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The goal of this notice of funding opportunity (NOFO) is to address the opioid crisis and/or overdose events by supporting action-oriented research, accelerating the translation of addiction epidemiology, prevention, treatment services, and recovery research to practice. Proposed studies may target the individual, provider, organizational, community, or system level. This initiative prioritizes replicable and scalable approaches for accelerating the routine use of effective, evidence-based prevention, treatment and recovery interventions and services. The translation of research to practice and research relevant to chronic pain comorbid with substance use is also a priority. Research may deploy a variety of methods and approaches, including but not limited to identifying and characterizing malleable factors, developing and testing interventions and implementation strategies, deploying and testing collaborative data science approaches, and/or developing and testing approaches that integrate the collaboration of researchers and decision-makers at any levels (e.g., clinical-, health system-, public health- or policy-level).

Buyer: Local Government Operational Procurement Centre (LGOPC) | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-15

Buyer: Gemeente Hollands Kroon | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2029-02-15

Buyer: Univerzita Tomáše Bati ve Zlíně | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-16

Buyer: Univerzita Tomáše Bati ve Zlíně | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-16

Buyer: Region Norrbotten | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2029-02-18

Buyer: Efficiency East Midlands Ltd | Notice type: cn-standard | Procedure: restricted | Contract: works | Deadline: 2029-02-18

Buyer: Region Norrbotten | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2029-02-18

Buyer: Všeobecná fakultní nemocnice v Praze | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-19

Buyer: UAB „Ignitis grupės paslaugų centras“ | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-19

Buyer: UAB „Ignitis grupės paslaugų centras“ | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-19

Buyer: UAB „Ignitis grupės paslaugų centras“ | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-19

The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.

Buyer: NLSH ohf. | Notice type: cn-standard | Procedure: oth-mult | Contract: services | Deadline: 2029-02-21

Buyer: NLSH ohf. | Notice type: cn-standard | Procedure: oth-mult | Contract: services | Deadline: 2029-02-21

Buyer: Prosper | Notice type: cn-standard | Procedure: restricted | Contract: works | Deadline: 2029-02-23

Buyer: Office National des Forêts Direction territoriale Bourgogne Franche Comté Agence Etudes et travaux Bourgogne Franche Comté 14 rue Plançon - CS 51581 25010 BESANCON cedex 3. | Notice type: cn-standard | Procedure: oth-mult | Contract: supplies | Deadline: 2029-02-23

Buyer: Söderenergi AB | Notice type: cn-standard | Procedure: oth-mult | Contract: services | Deadline: 2029-02-23

Buyer: Ville de Saint-Cyr-en-Val | Notice type: cn-standard | Procedure: restricted | Contract: works | Deadline: 2029-02-23

Buyer: Многопрофилна болница за активно лечение "Национална кардиологична болница" ЕАД | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-26

Buyer: SIVON | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-26

Buyer: Iarnród Eireann-Irish Rail | Notice type: qu-sy | Procedure: neg-w-call | Contract: supplies | Deadline: 2029-02-28

Buyer: ЦЕНТЪР ЗА ПСИХИЧНО ЗДРАВЕ - ПЛОВДИВ ЕООД | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2029-02-28

Buyer: Pleno del Ayuntamiento de Ondara | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2029-02-28

Buyer: Pohjois-Pohjanmaan hyvinvointialue | Notice type: cn-social | Procedure: restricted | Contract: services | Deadline: 2029-02-28