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Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annotated specimens from NCI-supported or other clinical trials or observational cohorts/consortia for the purpose of clinical validation of the assay. Research projects proposed for this NOFO encourage multi-disciplinary interaction among scientific investigators, assay developers, clinicians, statisticians, and clinical laboratory staff. Clinical laboratory scientist(s) and statistical experts are highly encouraged to comprise integral parts of the application. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials, but rather the adaption and validation of assays to the point where they could be integrated into clinical trials as investigational assays/tools/devices.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications to support the validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This FOA will support investigator-initiated research for both analytical, and clinical validation of assays to be used in cancer treatment, control, or prevention trials supported by the NCI. This NOFO will also support the validation of pharmacodynamic markers and markers of toxicity. Applicants should have assays that work on human samples and whose importance is well justified for development into clinical assays. As chemotherapies and/or radiation therapies are increasingly combined with immunotherapies to enhance the durability of anti-cancer responses, assays for measuring multiple markers, including immune markers, can be developed and validated simultaneously. The UH2 phase of this NOFO supports analytical validation of assays for these molecular/cellular/imaging markers, which must be achieved within 2 years before assays may undergo clinical validation. The UH3 phase of this NOFO supports clinical validation of analytically validated assays for up to 3 years using well-annotated biospecimens from retrospective or prospective clinical trials or studies. This NOFO may be used to validate existing assays for use in other cancer clinical trials, observational studies, or population s...

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to accelerate the adoption and validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This NOFO will also support the validation of pharmacodynamic markers and markers of toxicity. Applicants to this NOFO must have an assay(s) whose performance has been analytically validated in specimens similar to those for the intended clinical use of the marker(s) and assay(s). As chemotherapies and/or radiation therapies are increasingly combined with immunotherapies to enhance the durability of anti-cancer responses, assays for measuring multiple markers, including immune markers, can be developed and validated simultaneously. The UH3 mechanism will support the clinical validation of established assays for up to 3 years using specimens from retrospective or prospective clinical trials or studies. This NOFO may be used to validate existing assays for use in other trials, observational studies, or population studies. Efforts to harmonize clinical laboratory tests, including investigation into the performance and reproducibility of assays across multiple clinical laboratories, are also appropriate for this funding opportunity. Projects proposed for this NOFO will require multi-disciplinary interaction and collaboration among scientific investigators, oncologists, statisticians, and cli...

Buyer: Vitens N.V. | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-14

Buyer: "De Haagse Scholen", stichting voor primair en speciaal openbaar onderwijs | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-14

Buyer: Comune di Caltanissetta - Direzione Urbanistica - Pianificazione Territoriale - SITR - Ambiente e Energia - Viabilità e Verde Pubblico | Notice type: cn-standard | Contract: services | Deadline: 2026-10-14

Buyer: Stadtwerk am See GmbH & Co.KG | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-14

The goal of this NOFO is to support doctoral candidates studying high-priority areas of child health for the completion of their doctoral dissertation research project. This NOFO seeks to advance research in child health by stimulating the use of Environmental Influences on Child Health (ECHO) Cohort data by doctoral students in relevant scientific areas. This RFA will provide students working on dissertations the opportunity to access the ECHO data within the NICHD Data and Specimen Hub (DASH) repository. ECHO"s DASH dataset integrates de-identified longitudinal data from more than 71,000 participants across the U.S. Prenatal and child exposure data include physical, chemical, social, behavioral, and biological factors. ECHO"s five primary pediatric outcome areas are pre-, peri-, and postnatal outcomes, upper and lower airway, obesity, neurodevelopment, and positive health. This award will facilitate the entry of promising new investigators into the field of early environmental exposures and child health research, enhancing the pool of highly talented researchers.

The purpose of this notice of funding opportunity (NOFO) is to foster research that will inform and support the optimization, delivery, sustainability, and effectiveness of empirically-supported practices for addressing the mental health needs of older adults with serious mental illness (SMI). To this end, NIMH seeks applications that propose work that is focused on practice-relevant questions and conducted within and/or across settings where older adults with SMI are likely to be identified as needing care (e.g., primary care and geriatric specialty clinics, assisted living and long-term care facilities, and community centers). Applications may propose research related to adapting, optimizing, and implementing efficacious treatment and services interventions and strategies to improve clinical and functional outcomes among aging populations; examining mutable factors that impact fair and impartial mental health care access, utilization, quality, and outcomes and may serve as targets for intervention development for older adults with SMI; and developing and testing innovative treatment and service interventions that address barriers to accessing quality mental health care. Projects may also focus on systems-level factors and approaches for addressing SMI and improving access to evidence-based interventions in later life, such as evaluation of health system policies and practices, interventions that facilitate care transitions and continuity across settings, and strategies to improve care linkages and coordination across systems.

Buyer: Flughafen Zürich AG - PMO | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-15

Buyer: CNRS - DR11 | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: Stadsmiljöförvaltningen | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-15

Buyer: Veiligheidsregio Utrecht | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: EPT BOUCLE NORD DE SEINE | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-15

Buyer: Hôpitaux Robert Schuman S.A. | Notice type: cn-standard | Procedure: comp-dial | Contract: supplies | Deadline: 2026-10-15

Buyer: Gemeente Zevenaar | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: Weihrauch Uhlendorff GmbH | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: Stadsmiljöförvaltningen | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-15

Buyer: Vereniging van Bos- en natuurterreineigenaren (VBNE) | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-15

Buyer: Gemeente Zoetermeer | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: Porin kaupungin hankintapalvelut | Notice type: pin-rtl | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: Centre Hospitalier de Cayenne "Andrée ROSEMON" | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-15

Buyer: GGD Zaanstreek-Waterland | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-15

Buyer: Rīgas valstspilsētas pašvaldības Pilsētas attīstības departaments | Notice type: cn-desg | Procedure: open | Contract: services | Deadline: 2026-10-15

Buyer: Avri | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-15