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The objective of the NIH Career Transition Award (K22) is to provide support to outstanding basic or clinical investigators to develop their independent research skills through a two phase program: an initial period involving an intramural appointment at the NIH and a final period of support at an extramural institution. This NINDS K22 is specifically designed to facilitate the transition of NINDS intramural neurologist- and neurosurgeon-scientists to independent, academic faculty positions that support clinician-scientists to engage in independently funded scientific research as well as clinical activities.

The objective of the NIH Career Transition Award (K22) is to provide support to outstanding basic or clinical investigators to develop their independent research skills through a two phase program: an initial period involving an intramural appointment at the NIH and a final period of support at an extramural institution. This NINDS K22 is specifically designed to facilitate the transition of NINDS intramural neurologist- and neurosurgeon-scientists to independent, academic faculty positions that support clinician-scientists to engage in independently funded scientific research as well as clinical activities.

Through this Notice of Funding Opportunity (NOFO), entitled "Toward Translation of Nanotechnology Cancer Interventions" (TTNCI), the National Cancer Institute (NCI) encourages applications for advanced pre-clinical research, supporting translation of nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards are designed to mature experimental nanomedicines relying on nanoparticles and nano-devices which demonstrate strong potential to improve cancer treatment effectiveness due to the combination of nanoparticle/nano-device structural design and/or therapeutic/diagnostic cargo which is delivered. TTNCI awards are expected to enable further development of proposed nanotechnology-based interventions to the stage in which they could continue on a developmental path towards the NCI Experimental Therapeutics (NExT) and other NCI translational programs.

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

This Notice of Funding Opportunity (NOFO) encourages grant applications from investigators interested in conducting basic, mechanistic research into the biological/genetic causes of cancer health disparities. These research project grants will support innovative studies designed to investigate biological/genetic bases of cancer health disparities, such as (1) mechanistic studies of biological factors associated with cancer health disparities, including those related to basic research in cancer biology or cancer prevention strategies, (2) the development and testing of new methodologies and models, and (3) secondary data analyses. This NOFO is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can expand available resources and tools, such as biospecimens, patient derived models, and methods that are necessary to conduct basic research in cancer health disparities.

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities. Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication. Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

The purpose of this Notice of Funding Opportunity (NOFO) is to stimulate HIV/AIDS research within the scientific mission areas of the National Institute on Deafness and Other Communications Disorders (NIDCD). Applications should address high priority HIV/AIDS research outlined by the NIH Office of AIDS Research (OAR) (https://www.oar.nih.gov/hiv-policy-and-research/research-priorities) in the areas of hearing, balance, taste, smell, voice, speech, and language.For applications proposing a clinical trial, only low risk clinical trials will be supported.

This notice of funding opportunity (NOFO) will support research towards understanding and mitigating the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids (e.g., fentanyl, carfentanil, nitazenes) and their combinations (fentanyl and xylazine). This NOFO will also support research on the persistent and/or delayed pathophysiological effects after acute exposure to such agents.

Expected Outcome:This call will increase the innovation potential of deep-tech startups in the Widening countries and enable them to better attract private investments and scale up. It will further strengthen the innovation dimension of the widening component and increase the overall competitiveness of these countries.The specific outcome expected of this action is increased business, investor, and technology readiness of high potential deep-tech startups in Widening countries to a level where they will: be successful in applying and attracting the EIC Accelerator funding and/or;manage to secure other private investment and/or;attract successfully national or regional funding as alternative funding sources (e.g. through Seal of Excellence programmes). Scope:This action focuses on early-stage deep-tech startups which 1) have high-impact innovation technology, product, service, or business...

Expected Outcome:Project results are expected to contribute to the following outcomes:For supported doctoral candidatesNew research and transferable skills and competences, leading to improved employability and career prospects within and outside academia;New knowledge allowing the conversion of ideas into products and services, where relevant;Enhanced networking and communication capacities with scientific peers, as well as with the general public that will increase and broaden the research and innovation impact. For participating organisationsImproved quality, relevance and sustainability of doctoral training programmes and supervision arrangements;Enhanced cooperation and transfer of knowledge between sectors and disciplines;Increased integration of training and research activities between participating organisations;Boosted R&I capacity;Increased internationalisation and attractivene...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Demonstrated methodology is used by architects, spatial planners, designers and other relevant actors to identify the extent to which neighbourhoods[1] and communities[1] are intergenerational[1].Demonstrated solutions for intergenerational neighbourhoods and communities are available to public authorities, public/private real estate developers and owners, and stakeholders involved in the green transition[1] of neighbourhoods.The demonstrated solutions make a significant contribution to intergenerational living and measurably advance the green transition in the neighbourhoods (for example in the field of sustainable mobility, accessibility, climate-resilience, water resilience, and/or biodiversity conservation). Scope:Research shows that countries with lower age-related inequalities have...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Construction ecosystem actors[1] are better aware of the negative effects of construction and renovation sites on natural ecosystems as well as on the health and well-being of construction workers and all people living, working or passing through the vicinity.Significant reduction of negative effects of construction and renovation sites on natural ecosystems, health and well-being of construction workers and all people living, working or passing through the vicinity. Scope:Construction and renovation sites can significantly contribute to environmental degradation through noise, air pollution, litter and waste. They also cause other disturbances such as soil compaction, dust emissions, water contamination, or vibration that can negatively impact surrounding natural ecosystems and biodiver...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Local stakeholders adopt long-term stewardship and participate[1] in anticipating and envisioning the long-term future[2] of their existing neighbourhoods[3].Existing neighbourhoods are more resilient and can adapt to changing socioeconomic, cultural, demographic, and climatic conditions, challenges and needs. Scope:The New European Bauhaus (NEB) is redefining the way neighbourhoods across Europe and beyond are presently planned, designed, developed, and revitalised by fostering a new paradigm for sustainable[3], inclusive[3], and beautiful[3] living environments and lifestyles.Neighbourhoods are currently planned for short and medium term, typically with a 5 to 10-year perspective[7], often influenced by insufficient coordination with broader regional and national levels or changing pol...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:The scientific community, public authorities and neighbourhood[1] actors have a better understanding of social issues that influence the green transition[1] in neighbourhoods thanks to novel, transdisciplinary[1] combinations of knowledge and research methods. Robust evidence resulting from novel, transdisciplinary combinations of knowledge and research methods informs decision-making, policymaking, design and planning, and/or public service design for the green transition of neighbourhoods, including their nature-positive[4] transformation. Skills transfer among the scientific community and non-scientific actors involved in planning and implementing the green transition at the neighbourhood level. Scope:Social challenges (e.g. access to affordable housing, energy poverty, access to qual...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Policy makers, local administrations and neighbourhood[1] actors across Europe and beyond have access to evidence-based guidance and recommendations to support public participation in the green transition[1] of neighbourhoods, including their nature-positive[3] transformation.Co-governance[1] approaches aligned with NEB help balance interests, power and knowledge asymmetries and adopt more-than-human[1] approaches at the neighbourhood level; and inform policy, legal, regulatory and institutional frameworks at the national and EU levels. Scope:Public participation in the governance of the green transition of neighbourhoods presents an opportunity to improving inhabitant’s quality of life while addressing climate, biodiversity, and pollution challenges. For instance, co-governance may cont...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Stakeholders involved in the construction[1] and renovation ecosystem adopt innovative solutions for the mass customisation of offsite manufactured modular construction components.Significantly reduced waste and environmental impacts (including air quality, noise and transportation) and enhanced local cultural heritage and/or aesthetics[2] of the built environment[1] compared to using conventional modular construction components. Scope:Solutions to transform the existing built environment[1] in line with the New European Bauhaus (NEB) have typically been at smaller, individual scale so far. The wider uptake and adaptation of such solutions require a manufacturing approach that is efficient, affordable, and accessible while at the same time being adaptable to different local needs and con...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:More optimised construction or renovation processes and improved building performance thanks to hybrid building solutions combining innovative and conventional construction materials, products or techniques.Increased awareness of the construction ecosystem[1] actors of the positive and negative aspects of hybrid building solutions. Scope:The transition to a more sustainable[1] built environment[1] has led to the development of innovative constructions materials, products and techniques supporting the decarbonisation, climate resilience, circularity[4], durability or adaptability of buildings and the built environment, such as bio-based[1] and circular building materials, 3D-printed building elements or the redevelopment and/or adaptation of vernacular and traditional construction materia...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:The use of the innovative solutions reduces the environmental, ecological, economic, social and health negative effects of existing, active railway lines and motorways[1] on demonstrator sites, contributing to their revitalisation.Improved adoption of solutions by the stakeholders such as local authorities, inhabitants, architects, engineers, landscape architects or urban planners. Scope:Active railway lines and motorways are an integral part of the European landscape. However, they can be perceived as sources of disturbances such as pollutants, noise and air pollution, invasive alien plants species vectors, potential hazards, etc. Moreover, railways lines and motorway may negatively impact surrounding neighbourhoods[1] through which they pass, making them unsightly, neglected, unattract...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Community[1] stakeholders co-create[1] and participate[3] in innovative community investment and community ownership models.Community stakeholders benefit from increased local democratic participation, social equity and cohesion, a sense of place and belonging, and local economic development. Scope:Collective community investment and ownership models can empower diverse local community stakeholders to collectively invest in, own, manage, and benefit from local commercial, housing, transitional, or mixed-use assets. By directly engaging community stakeholders, such bottom-up and place-based approaches respond to local community needs and preferences and create local agency and long-term stewardship in the revitalisation of neighbourhoods.Proposals are expected to address all of the follow...

Expected Outcome:Project results are expected to contribute to all of the following outcomes: Near-to-market solutions for the safe integration and use of CCUS technologies in the energy- and carbon-intensive industry;A pipeline of projects that have the potential for commercial scale-up.Deeper understanding of the needs and concerns of diverse social groups involved in or potentially affected by the R&I development of the technology, thereby increasing the potential for beneficial societal uptake and building trust in results and outcomes. Scope:Projects are expected to be the de-risking first step to develop local or regional industrial CCUS clusters, i.e. (multi) source and (multi) sink solutions for the decarbonisation of the hard-to-abate industries of the region. Projects are expected to be the basis and orientation for future full-size projects. To maximise the impact, projects sh...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Enhanced reliability, resilience, controllability and efficiency of electricity distribution grids. Congestion in distribution grids is managed effectively;Distribution system operators (DSO) leverage modern digital solutions and employ improved systems to effectively manage their grids and improve interoperability with TSOs and other DSOs;Vendor-agnostic reference architectures, solutions and tools are developed to help advancing the ADSM design and operation and effectively manage a broad range of grid services. Scope:Projects are expected to address all the following items:Design and test innovative solutions, architectures, technologies and processes for advancing the way the ADSM are designed and operated;Provide ADSM software platforms that improve grid performance, controllability, a...

Expected Outcome:Large PV systems such as utility scale PV are evolving towards higher voltage architecture (>=3kV) with the objective to minimize losses and improve system efficiency at lower costs. The intention is to integrate also storage into such (hybrid) PV systems offering flexibility. It is consequently essential to build a blueprint for the implementation of high voltage large PV systems and the development of Direct Current (DC) networks around strategic end users for high voltage demand (industrial sites, servers, electric vehicle charging stations…). Understanding the factors that influence the performance and economics of these system architectures will help system planners evaluate the potential benefits of such hybrid resources that could support an increasing future industrial electrification. Another crucial challenge to address in ensuring the continued growth of new i...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Enhanced EU cooperation to generate knowledge sharing on data and analytics used for the planning and operation of European grids, and market integration;Better EU coordination with regard to planning and simulation tools to support the development of electricity grids and integration of RES are made available to the research, academia, grid operators, and key actors in the energy value chains;Coordinated processes to generate new and innovative open-source solutions, software modules etc. that are added to the existing and/or new repositories that support the development of grids and integration of high shares of RES;Improved EU-wide cooperation and coordination of actions on developing and utilising innovative data-driven solutions for energy, including AI-powered tools.Support to researc...