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The Tribal Colleges and Universities Program (TCUP) provides awards to federally recognized1 Tribal Colleges and Universities, Alaska Native-serving institutions, and Native Hawaiian-serving institutions to promote high quality science (including sociology, psychology, anthropology, linguistics, economics and bioeconomics, statistics, and other social and behavioral sciences; natural sciences; computer science, including, but not limited to, artificial intelligence, quantum information science, and cybersecurity), technology, engineering and mathematics (STEM), STEM education, research, and outreach. Support is available to TCUP-eligible institutions (see the Additional Eligibility subsection of Section IV of this solicitation) for transformative capacity-building or community engagement projects through Instructional Capacity Excellence in TCUP Institutions (ICE-TI), Targeted STEM Infusion Projects (TSIP),TCUP for Secondary and Elementary Teachers in STEM (TSETS), TCU Enterprise Advancement Centers (TEA Centers), Cyberinfrastructure Health, Assistance, and Improvements (CHAI), and Preparing for TCUP Implementation (Pre-TI). Collaborations led by TCUP institutions that involve non-TCUP institutions of higher education are supported through TCUP Partnerships, with the participation of other NSF programs to support the work of non-TCUP institutions. Finally, research studies that further the scholarly activity of individual faculty members are supported through Small Grants for Research (SGR). Through the opportunities highlighted above, as well as collaborations with other N...

The Pathways to Enable Secure Open-Source Ecosystems (PESOSE) program supports the translation of open-source science and engineering-focused research products into safe and sustainable ecosystems that address national and societal challenges. Open-source tools such as software, hardware, machine learning models, languages, and data platforms are designed to be shared as they are publicly-accessible and modifiable. These tools spark innovation in critical fields as varied as artificial intelligence (AI) and cloud computing, banking, healthcare, research, education, next-gen manufacturing, mobility, and National security (including cybersecurity). PESOSE supports the creation of managing organizations for these ecosystems, ensuring strong governance, distributed development, and broad user communities across academia, industry, and government. PESOSE also supports enhancements to the safety, security, and privacy of Open-Source Ecosystems (OSE) by addressing significant vulnerabilities, both technical and socio-technical, to improve the resistance of the ecosystem against threats. This solicitation seeks three types of proposals, allowing teams to propose specific activities to:1) scope and planthe establishment of an OSE, 2)establishand expand a sustainable OSE based on a robust, promising open-source product that meets an emergent societal or national need, and 3) improve the safety, security, and privacy of an existing OSE and its products.

Summary: The fiscal year 2026 (FY26) Lung Cancer Research Program (LCRP) Patient-Centered Outcomes and Survivorship Award (PCOSA) promotes evidence-based and patient-centered approaches to improve health and lung cancer related outcomes and enhance the patient experience in defined populations. Research must address at least one of the FY26 LCRP areas of emphasis in the Health Outcomes and Survivorship category.Distinctive Features:• This funding mechanism requires the research team to include an advocate who is a lung cancer patient/survivor or caregiver.• This funding mechanism allows proposed projects to include translational or clinical research, including pilot clinical trials.

Summary: The fiscal year 2026 (FY26) Lung Cancer Research Program (LCRP) Translational Research Award (TRA) supports advanced translational research that will foster transformation of promising ideas in lung cancer into clinical applications. Research must address at least one of the FY26 LCRP areas of emphasis.Distinctive Features: This funding mechanism intends to support a broad range of translational studies and allows application submission under: Funding Level 1 – Advanced/late-stage preclinical work or correlative studies; or Funding Level 2 – Pilot clinical trials of novel interventions.

Summary: The fiscal year 2026 (FY26) Lung Cancer Research Program (LCRP) Idea Development Award (IDA) supports conceptually innovative, high-risk/high-reward research that could lead to critical discoveries or major advancements that will accelerate progress toward eradicating deaths and suffering from lung cancer. This mechanism promotes new ideas that are in the early stages of development and have the potential to yield impactful data and new avenues of investigation. Research must address at least one of the FY26 LCRP areas of emphasis.Distinctive Features: This FY26 LCRP IDA mechanism has a New Investigator category that is designed to allow applicants early in their faculty appointments to compete for funding separately from established investigators. Preliminary data to support the feasibility of the research hypotheses and research approaches are required; however, these data do not necessarily need to be derived from studies of lung cancer.

Summary: The fiscal year 2026 (FY26) Prostate Cancer Research Program (PCRP) Data Science Award (DSA) supports research that develops or uses quantitative and analytical approaches, processes and/or systems to obtain knowledge and insight from large and/or complex sets of prostate cancer data in one or more of the following research areas: Analysis of clinically annotated datasets; analysis of -omics data; artificial intelligence and machine learning; bioinformatics; computational biology; digital pathology; epidemiology; and medical imaging. All applications must address one of the FY26 PCRP Overarching Challenges. Distinctive Features: This funding mechanism allows for multiple Principal Investigators (PIs). Only the initiating PI will submit a pre-application, but all PIs will need to submit full applications. The partnering PI application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.

Summary: The fiscal year 2026 (FY26) Prostate Cancer Research Program (PCRP) Early Investigator Research Award (EIRA) supports prostate cancer research conducted by investigators in the early stages of their careers with guidance from an experienced mentor. All applications must address one of the FY26 PCRP Overarching Challenges. Distinctive Features: ·        Early-Career Investigator: Serves as the principal investigator. Includes investigators possessing a doctoral degree or equivalent with fewer than three years of postdoctoral research experience at the application submission deadline, excluding clinical residency or clinical fellowship training. ·        Mentorship: Applications must include at least one mentor who demonstrates experience in prostate cancer research and successful mentorship. ·        Researcher Development Plan: Applications must include a researcher development plan articulating an individualized strategy for acquiring necessary skills, competence, and expertise to complete the project and foster the Principal Investigator’s (PI’s) career development

Summary: The fiscal year 2026 (FY26) Prostate Cancer Research Program (PCRP) Physician Research Award (PRA) Supports a mentored research experience to prepare physicians with clinical duties for careers in prostate cancer research. All applications must address one of the FY26 PCRP Overarching Challenges. Distinctive Features: ·        Early-Career Clinician Investigator: Serves as the Principal Investigator (PI). Includes investigators with clinical duties in the last year of an accredited medical residency or medical fellowship program, or within five years of initiating a faculty appointment. ·        Mentorship: Applications must include at least one mentor who demonstrates experience in prostate cancer research and successful mentorship. ·        Researcher Development Plan: Applications must include a research development plan articulating an individualized strategy for acquiring necessary skills, competence and expertise to complete the projects and foster the PI’s career development. https://cdmrp.health.mil/pubs/press/2026/pcrppreann

Summary: The fiscal year 2026 (FY26) Prostate Cancer Research Program (PCRP) Idea Development Award (IDA) supports new ideas that represent innovative approaches to prostate cancer research and have the potential to make an important contribution to the PCRP mission. All applications must address one of the FY26 PCRP Overarching Challenges. Distinctive Features: ·        New Investigator Category: In addition to established investigators, the FY26 PCRP Idea Development Award encourages research ideas from investigators in the early stages of their careers (i.e., within 10 years after completion of their terminal degree). Qualified new investigators must identify a collaborator(s) experienced in prostate cancer research.   https://cdmrp.health.mil/pubs/press/2026/pcrppreann

Revolutionizing Engineering Departments (hereinafter referred to as RED) is designed to build upon previous efforts in engineering education research. Specifically, previous and ongoing evaluations of the NSF Engineering Education and Centers Division program and its predecessors, as well as those related programs in the Directorate for STEM Education, have shown that prior investments have significantly improved the first year of engineering students’ experiences, incorporating engineering material, active learning approaches, design instruction, and a broad introduction to professional skills and a sense of professional practice – giving students an idea of what it means to become an engineer. Similarly, the senior year has seen notable change through capstone design experiences, which ask students to synthesize the technical knowledge, skills, and abilities they have gained with professional capacities, using reflective judgment to make decisions and communicate these effectively. However, this ideal of the senior year has not yet been fully realized, because many of the competencies required in capstone design, or required of professional engineers, are only partially introduced in the first year and not carried forward with significant emphasis through the sophomore and junior years. The Directorates for Engineering (ENG) and STEM Education (EDU) are funding projects as part of the RED program, in alignment with the Improving Undergraduate STEM Education (IUSE) framework and Professional Formation of Engineers (PFE) initiative. These projects are designing revolutionar...

The NSF Research Traineeship (NRT) program seeks proposals that explore ways for graduate students in research-based master’s and doctoral degree programs to develop the skills, knowledge, and competencies needed to pursue a range of STEM careers. The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary or convergent research areas, through a comprehensive traineeship model that is innovative, evidence-based, and aligned with changing workforce and research needs. Proposals are requested that address any interdisciplinary or convergent research theme of national priority, as described in section II.D below. The NRT program addresses workforce development, emphasizing broad participation, and institutional capacity building needs in graduate education. The program encourages proposals that involve strategic collaborations with the private sector, non-governmental organizations (NGOs), government agencies, national laboratories, field stations, teaching and learning centers, informal science centers, and academic partners. NRT especially welcomes proposals that reflect collaborations between NRT proposals and existing NSF Eddie Bernice Johnson Inclusion across the Nation of Communities of Learners of Underrepresented Discoverers in Engineering and Science (INCLUDES) Initiative, Research Experiences for Undergraduates (REU), Louis Stokes Alliances for Minority Participation (LSAMP), NSF Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM), and NSF STEM Ed Organizational Postdoctoral Fellowship program (ST...

The National Science Foundation (NSF) and the National Institutes of Health (NIH) are interested in proposals that will propel our understanding of the biomedical research enterprise by drawing from the scientific expertise of the science of science policy research community. NSF promotes the progress of science by maintaining the general health of research and education across all fields of science and engineering. The Social, Behavioral and Economic Sciences (SBE) Directorate within NSF supports basic research on people and society. The SBE sciences focus on human behavior and social organizations; how social, economic, political, cultural and environmental forces affect the lives of people from birth to old age; and how people in turn shape those forces. SBE's Science of Science: Discovery, Communication and Impact Program (SoS:DCI) supports research designed to advance the scientific basis of science and innovation policy. The NIH is the U.S. federal agency charged with supporting biomedical research in the U.S.The National Institute of General Medical Sciences (NIGMS) within the NIH supports basic biomedical research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. Both NSF and NIH believe that there are opportunities and needs for building and supporting research projects with a focus on the scientific research enterprise. The two agencies also recognize that when programmatic goals are compatible, coordinated management and funding of a research program can have a positive synerg...

The NSF CISE Directorate supports research and education projects that develop new knowledge in all aspects of computing, communications, and information science and engineering through the following Future Computing Research (Future CoRe) programs: Algorithmic Foundations (AF) program; Communications and Information Foundations (CIF) program; Computer Systems Research (CSR) program; Computing Education Research (CER) program; Cyber-Physical System Foundations and Connected Communities (CPS) program; Foundations of Emerging Technologies (FET) program; Human-Centered Computing (HCC) program; Information Integration and Informatics (III) program; Networking Technology and Systems (NeTS) program; Robust Intelligence (RI) program;and Software and Hardware Foundations (SHF) program; The CISE Future Computing Research program anticipates a portfolio of awards with a range of budgets and durations, including projects of smaller scope. Project durations and budgets must be commensurate with the scope of the proposed work up to the maximum limit of $1,000,000 with a duration up to 4 years. Typical projects are approximately $150,000 to $250,000 per year and are 3 to 4 years in duration. Projects are discouraged from exceeding $300,000 in any single year. Estimated program budget, number of awards, and average award size/duration are subject to the availability of funds.

Summary: The fiscal year 2026 (FY26) Hearing Restoration Research Program (HRRP) Focused Research Award (FRA) supports promising research that accelerates drug discovery and therapeutic development for hearing restoration after military-relevant auditory system injury. The FRA may be used to support preclinical studies and/or clinical research. Research must align with at least one of the FY26 HRRP Focus Areas. The FRA cannot be used to support clinical trials, tinnitus research or vestibular research.Distinctive Features:• The FRA offers two Funding Levels to support research at different stages and the exploration/development of ideas of different maturity levels.• Funding Level 2 includes a Partnering Principal Investigator (PI) Option (PPIO) for two PIs, an Initiating PI and a Partnering PI.• Scored peer review criteria include Research Idea/Rationale, Research Strategy and Feasibility, Impact, and Personnel.• Programmatic review criteria include adherence to the intent of the FRA, contribution to the HRRP portfolio, relative impact, and relevance to military health.

Summary: The fiscal year 2026 (FY26) Vision Research Program (VRP) Mentored Clinical Research Award (MCRA) supports patient-oriented vision injury research conducted by highly motivated military or civilian clinicians in training. The MCRA may be used to support a standalone study of high impact to vision injury care or the generation of clinical research data in preparation for a more expansive study. Research must align with at least one of the FY26 VRP Focus Areas. The MCRA may not be used to support preclinical research or clinical trials. Distinctive Features: ·        Key personnel must include an established clinician or Ph.D. clinical scientist, who will serve as Principal Investigator (PI) and a clinician in training (e.g., a fellow, resident, junior clinician, clinician in a Ph.D. program), who will conduct the proposed research under mentorship of the PI, with support from supporting personnel as appropriate. ·        The clinician in training should have sufficient time remaining in their training program to complete the research proposed under the MCRA.  ·        Scored peer review criteria include Research Idea/Rationale, Research Strategy and Feasibility, Impact and Personnel. ·        Programmatic review criteria include adherence to the intent of the MCRA, contribution to program portfolio, relative impact and relevance to military health. ·        Applicants must submit documentation of Institutional Review Board (IRB)/Ethics Committee (EC) approval or exemption by January 1, 2027, in order for the MCRA application to be considered for funding.  https://cd...

Summary: The fiscal year 2026 (FY26) Neurofibromatosis Research Program (NFRP) Neurofibromatosis Research Academy – Leadership Award (NFRALA) supports visionary, established neurofibromatosis (NF) investigators with documented history of neurofibromatosis funding, publications, strong mentorship and commitment to leadership to serve as Director and Deputy Director of the Neurofibromatosis Research Academy. The Academy Director and Deputy Director will execute a multi-institutional, interactive, virtual research academy that consists of scholars, who are early-career investigators, and their career guides, who serve as the scholars’ primary mentors.Distinctive Features:• Academy Director: Established NF investigators at or above the level of Associate Professor, or equivalent, at the full application submission deadline.• Academy Deputy Director: Investigators at or above the level of Associate Professor, or equivalent, at the full application deadline and affiliated with a different institution than the Academy Director.• Pilot Research Project: The Academy Director and Deputy Director will conduct one or more pilot research projects in collaboration with the academy scholars. Preliminary and/or published data relevant to NF and the proposed research project are encouraged but not required.

This funding partnership between the National Science Foundation (NSF) and the National Endowment for the Humanities (NEH) supports projects to develop and advance knowledge concerning dynamic language infrastructure in the context of endangered human languages — languages that are both understudied and at risk of falling out of use. Made urgent by the imminent loss of roughly half of the approximately 7,000 currently used languages, this effort aims to exploit advances in human-language technology to build computational infrastructure for endangered language research. The program supports projects that contribute to data management and archiving, and to the development of the next generation of researchers. Funding can support fieldwork and other activities relevant to the digital recording, documentation and analysis, and archiving of endangered language data, including the preparation of lexicons, grammars, text samples, and databases. Funding is available in the form of one- to three-year senior research grants and conference proposals. Fellowship support is available through a separate funding opportunity administered by NEH. Note: a conference proposal should generally be submitted at least a year in advance of the scheduled date of the conference. For additional information about creating and submitting conference proposals, please refer to PAPPG Chapter II. E.9.

The Probability Program supports research on the theory and applications of probability. Subfields include discrete probability, stochastic processes, limit theory, interacting particle systems, stochastic differential and partial differential equations, and Markov processes. Research in probability which involves applications to other areas of science and engineering is especially encouraged. Conferences Principal Investigators should carefully read the program solicitation "Conferences and Workshops in the Mathematical Sciences" (link below) to obtain important information regarding the substance of proposals for conferences, workshops, summer/winter schools, and similar activities. Conference and workshop proposals should be submitted eight months before the requested start date.

To support activities that develop, expand, strengthen, or sustain NIST partnership programs and/or support the conduct of research or a recipient's portion of collaborative research in a variety of areas including, but not limited to: Metrology; Standards; Nanotechnology; Artificial Intelligence; Advanced Communications; Advanced Manufacturing; Promotion of U.S. innovation and industrial competitiveness; Measurements in Sciences; Neutron Research; and enhancing coordination of the U.S. Standards System with government and private sector organizations.

Summary: The fiscal year 2026 (FY26) Reconstructive Transplant Research Program (RTRP) Concept Award supports the exploration of highly innovative new concepts or untested theories that address an important problem relevant to reconstructive transplantation. The Concept Award does not support clinical trials. Distinctive Features: ·        Innovation: Innovative research may introduce a new paradigm, challenge existing paradigms, examine existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative. ·        Relevance: Projects should address at least one of the FY26 RTRP Focus Areas. ·        Preliminary Data: Presentation of preliminary data is not allowed; however, applications should demonstrate the ability to achieve interpretable results. A rationale for the proposed work must be provided. ·        Early-Career Investigators: Early-career investigators are encouraged to apply. Investigators at or above the level of postdoctoral fellow are eligible to apply.

NTIA is soliciting applications for funds remaining under the Tribal Broadband Connectivity Program (TBCP), authorized by the Consolidated Appropriations Act, 2021, Division N, Title IX, Section 905(c), Public Law 116-260, 134 Stat. 1182 (Dec. 27, 2020) (Act), as amended by the Infrastructure Investment and Jobs Act, Division F, Title II, Section 60201, Public Law 117-58, 135 Stat. 429 (Nov. 15, 2021) (IIJA) (codified at 47 U.S.C. §1705). TBCP provides funding for grants to Eligible Entities to expand access to and adoption of: (i) broadband service on Tribal Land; or (ii) programs that promote remote learning, telework, or telehealth resources.

NTIA is soliciting applications for the Native Entities Grant Program (“Program”), authorized by the Infrastructure Investment and Jobs Act of 2021, Division F, Title III, Public Law 117-58, 135 Stat. 429, 1209 (November 15, 2021) (codified at 47 U.S.C. §1701, 1721, et seq.) (the “Digital Equity Act of 2021” or “Act”). The Act authorizes two programs that set aside funds for Indian Tribes, Alaska Native entities, and Native Hawaiian organizations (collectively “Native Entities”): the “State Digital Equity Capacity Grant Program” and the “Digital Equity Competitive Grant Program.” To reduce administrative burden and cost, NTIA is releasing the funds for both programs through a single application process.

The Division of Mathematical Sciences (DMS)in the Directorate for Mathematical and Physical Sciences (MPS) at the National Science Foundation (NSF)and the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH)plan to support fundamental research in mathematics and statistics necessary to answer questions in the biological and biomedical sciences. Both agencies recognize the need to promote research at the interface between mathematical and life sciences. This program is designed to encourage new collaborations, as well as to support innovative activities by existing teams. The joint DMS/NIGMS initiative offers two submission tracks: Track 1 - for projects with a total budget of up to $600,000 for an award duration of 3 years, and Track 2 - for projects with a total budget of up to $1,200,000 for an award duration of 3-4 years.

Summary: The fiscal year 2026 (FY26) Duchenne Muscular Dystrophy Research Program (DMDRP) Idea Development Award (IDA) promotes new ideas that are still in the early stages of development and have the potential to yield impactful data and new avenues of investigation. This award supports impactful, high-risk/high-reward research that could lead to critical discoveries or major advancements that will accelerate progress in improving outcomes for individuals with Duchenne muscular dystrophy (DMD) in the near term. Applications should include a well-formulated, testable hypothesis based on strong scientific rationale. The DMDRP strongly encourages research projects investigating therapies designed to demonstrate efficacy cross the life span, including infants, toddlers and nonambulatory individuals.Distinctive Features: The FY26 DMDRP IDA mechanism offers three eligibility career categories:• The Established Investigator category is for independent investigators at all academic levels, or equivalent• The New Investigator – Early-Stage category is for independent investigators early in their careers (i.e., within 10 years of their first faculty appointment or equivalent). Applicants in this category will be reviewed separately from Established Investigators.• The New Investigator – Transitioning category is for independent investigators at all academic levels, or equivalent, in an area other than muscular dystrophy who are seeking to transition to a career in DMD, thereby bringing their expertise to the field. Applicants in this category will be reviewed separately from Establi...

Summary: The fiscal year 2026 (FY26) Duchenne Muscular Dystrophy Research Program (DMDRP) Clinical/Translational Research Award (CTRA) supports advanced translational research to accelerate promising ideas in Duchenne muscular dystrophy (DMD) research toward clinical applications. Research must address at least one of the FY26 CTRA Focus Areas. Research projects investigating therapies that will be efficacious across the life span are strongly encouraged.Distinctive Features: The FY26 CTRA offers two funding levels:• Funding Level 1 to support smaller, less complex preclinical and/or clinical research.• Funding Level 2 to support larger, more complex preclinical and/or clinical research.The FY26 CTRA also offers a Partnering PI Option (PPIO) to support meaningful and productive partnerships between two investigators collaborating on the proposed research project. The PPIO has two eligibility categories:• Early-Career Partnering PI category for an independent, early-career investigator within 10 years of their first faculty appointment (or equivalent) by the time of application submission.• Established Interdisciplinary Partnering PI for independent investigators at all academic levels, or equivalent, in an area other than muscular dystrophy, seeking to transition to a career in DMD, thereby bringing their expertise to the field.Preliminary data are required for all applications. Pilot clinical trials and clinical trial readiness studies to better inform development of drugs, devices, and other interventions are allowed.