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This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Tissue Interrogation Sites (TIS) to use highly integrated multi-modal analytic pipelines to interrogate human kidney biopsy tissue to discover and define new disease pathways and subgroups that enable precision clinical trials. All KPMP personnel will actively participate in scientific discovery and promote open science.

This Notice of Funding Opportunity (NOFO) requests applications for the Kidney Precision Medicine Project (KPMP) Central Hub (CH) to lead a unified effort to discover and define new acute and chronic kidney disease pathways and subgroups that enable precision clinical trials. The CH will provide strategic leadership for the entire KPMP and steward advanced computational analyses, data management and sharing, communication and outreach, and business operations to realize the vision of the KPMP. All KPMP personnel will actively participate in scientific discovery and promote open science.

The Transforming Pediatrics for Early Childhood Program (TPEC) will advance the U.S. Department of Health and Human Services" Make America Healthy Again (MAHA) priorities by preventing chronic disease early in life and promoting healthy development in early childhood. TPEC recipients - organizations with statewide or tribal reach - will place early childhood development (ECD) experts in local pediatric practices to deliver team-based care to young children and their families. Recipients will improve the quality and cost effectiveness of pediatric primary care by delivering a comprehensive team-based approach that focuses on factors critical to child development. Through this approach, pediatric primary care staff will: ​Screen families for their needs related to mental health, housing, nutrition, and child development; ​Build safe, stable, and nurturing relationships between caregivers and their children; ​Educate caregivers on developmental milestones and how to watch for them; and ​Make sure that families get referrals and access to additional or specialized support. TPEC recipients will:Place early childhood development (ECD) experts in pediatric practices that primarily serve families covered by Medicaid/Children"s Health Insurance Program (CHIP) and deliver high-quality ECD services using a team-based approach.Build the skills of pediatric primary care staff statewide to deliver high-quality ECD services using a team-based approach. Improve statewide administrative policies and financing strategies to expand and sustain team-based pediatric primary care, improving the....

The purpose of the Early Childhood Comprehensive Systems SEED Project: Scaling Effective Early Childhood Systems Development (ECCS SEED) is to address the root causes of chronic disease in early childhood by improving families" access to health care, screening kids early for physical and mental health needs, and connecting parents to services that enable them to provide for their children. The ECCS SEED Project will partner with states and communities to support evidence-based strategies that improve access to quality care for prenatal-to-age-5 (P-5) families and promote healthy child development and family well-being.

The NFLP seeks to increase the number of qualified nursing faculty nationwide by providing:Low-interest loans for students studying to be nurse faculty. Loan cancelation for graduates who go on to work as faculty. NFLP graduates can have up to 85 percent of their student loan and interest canceled if they work full-time as nurse faculty for up to four years. This includes Advanced Practice Registered Nurses (APRNs) who work full-time as preceptors in academic-practice partnerships.

The Rural Northern Border Region Network Planning (RNBR-NP) Program provides one-year funding to build new or strengthen existing healthcare networks in the Northern Border Region. RNBR-NP uses network development as a strategy for linking rural health care stakeholders together for greater collective capacity to overcome local challenges, expand access, and improve the quality of care in the rural communities these organizations serve.

This notice solicits applications for projects to implement integrated, community-based models that increase participation of underrepresented populations in lupus clinical trials across the full participation pathway, including awareness, referral, screening, enrollment and retention.

The Office of the Assistant Secretary for Health (OASH), Office of Population Affairs (OPA) anticipates the availability of funds for Fiscal Year (FY) 2026 grants under the authority of Division B of the Consolidated Appropriations Act, 2026 (Public Law No. 119–75). Through a competitive NOFO, OPA will seek applications to establish and operate a National Training Center for Teen Pregnancy Prevention (TPP) to provide training and technical assistance (TTA) to all OPA-funded TPP program recipients. All activities funded under this NOFO must be in compliance with statutory requirements and are expected to be in alignment with the Priorities of the Office of the Assistant Secretary for Health, available at https://health.gov/priorities.This funding opportunity aims to establish and operate a national training center (NTC) for TPP grant recipients that will provide TTA to build their capacity to effectively deliver high quality services and programs and have the greatest impact on meeting their project"s goals. The primary audience for the training center is OPA-funded TPP grant recipients. Many of these grant recipients rely on sub-recipients and partners to directly deliver services and implement programs, therefore OPA expects the funded training center to provide TTA at the grant recipient, sub-recipient, and implementation partner level to support grant recipient and the efforts of their network.

OPA"s Embryo Adoption Awareness and Services program aims to increase public awareness of embryo adoption as a method of family building and to provide individuals adopting embryos the medical and administrative services deemed necessary for such adoptions. Recipients of the EAA program should be individuals that are currently involved, soon may be involved, or are interested in adopting or donating embryos, and the medical facilities/providers involved in assisting those individuals with embryo adoption and donation.

The purpose of the NIA Career Transition Award (CTA) is to facilitate the transition of mentored researchers to tenure-track faculty conducting research that advances the mission of NIA. This three-year award provides protected time through salary and research support and is targeted at applicants who plan to start a tenure-track faculty position within a year of the award.

The Employment and Training Administration at the U.S. Department of Labor (DOL) is soliciting applications in support of the administration of the American History and Civics Education – National Activities (AHC-NA) program on behalf of the U.S. Department of Education (ED). The purpose of the AHC-NA program is to promote new and existing evidence-based strategies to encourage innovative American history, civics and government, and geography instruction, learning strategies, and professional development activities and programs for teachers, principals, or other school leaders, particularly such instruction, strategies, activities, and programs that benefit students from low-income backgrounds and other underserved populations. America"s 250th anniversary is a particularly appropriate time to promote innovative teaching and learning that unites our country, honors our history, promotes informed citizenship, and cherishes our freedom as we build the golden age of opportunity. ED encourages applications to include strong partnerships and active collaboration between eligible entities, local educational agencies, and State educational agencies in their design and proposed implementation. Project activities should reflect the best available research and practice in teaching and learning.

The U.S. Department of Housing and Urban Development"s Office of Policy Development and Research (PD&R) expects to release a Notice of Funding Opportunity for the Mass Market Solutions for Leveraging Robotics and AI Technologies for Home Construction Demonstration. This anticipated NOFO is intended to fund demonstration projects that test and scale the use of automation, robotics, and artificial intelligence in factory-built housing to help build homes faster, at lower cost, and in ways that can meaningfully increase housing supply.Awards are expected to be made as cooperative agreements, which means HUD will be actively involved throughout the project period. PD&R will provide technical guidance and oversight to help ensure projects are well designed, aligned with program goals, and able to generate lessons that can be applied more broadly across the housing industry.HUD is especially interested in projects that use automation, robotics, or AI at specific stages of the factory-built housing process, whether onsite or offsite. Eligible approaches may include panelized systems, modular construction, or fully volumetric homes. Projects must show that the proposed technology can produce housing components at a scale sufficient to deliver a defined number of homes and clearly explain how the technology improves construction speed, labor efficiency, quality, or cost.The overall goal of this NOFO is to support technologies that can move beyond a single pilot and be scaled for wider use, contributing to long-term increases in housing supply. Applicants should explain how their pro...

The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part D program is to provide family-centered care in outpatient or ambulatory care settings to low-income women (25 years and older) with HIV, infants (up to 2 years of age) exposed to or with HIV, children (ages 2 to 12) with HIV, and youth (ages 13 to 24) with HIV. The RWHAP Part D funding is intended to improve access to coordinated and comprehensive HIV medical care and support services). The services often include case management, behavioral health, nutrition services, and referrals to specialty care. As the only component of the RWHAP that supports services for affected individuals not living with HIV, Part D may fund services when the primary purpose is to enable the affected individual to participate in the care of a person with HIV, to directly remove barriers to care for the person with HIV, or to promote family stability.

Activities under this NOFO will focus on protecting and improving public health globally by: 1) strengthening public health laboratory systems; 2) improving public health laboratory workforce; 3) improving bio risk management; 4) reinforcing emergency laboratory preparedness in alignment with 7-1-7 outbreak response paradigm; 5) enhancing laboratory quality management systems and; 6) enhancing diagnostic capacity via rapid tests for low resource settings and genomic sequencing for pathogens of pandemic potential. Additionally, laboratory recipients previously funded under CDC-RFA-GH20-2109 may apply to expand efforts in additional countries with special consideration given to those countries.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NINDS R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs.

This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCC applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (h...

This Notice of Funding Opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi-site clinical trial (Phase Ill and beyond) application submitted underTEMP-26943. The DCC application must be specific to the collaborating Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of the NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of the NCCIH, applicants are encouraged to consult the NCCIH website: (http://www.nccih.nih.gov). Applicants are strongly encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase III and beyond) to study the effects of natural products (i.e. botanicals, probiotics, and products marketed as dietary supplements) in NCCIH designated areas of high research priority. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Applicants should describe plans for a Clinical Coordinating Center to develop and implement the proposed multi-site clinical trial. The objective of the Clinical Coordinating Center application is to provide the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. Clinical Coordinating Center applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. Clinical Coordinating Center applications submitted under this NOFO will utilize a two-phase, milestone-driven, cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center application, submitted under PAR-24-125, proposing a data analysis and data management plan for the clinical project is required. Both a Clinical Coordinating Center application and a corresponding Data Coordinating Center (DCC) application need to be submitt...

This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi site clinical trial (Phase III and beyond) application submitted under companion PAR-21-243. The DCC application must be specific to the companion Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website (http://www.nccih.nih.gov). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This Notice of Funding Opportunity (NOFO) aims to support new biomedical, behavioral, and social science investigators who are in the early stages of establishing independent careers in tobacco regulatory research. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of research methodology, and development of new research technology. Applicants are encouraged to conduct projects that ultimately have the potential to inform regulations on tobacco product manufacturing, distribution, and marketing. Research projects must address one or more High-Priority Research Topic(s) related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this NOFO will be administered by NIH using funds made available through FDA CTP and the FSPTCA. Research results from this NOFO are expected to generate findings and data directly relevant to informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.

Activities under this Notice of Funding Opportunity (NOFO) should focus on protecting and improving public health globally by: 1) strengthening public health surveillance systems; 2)improving the public health surveillance workforce; 3) improving the interface between public health disease surveillance and laboratory systems; 4) reinforcing emergency surveillance preparedness; 5) enhancing electronic disease surveillance platforms and systems; and 6)enhancing the use of surveillance data for public health action. This NOFO is intended to support global health security partners to develop or continue the implementation of surveillance activities that focus on protecting and improving public health globally through strategic planning, policy, strengthening surveillance capacities and systems through partnerships. These surveillance systems should build and improve regional and country capacities to detect, respond, control, and prevent infectious diseases and emerging threats; strengthen border health security; and mitigate public health events of international concern (PHEICs) or other global health issues. The implementing partner(s) will work closely with Ministries of Health, CDC country offices, and other stakeholders to assess existing surveillance systems, identify gaps, and propose solutions to enhance system performance. Activities will include the development and adaptation of protocols, training materials, and guidance documents, as well as the integration of surveillance data into actionable insights for decision-making. The partner will also support cross-sectora...

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

The purpose of this Notice of Funding Opportunity (NOFO) is to stimulate HIV/AIDS research within the scientific mission areas of the National Institute on Deafness and Other Communications Disorders (NIDCD). Applications should address high priority HIV/AIDS research outlined by the NIH Office of AIDS Research (OAR) (https://www.oar.nih.gov/hiv-policy-and-research/research-priorities) in the areas of hearing, balance, taste, smell, voice, speech, and language.For applications proposing a clinical trial, only low risk clinical trials will be supported.

The purpose of the Rehabilitation Engineering Research Centers (RERC) program is to improve the effectiveness of services authorized under the Rehabilitation Act by conducting advanced engineering research on and development of innovative technologies that are designed to solve particular rehabilitation problems or to remove environmental barriers. The purpose of this RERC is to conduct research on, develop, and evaluate Artificial Intelligence (AI)-driven assistive and rehabilitation technologies that enhance independence, participation, and quality of life for people with disabilities. Many existing assistive and rehabilitation technologies lack adaptability, personalization, and seamless integration into daily life. AI and machine learning (ML) offer trans-formative potential to address these gaps by enabling smarter, more responsive, and individualized assistive and rehabilitation technologies. AI-driven innovations in assistive and rehabilitation technology can shift them from static tools to dynamic, intelligent systems that continuously learn and adapt in real time to individual preferences, needs, and changing abilities. This grant will have a 60-month project period, with five 12-month budget periods.

​​The Public Health Training Center (PHTC) Program aims to increase the knowledge of the public health workforce through traineeships, specialized training and professional development in partnership with state and local health departments, community-based primary care providers, and related organizations (including non-traditional partners) to address public healthcare needs.​