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This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities. Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication. Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

Expected Outcome:This call will increase the innovation potential of deep-tech startups in the Widening countries and enable them to better attract private investments and scale up. It will further strengthen the innovation dimension of the widening component and increase the overall competitiveness of these countries.The specific outcome expected of this action is increased business, investor, and technology readiness of high potential deep-tech startups in Widening countries to a level where they will: be successful in applying and attracting the EIC Accelerator funding and/or;manage to secure other private investment and/or;attract successfully national or regional funding as alternative funding sources (e.g. through Seal of Excellence programmes). Scope:This action focuses on early-stage deep-tech startups which 1) have high-impact innovation technology, product, service, or business...

This notice of funding opportunity (NOFO) will support research towards understanding and mitigating the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids (e.g., fentanyl, carfentanil, nitazenes) and their combinations (fentanyl and xylazine). This NOFO will also support research on the persistent and/or delayed pathophysiological effects after acute exposure to such agents.

Expected Outcome:Project results are expected to contribute to the following outcomes:For supported doctoral candidatesNew research and transferable skills and competences, leading to improved employability and career prospects within and outside academia;New knowledge allowing the conversion of ideas into products and services, where relevant;Enhanced networking and communication capacities with scientific peers, as well as with the general public that will increase and broaden the research and innovation impact. For participating organisationsImproved quality, relevance and sustainability of doctoral training programmes and supervision arrangements;Enhanced cooperation and transfer of knowledge between sectors and disciplines;Increased integration of training and research activities between participating organisations;Boosted R&I capacity;Increased internationalisation and attractivene...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Demonstrated methodology is used by architects, spatial planners, designers and other relevant actors to identify the extent to which neighbourhoods[1] and communities[1] are intergenerational[1].Demonstrated solutions for intergenerational neighbourhoods and communities are available to public authorities, public/private real estate developers and owners, and stakeholders involved in the green transition[1] of neighbourhoods.The demonstrated solutions make a significant contribution to intergenerational living and measurably advance the green transition in the neighbourhoods (for example in the field of sustainable mobility, accessibility, climate-resilience, water resilience, and/or biodiversity conservation). Scope:Research shows that countries with lower age-related inequalities have...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Construction ecosystem actors[1] are better aware of the negative effects of construction and renovation sites on natural ecosystems as well as on the health and well-being of construction workers and all people living, working or passing through the vicinity.Significant reduction of negative effects of construction and renovation sites on natural ecosystems, health and well-being of construction workers and all people living, working or passing through the vicinity. Scope:Construction and renovation sites can significantly contribute to environmental degradation through noise, air pollution, litter and waste. They also cause other disturbances such as soil compaction, dust emissions, water contamination, or vibration that can negatively impact surrounding natural ecosystems and biodiver...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Local stakeholders adopt long-term stewardship and participate[1] in anticipating and envisioning the long-term future[2] of their existing neighbourhoods[3].Existing neighbourhoods are more resilient and can adapt to changing socioeconomic, cultural, demographic, and climatic conditions, challenges and needs. Scope:The New European Bauhaus (NEB) is redefining the way neighbourhoods across Europe and beyond are presently planned, designed, developed, and revitalised by fostering a new paradigm for sustainable[3], inclusive[3], and beautiful[3] living environments and lifestyles.Neighbourhoods are currently planned for short and medium term, typically with a 5 to 10-year perspective[7], often influenced by insufficient coordination with broader regional and national levels or changing pol...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Stakeholders involved in the construction[1] and renovation ecosystem adopt innovative solutions for the mass customisation of offsite manufactured modular construction components.Significantly reduced waste and environmental impacts (including air quality, noise and transportation) and enhanced local cultural heritage and/or aesthetics[2] of the built environment[1] compared to using conventional modular construction components. Scope:Solutions to transform the existing built environment[1] in line with the New European Bauhaus (NEB) have typically been at smaller, individual scale so far. The wider uptake and adaptation of such solutions require a manufacturing approach that is efficient, affordable, and accessible while at the same time being adaptable to different local needs and con...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:More optimised construction or renovation processes and improved building performance thanks to hybrid building solutions combining innovative and conventional construction materials, products or techniques.Increased awareness of the construction ecosystem[1] actors of the positive and negative aspects of hybrid building solutions. Scope:The transition to a more sustainable[1] built environment[1] has led to the development of innovative constructions materials, products and techniques supporting the decarbonisation, climate resilience, circularity[4], durability or adaptability of buildings and the built environment, such as bio-based[1] and circular building materials, 3D-printed building elements or the redevelopment and/or adaptation of vernacular and traditional construction materia...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:The use of the innovative solutions reduces the environmental, ecological, economic, social and health negative effects of existing, active railway lines and motorways[1] on demonstrator sites, contributing to their revitalisation.Improved adoption of solutions by the stakeholders such as local authorities, inhabitants, architects, engineers, landscape architects or urban planners. Scope:Active railway lines and motorways are an integral part of the European landscape. However, they can be perceived as sources of disturbances such as pollutants, noise and air pollution, invasive alien plants species vectors, potential hazards, etc. Moreover, railways lines and motorway may negatively impact surrounding neighbourhoods[1] through which they pass, making them unsightly, neglected, unattract...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Policy makers, local administrations and neighbourhood[1] actors across Europe and beyond have access to evidence-based guidance and recommendations to support public participation in the green transition[1] of neighbourhoods, including their nature-positive[3] transformation.Co-governance[1] approaches aligned with NEB help balance interests, power and knowledge asymmetries and adopt more-than-human[1] approaches at the neighbourhood level; and inform policy, legal, regulatory and institutional frameworks at the national and EU levels. Scope:Public participation in the governance of the green transition of neighbourhoods presents an opportunity to improving inhabitant’s quality of life while addressing climate, biodiversity, and pollution challenges. For instance, co-governance may cont...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:Community[1] stakeholders co-create[1] and participate[3] in innovative community investment and community ownership models.Community stakeholders benefit from increased local democratic participation, social equity and cohesion, a sense of place and belonging, and local economic development. Scope:Collective community investment and ownership models can empower diverse local community stakeholders to collectively invest in, own, manage, and benefit from local commercial, housing, transitional, or mixed-use assets. By directly engaging community stakeholders, such bottom-up and place-based approaches respond to local community needs and preferences and create local agency and long-term stewardship in the revitalisation of neighbourhoods.Proposals are expected to address all of the follow...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Enhanced reliability, resilience, controllability and efficiency of electricity distribution grids. Congestion in distribution grids is managed effectively;Distribution system operators (DSO) leverage modern digital solutions and employ improved systems to effectively manage their grids and improve interoperability with TSOs and other DSOs;Vendor-agnostic reference architectures, solutions and tools are developed to help advancing the ADSM design and operation and effectively manage a broad range of grid services. Scope:Projects are expected to address all the following items:Design and test innovative solutions, architectures, technologies and processes for advancing the way the ADSM are designed and operated;Provide ADSM software platforms that improve grid performance, controllability, a...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Improved energy security of the energy system by offering cost-effective and efficient solutions for additional diverse and flexible energy storage capacities.Improve the sustainability and circularity of energy storage systems.Enhanced economic viability of energy storage by utilizing existing infrastructures. Scope:Demonstration of novel or improved technological solutions for cost-efficient, circular and sustainable energy storage, which contribute to grid flexibility and make use of existing obsolete or outdated energy or other infrastructures. Proposals should integrate the synergies between novel or improved energy storage technologies and retrofitting of obsolete or outdated infrastructures, like e.g. old hydropower dams and basins, decommissioned power plants, former industrial faci...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Enhanced EU cooperation to generate knowledge sharing on data and analytics used for the planning and operation of European grids, and market integration;Better EU coordination with regard to planning and simulation tools to support the development of electricity grids and integration of RES are made available to the research, academia, grid operators, and key actors in the energy value chains;Coordinated processes to generate new and innovative open-source solutions, software modules etc. that are added to the existing and/or new repositories that support the development of grids and integration of high shares of RES;Improved EU-wide cooperation and coordination of actions on developing and utilising innovative data-driven solutions for energy, including AI-powered tools.Support to researc...

Expected Outcome:Project results are expected to contribute to all the following expected outcomes:Enhanced reliability, resilience, and efficiency of electricity transmission grids. Grid congestion is managed efficiently;Enhanced observability of grids and improved forecasting of supply, demand, grid capacity availability, and flexibility;Transmission system operators (TSO) leverage modern digital solutions and employ improved systems to effectively manage their grids and improve interoperability with other TSOs;Vendor-agnostic reference architectures, solutions and tools are developed to help advancing the TSO control room design and operation. Scope:Projects are expected to address all the following items:Design and test innovative solutions, technologies and processes for advancing the way the TSO control rooms are designed and operated, increasing observability and entailing enhance...

Expected Outcome:Large PV systems such as utility scale PV are evolving towards higher voltage architecture (>=3kV) with the objective to minimize losses and improve system efficiency at lower costs. The intention is to integrate also storage into such (hybrid) PV systems offering flexibility. It is consequently essential to build a blueprint for the implementation of high voltage large PV systems and the development of Direct Current (DC) networks around strategic end users for high voltage demand (industrial sites, servers, electric vehicle charging stations…). Understanding the factors that influence the performance and economics of these system architectures will help system planners evaluate the potential benefits of such hybrid resources that could support an increasing future industrial electrification. Another crucial challenge to address in ensuring the continued growth of new i...

Expected Outcome:The REPowerEU plan and the EU Solar Energy Strategy introduced targets for the deployment of solar PV amounting to 600 GWac by 2030. Complying with these targets will be crucial for the European Union to reach its climate targets and free itself from import dependency on fossil fuels and the costs this imposes on Europe’s competitiveness in terms of high energy prices. The Solar Strategy also introduces a target, which has been enshrined into the Net-Zero Industry Act, to re-consolidate the European solar manufacturing sector and scale up European manufacturing capacity across the entire value chain to at least 40% of the EU’s annual deployment needs, or 30 GW of annual capacity by 2030. Innovation is particularly important in the solar PV sector, which is characterised by a short technology cycle, where new technologies become mainstream in only a few years. Novel tande...

Expected Outcome:Project results are expected to contribute to all of the following outcomes: Near-to-market solutions for the safe integration and use of CCUS technologies in the energy- and carbon-intensive industry;A pipeline of projects that have the potential for commercial scale-up.Deeper understanding of the needs and concerns of diverse social groups involved in or potentially affected by the R&I development of the technology, thereby increasing the potential for beneficial societal uptake and building trust in results and outcomes. Scope:Projects are expected to be the de-risking first step to develop local or regional industrial CCUS clusters, i.e. (multi) source and (multi) sink solutions for the decarbonisation of the hard-to-abate industries of the region. Projects are expected to be the basis and orientation for future full-size projects. To maximise the impact, projects sh...

Expected Outcome:For a renewables-based electricity system sufficient flexible and also in the long-run fully sustainable hydropower capacity is pivotal.Project results are expected to contribute to all of the following expected outcomes:Enhancing the capacities of the hydropower fleet to contribute with variable renewables base load to a secure and stable electricity system, including by modernising grid integration and hydropower fleet control.Increase technology leadership, competitiveness and technology export potential of European hydropower industry.Address challenges of climate change adaptation for a forward-looking and stable operation of sustainable hydropower for the coming decades. Scope:Demonstration of hydropower technology solutions which allow for efficient and forward-looking refurbishment of existing hydropower plants. Provided solutions must be socioeconomically and en...

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:The scientific community, public authorities and neighbourhood[1] actors have a better understanding of social issues that influence the green transition[1] in neighbourhoods thanks to novel, transdisciplinary[1] combinations of knowledge and research methods. Robust evidence resulting from novel, transdisciplinary combinations of knowledge and research methods informs decision-making, policymaking, design and planning, and/or public service design for the green transition of neighbourhoods, including their nature-positive[4] transformation. Skills transfer among the scientific community and non-scientific actors involved in planning and implementing the green transition at the neighbourhood level. Scope:Social challenges (e.g. access to affordable housing, energy poverty, access to qual...

The purpose of this Notice of Opportunity Announcement (NOFO) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of drug using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of drug abuse and HIV.

The purpose of this notice of funding opportunity (NOFO) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of drug using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of drug abuse and HIV.