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The purpose of this Funding Opportunity Announcement (FOA) is to stimulate HIV/AIDS research within the scientific mission areas of the National Institute on Deafness and Other Communications Disorders (NIDCD). Applications should address high priority HIV/AIDS research outlined by the NIH Office of AIDS Research (OAR) [https://www.oar.nih.gov/hiv-policy-and-research/research-priorities] in the areas of hearing, balance, taste, smell, voice, speech, and language.For applications proposing a clinical trial, only low risk clinical trials will be supported.

The purpose of this notice of funding opportunity (NOFO) is to support translational and clinical research to (1) advance precision medicine in pregnant women, lactating women, and children through the development of novel tools, models, and other technologies that could have a direct clinical or health impact; (2) enhance the understanding of the underlying mechanisms of drug action, including the role of pediatric ontogeny and the dynamic physiological changes that occur during pregnancy and lactation; and (3) discover and develop novel therapeutics or enhance the usage of existing drugs or drug repurposing for safer and more effective medications in pregnant and lactating women, neonates, and children. The overall goal is to improve safe and effective precision therapeutics for pregnant and lactating women, fetuses, neonates, and children, including those with disabilities.

The purpose of this notice of funding opportunity (NOFO) is to expand the network of institutes working with CDC to help eliminate or control non-malaria parasitic threats and neglected tropical diseases (NTDs). This NOFO will focus on threats and diseases that may affect Americans at home or abroad or whose elimination or control would serve other U.S. priorities. This program will also support research that will provide tools and information to improve NTD and parasitic disease program activities. The program will also integrate evaluation and surveillance activities for multiple NTDs and other parasitic diseases.

The Office of Refugee Resettlement (ORR) provides temporary housing and care for children who arrive in the United States alone. These are children who are under 18 years old, don't have legal permission to be in the U.S., and don't have a parent or legal guardian in the U.S. who can take care of them. ORR runs the Home Study and Post-Release Services Program to help these children. Before placing a child with a sponsor, ORR carefully checks potential homes to make sure they're safe and appropriate. After placement, ORR provides ongoing support to help children and their sponsors succeed. This support helps children adjust to living with their sponsor, connect with their community, stay safe and healthy, and navigate the immigration court process. The goal is to make sure children are placed in safe homes and have the support they need to thrive while their immigration cases move forward.

The purpose of this notice of funding opportunity (NOFO) is to support translational and clinical research to (1) advance precision medicine in pregnant women, lactating women, and children through the development of novel tools, models, and other technologies that could have a direct clinical or health impact; (2) enhance the understanding of the underlying mechanisms of drug action, including the role of pediatric ontogeny and the dynamic physiological changes that occur during pregnancy and lactation; and (3) discover and develop novel therapeutics or enhance the usage of existing drugs or drug repurposing for safer and more effective medications in pregnant and lactating women, neonates, and children. The overall goal is to improve safe and effective precision therapeutics for pregnant and lactating women, fetuses, neonates, and children, including those with disabilities.

The Center for Inherited Disease Research (CIDR) high-throughput genotyping, sequencing and supporting statistical genetics services are designed to aid the identification of genes or genetic modifications that contribute to human health and disease or to enhance existing collections of well-phenotyped specimens in biorepositories by the addition of genotype or next-generation sequence data. The laboratory specializes in genomic services that cannot be efficiently carried out in individual investigator laboratories. CIDR provides the most up-to-date platforms, services and statistical genetic support. This is an NIH-wide initiative that is managed by NHGRI. Information about current services offered can be accessed via: http://www.cidr.jhmi.edu.

​​The Rural Residency Planning and Development (RRPD) program improves and expands rural health care access. It does this by developing new, accredited, sustainable rural residency programs, including rural track programs (RTPs). ​Newly created rural physician residency programs increase training and ultimately practice in rural areas to address physician shortages. ​The RRPD program provides start-up funding to create new rural residency programs in qualifying medical specialties. Long-term sustainability funding must come from viable and stable sources, such as Medicare, Medicaid, and other public or private sources. ​Qualifying medical specialties are:​Family medicine.​Internal medicine.​Preventive medicine.​Psychiatry.​General surgery.​Obstetrics and gynecology.​For this notice of funding opportunity (NOFO), rural residency programs:​Are accredited physician residency programs.​Train residents in clinical training sites that are physically located in a rural area as defined by HRSA"s Federal Office of Rural Health Policy (FORHP) for greater than 50 percent of their total time in residency.​Focus on preparing physicians to practice in rural communities.

This notice announces the opportunity to apply for funding under the Rural Health Clinic Technical Assistance Program. The Rural Health Clinic Technical Assistance (RHC TA) Program funds an entity to provide technical assistance (TA) to Rural Health Clinics (RHCs) through targeted support, specialized expertise, and guidance. The purpose of this program is to:Identify key policy, regulatory, programmatic, and clinical issues facing RHCs.Inform RHCs and other rural stakeholders about key RHC issues that affect, or could affect, health care delivery and improve care. Identify and disseminate information on tools, resources, and strategies as possible solutions to challenges faced by RHCs.

​​This notice announces the opportunity to apply for funding under the Rapid Response Rural Data Analysis and Issue Specific Rural Research Studies Program. This program will fund one entity to provide rural stakeholders with timely access to data analysis on pressing rural health issues. The goal of this award is to fund analysis that furthers understanding on emerging factors that affect rural health to improve health care in rural America. ​

Rural Communities Opioid Response Program (RCORP)-Planning supports organizations in rural communities to build the partnerships and foundational capacity needed to develop, implement and sustain a comprehensive system of substance use disorder (SUD) and related services. RCORP"s focus is on opioid misuse and its impact on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Individuals struggling with SUD, including opioid use disorder (OUD), need a continuum of mental, behavioral, and related social supports. RCORP-Planning helps address these needs in a comprehensive way.This program is intended for rural communities that may find the logistics or requirements of larger, more complex federal grant programs to be barriers to accessing start-up support. Funding will serve as a critical first step to creating SUD service systems that make care easy to access, strengthen the behavioral health workforce, and have strong community buy-in. It will help prepare communities to provide sustainable prevention, treatment, recovery, and other supportive services that:reduce substance use initiation and misuse,address the mental, behavioral, and psychosocial needs of people who use illicit substances or misuse alcohol, or are in recovery from substance use problems, andreduce disease and death related to substance use problems, including OUD, in high-risk rural communities.The intent of this program is to fund planning activities only. Funds may not be used for direct service delivery.

The Rural Communities Opioid Response Program (RCORP)–Impact funds rural communities to drive measurable improvements in access to integrated, coordinated treatment and recovery services for substance use disorder (SUD), including opioid use disorder (OUD). Its long-term aim is to reduce morbidity and mortality associated with SUD and enable sustained recovery and well-being.The program supports:New or expanded evidence-based SUD prevention, treatment, and recovery services in rural areas;Coordination across health and supportive social services to enable sustained, long-term recovery;A larger, more responsive workforce to address SUD-related needs; andMulti-sector community networks to strengthen and sustain local service delivery.The focus of RCORP-Impact is on reducing the impact of opioid misuse on rural America. However, HRSA recognizes that people who misuse opioids often struggle with other substances as well, including alcohol. Therefore, RCORP-Impact supports a comprehensive approach to address all SUD, including OUD, within a continuum of mental, behavioral, and related social supports.

The Telehealth Nutrition Services Network Grant Program will support telehealth networks that improve access to quality health care services through telehealth technology. This program will use telehealth nutrition services to help prevent and manage chronic diseases.

​​This notice announces the opportunity to apply for funding under the Rural Health Research Dissemination Program. The purpose of this program is to fund an entity to disseminate and promote rural health services research to broad audiences, such as decision makers and rural stakeholders at national, state, and community levels. FORHP funds health services research through the Rural Health Research Center (RHRC) Program and other cooperative agreements. The successful applicant for this program will develop and maintain a website that catalogs this research so that it is easily and freely accessible to the public. The successful applicant will also develop and maintain strategies to disseminate this research through a variety of innovative mechanisms including (but not limited to) a listserv, social media accounts, presentations, and exhibits at national conferences, and webinars.​

The Technology-enabled Collaborative Learning Program will support the use of technology-enabled collaborative learning to improve retention of health care providers and increase access to health care services in rural and underserved areas and populations.

The purpose of the Rural Community Health Support Program cooperative agreement is to develop, deliver, and coordinate nationally available technical assistance that supports community-based organizations and rural health stakeholders serving rural populations to improve and expand delivery and access to quality care for rural communities.

This announcement (NOFO) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols.The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies.Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA.

The purpose of the notice of funding opportunity (NOFO) is to solicit applications for a Coccidioidomycosis Collaborative Research Centers (CCRC) program. This new initiative will establish highly collaborative, multi-disciplinary, research teams to conduct translational and clinical research to support the development of a Valley fever vaccine as outlined in NIAID's Strategic Plan for Research to Develop a Valley fever Vaccine.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program.

This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invites an application from an eligible organization to apply. Please see Section III. Eligibility for additional information. The NHLBI is announcing its intent to issue a single source cooperative agreement to Northwestern University. This NOFO solicits a renewal of the Data Translation Center for an ongoing NHLBI phenomics program, HeartShare, to coordinate the overall project, continue to oversee enrollment of a cohort of patients with heart failure with preserved ejection fraction (HFpEF), curate and analyze prospective deep phenotyping data, and support planning, implementation, and data analysis for clinical trials. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.Companion NOFO RFA-HL-27-008 will support Clinical Centers for recruitment and follow-up of heart failure patients and a Clinical Trial Center for new clinical trial activities.

This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. Only current award recipients will be eligible to apply. This NOFO seeks two separate U24 applications to renew the Adolescent Brian Cognitive Development (ABCD) Research Coordinating Center (CC) and the Data Analysis Informatics and Resource Center (DAIRC) to extend study visits into young adulthood. This renewal called Adolescent Brain Cognitive Development – Extended (ABCD-E) study is critical to be able to follow these youth through their emerging adulthood, when many of the outcomes of interest (e.g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The structure of the ABCD-E study Consortium shall consist of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single central Data Analysis, Informatics, and Resource Center, and (3) a single overall Coordinating Center. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for research project sites (RFA-DA-27-002). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. Only current award recipients will be eligible to apply. This NOFO seeks linked collaborative U01 applications to renew the current Adolescent Brain Cognitive Development (ABCD) Research Project Sites to extend study visits into young adulthood. This renewal, called Adolescent Brain Cognitive Development – Extended (ABCD-E) study, is critical to be able to follow these youth into emerging adulthood, when many of the outcomes of interest (e.g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The structure of the ABCD-E study Consortium shall consist of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single central Data Analysis, Informatics, and Resource Center, and (3) a single overall Coordinating Center. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for two centers (RFA-DA-27-003). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

The purpose of this notice of funding opportunity (NOFO) is to support applications for the Tuberculosis (TB) Research Advancement Centers (TRACs) program. The goal of the TRACs is to develop the next generation of TB researchers and to catalyze multidisciplinary and innovative TB science by providing expertise and resources to facilitate basic and clinical TB research.

This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidisciplinary program titled "Accelerating Product Excellence in Innovation and for Clinical Adoption" (APEx), that will facilitate advancement of promising strategies and products for tissue engineering and regenerative medicine (TE/RM). APEx will be composed of Resource Centers (RCs) and associated Interdisciplinary Translational Projects (ITPs) in the area of therapeutics (including adult stem cell-based treatments), sensors, and diagnostics. RCs will capitalize on their available clinical, scientific, industrial, regulatory and commercialization expertise, to deliver technical support, research capacity, administrative infrastructure and regulatory and commercialization support to the ITPs and guide them to complete pre-clinical studies toward initiation of clinical trials. During this funding cycle, APEx will complete validation, manufacturing, and preclinical testing of the most promising products, which may include, but are not limited to products for detecting or treating tissue damage caused by congenital defect, traumatic injury, or chronic disease. Products that support early detection of chronic pathologies, monitoring of validated biomarkers of health or disease, as well as approaches to reduce or prevent resulting damage, are especially encouraged. The outcome of APEx will be TE/RM products with their regulatory approvals in place for first-in-human studies, along with associated clinical study protocols, and synthesis and manufacturing protocols rea...

The purpose of the NINDS Child Neurology Career Development Program (CNCDP) is to facilitate and support the research career development of physicians specialized in Child Neurology who have made a commitment to independent research careers. The CNCDP is a single national program, implemented by one or more PD/PIs, together with an advisory committee composed of basic and clinical investigators who have a strong record of funded research and successful training of physicianscientists. The CNCDP will generally provide three consecutive years of support to individuals to provide them with the knowledge, tools and research experience that will enable them to develop a significant research project funded by an individual career development award or research grant.

This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Recruitment Sites (RS) to enroll people with Acute Kidney Injuries (AKI) and/or Chronic Kidney Diseases (CKD) into a longitudinal biopsy cohort study. Under-enrolled populations (e.g., AKI) and comprehensive phenotyping remain priorities. New opportunities include clinical biopsies with residual tissue for research, enhanced physiologic phenotyping, repeat biopsies, pediatric recruitment, and collection of healthy reference tissue. All KPMP personnel will actively participate in scientific discovery and promote open science.