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Summary: The fiscal year 2026 (FY26) Rare Cancers Research Program (RCRP) Resource and Community Development Award (RCDA) supports the development of research resources and clinical or preclinical datasets that will advance the field of rare cancers research and ultimately improve outcomes for individuals with rare cancers. Research supporting this funding opportunity should fill one of the following major gaps:Lack of research and clinical resources, including patient tissues, cell and tumor models.Lack of communication and dissemination strategies within scientific and patient communities for sharing rare cancers research and clinical findings.Lack of infrastructure for sharing data and other resources.Lack of therapeutics and mechanistic research to inform treatment development.Distinctive Features:Documentation of plans for engagement and partnerships with Patient Advocates throughout the life cycle of the research study from development of the research question through execution of the study.Community building and enhancement are key components.A description of the dissemination and sustainability of the platform for scientific and/or clinical and patient community is required.Preliminary data are not required but may be included to address feasibility.

Summary: The fiscal year 2026 (FY26) Orthopaedic Research Program (ORP) Clinical Research Award (CRA) seeks clinical research that evaluates orthopaedic-specific factors and interventions. The ORP intends for research supported by this mechanism to generate clinically useful evidence with potential to optimize patient outcomes and inform clinical care or policy. Applications must address how the proposed research will impact patient care and reduce the burden of orthopaedic injury and sequela. The ORP expects that research findings benefit Service Members, their families, Veterans and the general public. To meet the intent of the award mechanism, applications must specifically address at least one of the FY26 ORP CRA Focus Areas.Distinctive Features: ·        The CRA offers two research levels.Research Level 1 (RL1) supports clinical research in the following FY26 ORP focus areas:·        Ligamentous Trauma·        Osseointegration Outcomes·        Return-to-Duty Strategies·        Military Women’s HealthResearch Level 2 (RL2) supports clinical trials in the following FY26 ORP focus areas:·        Ligamentous Trauma·        Limb Stabilization and Protection·        Return-to-Duty Strategies

Summary: The fiscal year 2026 (FY26) Rare Cancers Research Program (RCRP) Idea Development Award (IDA) promotes ideas that are ready for further development and have the potential to yield high-impact findings and new avenues of investigation.Distinctive Features:The RCRP encourages applicants to include an exploratory aim or sub-aim to support any necessary discovery-driven research.Preliminary data with disease-specific rationale are required. However, these data do not necessarily need to originate from studies of the proposed rare cancer type(s)/subtype(s) under study.Research should have high potential impact on rare cancers and the patient community.

Summary: The fiscal year 2026 (FY26) Combat Readiness – Medical Research Program (CRRP) Translational Research Award (TRA) supports hypothesis-driven innovative, high-impact translational research that will accelerate the movement of promising ideas and/or technologies in trauma care into solutions to maximize casualty survivability, improve patient care closer to the point of injury and/or trauma care guidelines. Preliminary data are required. Research using well-validated animal models is allowed.Distinctive Features:• **NEW for FY26** An investigator may be named as the Principal Investigator (PI) on only one FY26 CRRP TRA application.• Research supported by the FY26 CRRP TRA must represent a mature, translational research effort with a minimum biomedical technology readiness level (TRL) of 4 or knowledge readiness level (KRL) of 4.

The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsychiatric symptoms in individuals across the spectrum from pre-symptomatic to more severe stages of disease. This NOFO uses the UG3/UH3 phased award mechanism and proposals must include prespecified, go/no-go safety and tolerability milestones that gate the advance from phase 1 to latter stages of clinical development.

This NOFO encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions; biomarker or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery; and ancillary studies designed to add scientific aims to active studies being conducted within StrokeNet. Successful applicants will collaborate and conduct the study within the NIH StrokeNet. Following peer review, NINDS will prioritize studies among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement the proposed study efficiently and the National Data Management Center (NDMC) will provide statistical and data management support. The NIH StrokeNet Regional Coordinating Centers (RCCs) and their affiliated clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol.

Summary: The fiscal year 2026 (FY26) Toxic Exposures Research Program (TERP) Clinical Trial Award (CTA) mechanism supports the advancement, execution, and analysis of clinical trials with the potential to have a significant impact on the prevention, treatment, or management of symptoms, diseases or conditions associated with or resulting from military-related toxic exposures. Proposed projects may range from small proof-of-concept clinical trials (e.g., pilot, first-in-human, phase 0) designed to demonstrate the feasibility or inform the design of more advanced trials, through large-scale trials (including pragmatic clinical trials) to determine efficacy in relevant patient populations.  Distinctive Features: To encourage applications that include meaningful and productive collaborations, the FY26 TERP CTA includes a Partnering Principal Investigator Option (PPIO). One Principal Investigator (PI) is identified as the initiating PI, and an additional PI may be identified as a Partnering PI. If recommended for funding, each PI will be named on separate awards. The intent is to support interdisciplinary partnerships, such as those between clinicians and research scientists, that will accelerate the movement of promising interventions/​knowledge products into clinical applications. Partnering should significantly advance the research beyond what would be possible through independent efforts. https://cdmrp.health.mil/pubs/press/2026/terppreann

Summary: The intent of the fiscal year 2026 (FY26) Toxic Exposures Research Program (TERP) Translational Research Award (TRA) is to support translational research that will accelerate the movement of promising ideas in military-related toxic exposure research into clinical applications, including health care products, interventions, technologies and/or clinical practice guidelines. Translational research may be defined as an integration of basic science and clinical observations. New Approach Methodologies may also be used. Applications should provide evidence for the reciprocal transfer of information between basic and clinical science, or vice versa, in developing and implementing the research plan.  Distinctive Features: To encourage applications that include meaningful and productive collaborations, the FY26 TERP TRA includes a Partnering Principal Investigator Option (PPIO). One Principal Investigator (PI) is identified as the initiating PI, and an additional PI may be identified as a Partnering PI. If recommended for funding, each PI will be named on separate awards. The intent is to support interdisciplinary partnerships, such as those between clinicians and research scientists, that will accelerate the movement of promising ideas into clinical applications. Partnering should significantly advance the research beyond what would be possible through individual efforts. https://cdmrp.health.mil/pubs/press/2026/terppreann

Summary: The fiscal year 2026 Toxic Exposures Research Program (TERP) Investigator-Initiated Research Award (IIRA) is intended to support studies that will make an important contribution toward research and/or patient care for diseases or conditions associated with military-related toxic exposures. Research projects may focus on any phase of research from basic laboratory research through translational research, including preclinical studies in animal models and human subjects, as well as correlative studies associated with an existing clinical trial. New Approach Methodologies may also be used. https://cdmrp.health.mil/pubs/press/2026/terppreann

The Louis Stokes Alliances for Minority Participation (LSAMP) program invests in the Nation's colleges and universities to aid student success to create a new generation of STEM discoverers for the national STEM enterprise. The program takes a comprehensive approach to the STEM Learning Ecosystem to impact STEM student development and retention. LSAMP is an alliance-based program, whereby a group of institutions of higher education (IHEs) work together to diversify the nation's science, technology, engineering, and mathematics (STEM) workforce by increasing the number of STEM baccalaureate and graduate degrees awarded to persons from LSAMP populations. LSAMP populations are defined as persons from groups underrepresented in the STEM enterprise: Blacks and African-Americans, Hispanic and Latino Americans, American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders. The LSAMP program provides funding to alliances that implement comprehensive, evidence-based, innovative, and sustained strategies that ultimately result in the graduation of well-prepared, highly competitive students from LSAMP populations who pursue graduate studies or careers in STEM, while also supporting knowledge generation, knowledge utilization, assessment of program impacts, dissemination activities and dissemination of scholarly research into the field. Projects supported by the LSAMP program include: --Alliance Development Grants (ADG) support the conceptualization and development of new B2B and new SPIO alliances. (New) --Bridge-to-the-Baccalaureate (B2B) alliances facilitate the successf...

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

The National Institutes of Health (NIH) hereby notifies NIH award recipients that funds may be available for revision applications to support the expansion of existing projects and/or programs within the awarding IC identified in the competitive revision Notice of Special Interest (NOSI). Applications for Revisions will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s), in accordance with NIH peer review policy and procedures, using the stated review criteria. Only applications submitted in response to a NOSI published by an NIH Institute or Center will be allowed to apply to this NOFO.

Notice of Temporary Pause: Information Innovation Office (I2O) Office-Wide Broad Agency Announcement (BAA) Action: Temporary Pause of Submissions Effective Date: 9 June 2026 at 5:00 PM ET Estimated Duration: Approximately 2-weeks, 22 June 2026 THIS BAA TEMPORARY PAUSE HAS BEEN EXTENDED. THE GOVERNMENT WILL NOT BE ACCEPTING ANY ABSTRACT SUBMISSIONS UNDER THIS BAA UNTIL FURTHER NOTICE. Effective 9 June 2026, the Information Innovation Office (I2O) Office-Wide BAA is temporarily paused. This pause is necessary to accommodate internal organizational changes, which includes an update to the I2O office name and a realignment of strategic priorities. Over the next few weeks, the Government will refine and update the BAA requirements to accurately reflect these new operational priorities. Submission Guidance During the Pause: Please be advised of the following instructions regarding proposal submissions during this period: • Abstract Submissions: Abstract submissions will NOT be accepted during this temporary pause. Abstracts received prior to this announcement remain under review. • Encouraged Submissions: Proposers who have received explicit, written encouragement from the Government to submit a full proposal may continue to submit during this pause. A future amendment will be published on SAM.gov to announce the resumption of this BAA.

Supports mathematical research in areas where computation plays a central and essential role, emphasizing analysis, development, and implementation of theoretically justified and efficient algorithms. The combination of these elements resulting in innovative computational methods is a hallmark of the program. Proposals ranging from single investigator to interdisciplinary team projects that not only create and analyze new computational mathematics techniques but also implement them to model, study, and solve important application problems are strongly encouraged, as is providing opportunities for rigorous mathematical training of junior computational mathematicians through research involvement. Conferences Proposals to the Computational Mathematics Program for conferences or workshops must be submitted through the program solicitation "Conferences and Workshops in the Mathematical Sciences" (link below). Principal Investigators should carefully read the solicitation to obtain important information regarding the substance of proposals for conferences, workshops, and similar activities. Unless an exception from the program is granted, to facilitate timely notification of the availability of support, the following requirements are in effect: Proposals for conferences, workshops, etc., to be held in the US must be submitted at least 6 months in advance of the conference start date; Proposals to support group travel to meetings outside the US must be submitted at least 8 months in advance of the meeting start date; Proposals for conferences, workshops, etc., whose budget request...

The Archaeology Program administers an annual Archaeometry competition with a target date of December 1. The goal is to fund projects in two main categories: To develop or refine anthropologically relevant archaeometric techniques. Examples include the development of methods to identify specific types of organic residues on ceramics or development of field applicable analytic techniques. To support laboratories which provide relevant services. This includes support of service laboratories which, for example, may provide dating trace element, isotopic and dendrochronological analyses. It also includes support for data archives, which function to strengthen basic archaeological infrastructure. Projects which apply standard archaeometic techniques with the goal to answer specific archaeological questions should be submitted to the Archaeology SeniorResearch Awards competition. Proposals are evaluated by both ad hoc reviewers and a panel composed of individuals who combine both archaeological and archaeometric expertise.

NIOSH is encouraging the submission of an application from qualified organizations for a National Center for Construction Safety and Health Research and Translation. Applicants are encouraged to propose multidisciplinary approaches and coordination for impactful applied and intervention research, hazard identification, and controls; develop partnerships for implementing prevention and intervention activities; and serve as a leader in research translation and research-to-practice for the protection of construction workers in the U.S. The Center will accomplish these goals by integrating and advancing research, research translation, best practices, policy and guidance, and capacity building. Center work should consider the NIOSH strategic plan and NORA construction research objectives. Center structure should take advantage of diverse scientific resources and focus on national worker safety and health issues. Centers should emphasize the creation and implementation of evidence-based solutions that address important construction industry safety and health problems. Collaborations with other academic institutions, nonprofit organizations, and other occupational safety and health-focused groups are expected. Applicants must concisely describe the occupational health burden of important safety and health issues in the construction industry and discuss how focused research and outreach activities will help alleviate the burden and reduce numbers. Applicants should also clearly articulate the anticipated impacts of the Center’s proposed work, both during the project period and beyo...

This NOFO seeks to advance research and training in high-priority areas of child health by stimulating the use of Environmental Influences on Child Health Outcomes (ECHO) Cohort data by postdoctoral fellows from relevant scientific disciplines. This RFA will provide opportunities for fellows to study child health outcomes through the analysis of ECHO's large longitudinal data sets within the NICHD Data and Specimen Hub (DASH) repository. ECHO's DASH dataset integrates de-identified longitudinal data from more than 71,000 participants across the U.S. Prenatal and child exposure data include physical, chemical, social, behavioral, and biological factors. ECHO's five primary pediatric outcome areas are pre-, peri-, and postnatal outcomes, upper and lower airway, obesity, neurodevelopment, and positive health.

This is a reissue of the Emerging Global Leader Program (K43) to align with the clinical trials policy.

This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion FOA PAR-.The purpose of the Fogarty Emerging Global Leader Award is to provide research support and protected time (three to five years) to an early career research scientist from a low- or middle-income country (LMIC) who holds a junior faculty position at an LMIC academic or research institution, as defined by the World Bank (http://data.worldbank.org/about/country-classifications/country-and-lending-groups , including low-income, lower-middle-income, and upper-middle-income countries). This intensive, mentored research career development experience is expected to lead to an independently funded research career at the LMIC institution or in another LMIC. This Funding Opportunity Announcement (FOA) invites applications from LMIC scientists from any health-related discipline who propose career development activities and a research project that is relevant to the health priorities of their country under the mentorship of LMIC and U.S. mentors.

CREST Center awards provide support to enhance the research capabilities of Minority-serving institutions (MSIs) through the establishment of centers that effectively integrate education and research. CREST Center awards promote the development of new knowledge, enhancements of the research productivity of individual faculty, and an expanded presence of students historically underrepresented in science, technology, engineering, and mathematics (STEM) disciplines. Successful CREST Center proposals will demonstrate a clear vision and integration of STEM research and education and will align with the mission of the Division of Equity for Excellence in STEM (EES) with respect to the development of a diverse STEM workforce. CREST Centers are also expected to provide leadership by meaningfully involving the efforts of those faculty, students, and postdoctoral researchers who are traditionally underrepresented in STEM at all levels. Centers are required to use evidence-based and innovative strategies to address salient broadening participation and workforce development issues, such as recruitment, retention, and mentorship of participants from underrepresented groups. Successful proposals are expected to achieve national research competitiveness, broaden participation in STEM, and generate sustained, non-CREST funding from federal, state, and/or private-sector sources. PhaseI and Phase II CREST Center Awards Preliminary proposals are required for Phase I and Phase II projects. Thus, an invitation from NSF must be received before submitting a full proposal. Both Phase I and Phase I...

The purpose of this notice of funding opportunity (NOFO) is to provide salary support for exceptional Research Software Engineers (RSEs) that contribute their skills to the development and dissemination of biomedical, behavioral or health related software, tools, and algorithms as well as to the training of prospective users of these tools.

See the application guidelines and instructions at arts.gov for more information.

Key programmatic objectives of the DoN HBCU/MI Program are achieved through the implementation and performance of three program goals:• enhancing the research and educational capabilities of HBCU/MIs in scientific and engineering disciplines critical to the defense mission of the U.S. Navy and U.S. Marine Corps,• encouraging cross-institutional, collaborative efforts that explore innovative solutions to naval science and technology (S&T) challenges, and• increasing the engagement of students in STEM fields important to the U.S. Navy and U.S. Marine Corps.This particular NOFO aims to enhance the research capacity and research infrastructure for HBCU/MIs. Competitive white papers and invited full proposals submitted to this NOFO must clearly and succinctly describe efforts that advance basic naval-relevant S&T, engage faculty and students in STEM discovery, and expand the research capacity of participant institutions.This announcement is only for research efforts that also promote student/faculty engagement, and expand the institution’s research capacity. This announcement is not intended for projects that focus on non-research STEM activities.The technical content of any proposed effort must contribute to the S&T mission and vision of the DoN.DeadlinesWhite Paper Inquiries and Questions-Email: don_hbcufoa@navy.mil09 September 2026 (Wednesday)White Papers must be received no later than18 September 2026 (Friday) at 5:00 PM Eastern TimeApplication Inquiries and Questions04 December 2026 (Friday)

The Boosting Innovative GEOINT-Science and Technology (BIG-ST) Broad Agency Announcement (BAA) invites proposers to submit innovative concepts to address hard GEOINT problems that align to one or more of the following technical domains: (1) Foundational GEOINT, (2) Advanced Phenomenologies, and (3) Analytic Technologies.BAA Process and Topic Call Publication:The BIG-ST BAA is a general announcement of NGA’s research interest, including criteria for selecting proposals and soliciting the participation of all offerors capable of satisfying the Government’s needs.The requests for abstracts and proposals are transmitted via Topic Calls that are published separately under the BIG-ST BAA General Solicitation at various times during the open period of the General Solicitation. Topic Calls will be published via updates to the BIG-ST BAA General Solicitation site on Sam.gov, Grants.gov, and/or the Classified IC-Acquisition Research Center (https://acq-ui.ace.proj.nro.ic.gov). If a Topic Call is Classified, interested parties must have an account to log into the Classified IC-ARC to see the notice, and all associated RFP documents. For additional support with account access, please contact the Classified ACE Help Desk at 855-4ACE.Interested parties should periodically check these websites for updates.No submissions shall be accepted to the General Solicitation; abstracts and proposals will only be reviewed in response to open Topic Calls. Please refer to the Topic Calls for Abstract and Proposal due dates. The BIG-ST BAA General Solicitation, HM047623BAA0001 Revision 3 (dated 04/25/2...

The Statistics Program supports research in statistical theory and methods, including research in statistical methods for applications to any domain of science and engineering. The theory forms the base for statistical science. The methods are used for stochastic modeling, and the collection, analysis and interpretation of data. The methods characterize uncertainty in the data and facilitate advancement in science and engineering. The Program encourages proposals ranging from single-investigator projects to interdisciplinary team projects.