development of next generation genomically-informed cancer treatments.Researchers, innovators, and professionals across disciplines and sectors contribute to the UNCAN.eu research data platform by ensuring data interoperability, and enabling sustainable access to newly developed digital tools and models for the analysis and management of multimodal clinical data. Scope:The...

Expected Outcome:This action supports the follow-up to the July 2023 Communication on EU Missions assessment[1]. The successful proposal under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes:Together, a network of registered cancer charities and funding agencies support transnational research and innovation projects on quality of life of children (age range 0-14, age at time of first diagnosis), adolescents (age range 15-19, age at time of first diagnosis) and young adults (age range 20-39, age at time of first diagnosis), cancer patients and survivors using their own financial resources.Projects supported by the network of charities and funding agencies will boost quality of life and long-term outcomes for young cancer patients and survivors, including improved physical, emotional, and social well-b...

Expected Outcome:Proposals under this topic should aim to deliver results that are directed and tailored towards, and contribute to all of the following expected outcomes:People at risk of cancer, cancer patients and their caregivers/families benefit from access to more effective and cost-effective, national or regional, cancer control programmes across EU Member States and Associated Countries.Researchers, physicians, innovators[1], SMEs and other professionals from different disciplines and sectors have access to national, regional or local data on healthcare spending (such as expenditures, resource allocations, organisation and type of healthcare interventions, and for which cancer indications, infrastructure, medical prescriptions, drug pricing, drug sales, reimbursement data from health insurers, population-based cancer registries or other cancer-centred registry data, longitudinal...