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This Notice of Funding Opportunity (NOFO) seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation of neural cells and circuits, to address major challenges and enable transformative understanding of dynamic signaling in the central nervous system. Preliminary feasibility data are not required, and it is expected that the proposed research may be high-risk, but if successful could profoundly change the course of neuroscience research. Applications may propose development of instrumentation hardware and/or devices and associated software, and/or molecular constructs for sensing and manipulating neural activity. Approaches may utilize any modality such as optical, electrical, magnetic, or acoustic recording/manipulation, to target neuronal electrical signals or other forms of neural activity, including intracellular signaling and engagement of non-neuronal cells in circuit function. A companion NOFO (RFA-NS-25-017) is targeted to projects focused on optimization of instrumentation and devices that are later in the development cycle, where iterative optimization and end-user testing is needed. The companion NOFO does not allow projects primarily focused on development or optimization of molecular constructs for recording and manipulating neural activity. Projects of this nature are supported by this NOFO and other BRAIN Initiative announcements including RFA-MH-22-245, RFA-MH-21-175, and RFA-EY-21-001 (or their reissue). For this and the companion NOFO, the aim of the proposed technologies should be t...

The Secretary of the Interior (Secretary), through the Bureau of Indian Affairs (BIA), is soliciting grants from Indian Organizations to establish and operate off-reservation Indian child and family service programs. The intent of the Indian child and family service programs is to provide services for stabilizing Indian families and Tribes, preventing the breakup of Indian families and, in particular, to ensure that the permanent removal of an Indian child from the custody of his/her Indian parents or Indian custodian should be a last resort.

For the addresses for obtaining and submitting an application, please refer to our Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234), and available at https://www.federalregister.gov/documents/2025/08/29/2025- 16571/common-instructions-and-information-for-applicants-todepartment-of-education-discretionary-grantams. Program Purpose: The purpose of the SPDG program is to assist State educational agencies (SEAs) in reforming and improving their systems for personnel preparation and professional development in early intervention, educational, and transition services to improve results for children with disabilities. The U.S. Department of Education (ED) shall award grants, on a competitive basis, to SEAs to carry out the activities described in the State plan submitted under section 653 of the Individuals with Disabilities Education Act (IDEA) (20 U.S.C. 1453). Assistance Listing Number: 84.323A.

The purpose of the CGSA program is to enhance the quality of assessment instruments and assessment systems used by States for measuring the academic achievement and growth of elementary and secondary school students. The FY 2026 competition includes two absolute priorities, three competitive preference priorities, two invitational priorities, selection criteria, and requirements. The absolute priorities are: 1) Developing Innovative Assessment Item Types and Design Approaches and 2) Meaningful Learning Opportunities. The competitive preference priorities are: 1) Improving Assessment Scoring and Score Reporting, 2) Assessing Student Growth, and 3) Comprehensive Academic Assessment Instruments. The invitational priorities are: 1) Assessment and Data Literacy and 2) Comprehensive Assessment Systems.

The purpose of this program, under Assistance Listing Number 10.228, is to promote and strengthen the ability of Alaska Native-serving Institutions and Native Hawaiian-serving Institutions to carry out education, applied research, and related community development programs. NIFA intends this program to address educational needs, as determined by each institution, within a broadly defined area of food, agricultural, natural resources, and human sciences (FANH). 

The purpose of the GusNIP-NI is to fund and evaluate projects intended to increase the purchase of fruits and vegetables by SNAP participants in all 50 States, the District of Columbia, Guam, and U.S. Virgin Islands; and the Nutrition Assistance Program (NAP) Block Grants participants in Puerto Rico, American Samoa, and the Commonwealth of the Northern Marianas Islands by providing incentives at the point of purchase. When the term “SNAP/NAP” is used it is means both the SNAPNAP Block Grants.

Save America"s Treasures grants from the Historic Preservation Fund provide preservation and/or conservation assistance to nationally significant historic properties and collections. For collections, the program supports museums, libraries, archives, and all other collecting institutions in addressing conservation needs of nationally significant collections including physical conservation, curation, care, and collections management. Grants are awarded through a competitive process and require a dollar-for-dollar, non-Federal match, which can be cash or documented in-kind. The grant program is administered by the National Park Service (NPS) in partnership with the National Endowment for the Arts (NEA), the National Endowment for the Humanities (NEH), and the Institute of Museum and Library Services (IMLS).There are separate opportunities for preservation and collections projects. The collections opportunity can be found under opportunity number P25AS00508. The preservation opportunity can be found under opportunity Number P25AS00469.

Save America"s Treasures (SAT) grants from the Historic Preservation Fund provide preservation and/or conservation assistance to nationally significant historic properties and collections. Grants are awarded through a competitive process and require a dollar-for-dollar, non-Federal match, which can be cash or documented in-kind. The grant program is administered by the National Park Service (NPS) in partnership with the National Endowment for the Arts (NEA), the National Endowment for the Humanities (NEH), and the Institute of Museum and Library Services (IMLS). There are separate opportunities for preservation and collections projects. The preservation opportunity can be found under opportunity number P25AS00469. The collections opportunity can be found under opportunity number P25AS00508. FY2025 Public Law 119-4 provides $25.5 million for the SAT Grant Program.

The primary goal of BFRDP, under assistance listing number 10.311, is to help beginning farmers and ranchers in the United States and its territories enter and/or improve their successes in farming, ranching, and management of nonindustrial private forest lands, through support for projects that provide education, outreach, and technical assistance to give beginning farmers and ranchers the knowledge, skills, and tools needed to make informed decisions for their operations and enhance their sustainability. 

The goal of this concept is to increase the impact of the BRAIN Initiative by targeted dissemination and integration of validated BRAIN Initiative tools to investigators at institutions that historically have not been major recipients of NIH support. This will be accomplished by awards to PIs at resource-limited institutions (RLIs) who pair with BRAIN technologists to facilitate training and adoption of BRAIN Initiative technologies in the recipient laboratories. Goals include two-way knowledge transfer between the PI and BRAIN technologist and to increase the participation of PIs at RLIs in BRAIN Initiative relevant research.

The purpose of this funding opportunity is to support research addressing barriers that limit progress toward more effective open- and closed-loop diabetes control systems. This may include research that addresses: 1) innovation of sensing relevant analytes/physiologic signals; 2) novel formulation and delivery of hormones; 3) artificial intelligence (AI)/machine learning (ML)-driven tools/algorithms; and 4) digital twin modeling to augment decision support and automated control systems with the goal of improving glycemic control, reducing burden of care, and enhancing quality of life of people with T1D].This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks

Objective:Expected results:Improvement in the trans-national distribution of recent non-national European films.Increase in the investment in the production, acquisition, promotion, theatrical and online distribution of non-national European films.Develop links between the production and distribution sector thus improving the competitive position of non-national European films.Description of the activities:There are two phases for the funded activities:1. The generation of a potential fund which will be attributed according to the performance of the company on the European market.2. The implementation of the action - the potential fund thus generated by each company must be reinvested in:-minimum guarantees or advances paid for the international sales rights on eligible non-national European films;-the promotion, marketing and advertising on the market of eligible non-national European f...

The National Center for Advancing Translational Sciences (NCATS) invites applications for the Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) Notice of Funding Opportunity (NOFO) to foster investigator-initiated development of highly innovative technologies to address barriers, limitations, or bottlenecks in translational science particularly for therapeutic development. This program will support the early-stage proof of concept, high-risk and potentially high-reward studies for feasibility and exploratory technology development, which can transform or significantly improve the efficiency of therapeutic development to achieve NCATS ultimate goals - more treatments to all people more quickly. The research proposed should be for the development of technology that can break new ground or extend present technology toward new directions or novel applications. With this initiative, we expect to support the development and/or prototyping of new technologies that will lead to improved efficiency in the therapeutic development pipeline.

Through CSP State Entity grants, the Department awards grants on a competitive basis to State entities that, in turn, award subgrants to eligible applicants for the purpose of opening new charter schools and replicating and expanding high-quality charter schools. This program provides financial assistance to State entities to support charter schools that serve elementary and secondary school students in States with a State statute specifically authorizing the establishment of charter schools. Charter schools receiving funds under this program may also serve students in early childhood education programs or post secondary students.

The Secretary of the Interior ("Secretary"), through the Division of Energy and Mineral Development (DEMD), Office of Trust Services, Bureau of Indian Affairs (BIA), is soliciting grant proposals from Federally recognized Tribal entities for the Energy and Mineral Development Program (EMDP) grant. The EMDP grant seeks to identify, evaluate, and assess, energy or mineral resources and related projects on Indian land.Certified Local Governments are encouraged to prioritize projects in support of the celebration of America"s 250th birthday (American250). This may include, but is not limited to, preservation 2 planning, interpretation, public engagement, and rehabilitation projects that recognize and honor the nation"s founding, history, and cultural heritage.Only Indian Tribes and Tribal Energy Development Organizations (TEDOs) are eligible to receive EMDP grants for projects on Indian land, as provided under the Energy Policy Act of 2005, as amended, and codified under sections 3501-3503 of title 25 of the United States Code (25 U.S.C. § 3501-3503). EMDP grants may only fund projects occurring on Indian land as defined in the under 25 U.S.C. § 3501.

As the United States commemorates 250 years of independence through the America250 and Freedom250 initiatives, the U.S. Department of State's U.S. Embassy Praia announces an open competition to celebrate this historic milestone while advancing core U.S. foreign policy priorities in Cabo Verde. This initiative promotes democratic governance, inclusive economic growth, and strengthened bilateral partnerships through interactive programming highlighting American excellence in innovation, education, culture, and democratic institutions.In alignment with the U.S. Strategy for Sub-Saharan Africa, this program seeks proposals from eligible organizations and individuals to engage youth, emerging leaders, educators, entrepreneurs, and broader Cabo Verdean audiences. The America250 and Freedom250 commemorations provide a strategic opportunity to explore enduring principles of freedom, civic responsibility, and democratic values—examining how these principles have shaped American democracy for 250 years and their relevance to contemporary challenges including freedom of expression, economic opportunity, digital access, civic participation, and innovation.Priority areas include technology and innovation, artificial intelligence and digital responsibility, cybersecurity, American culture and history, and youth civic participation. All proposals must include a clear American element, such as collaboration with U.S. experts, institutions, or exchange alumni, or content highlighting U.S. democratic institutions and innovation.

The Gulf of America Division (“GAD”), located in U.S. Environmental Protection Agency (“EPA”) Region 4, is part of the EPA Great Water Body program that collaborates to protect, maintain, and restore the health and productivity of the Gulf of America consistent with the economic well-being of the region. EPA’s actions are designed to support improved water quality; to enhance, restore and/or protect natural habitats; and to improve the region’s ability to withstand storm events. This notice announces the availability of funds and solicits applications to improve water quality and/or habitat through collaboration with America’s farmers. Applications must align with the Administration’s "Powering the Great American Comeback" initiative and align with EPA statutory authorities. Activities must take place in the Gulf of America watershed and/or within the United States contiguous zone in the Gulf of America. This opportunity is targeted to organizations described in Section 2.A. that are committed to supporting American farmers and preventing, reducing, or eliminating nutrient pollution while remaining good stewards of tax dollars.

The U.S. Department of State’s U.S. Mission to NATO announces an open competition to implement a program that strengthens transatlantic security by advancing understanding of NATO’s role in collective defense and defense industrial cooperation. Through the Public Diplomacy Small Grants Program, the Office of the Public Affairs Advisor will support initiatives that connect U.S. and Allied stakeholders, build expertise, and foster collaboration across defense, policy, and innovation. Programs will target policymakers, researchers, industry representatives, and emerging leaders across NATO Allies and partner countries. Activities may include workshops, exchanges, research, and digital engagement focused on defense investment, industrial capacity, and the integration of emerging technologies. Eligible recipients include not-for-profit organizations, academic institutions, and other entities capable of implementing public diplomacy programs with a clear U.S. component. Full Notice of Funding attached.

This program funds projects that improve the safety, efficiency, and reliability of intercity passenger and freight rail.

This Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) Mentored Research Scientist Development Award (K01) helps researchers develop skills in violence prevention research. The goal is to support scientists in becoming independent researchers. Applicants must propose a research project that focuses on at least one of the following NCIPC research priorities related to interpersonal violence and suicide affecting children and youth (birth to age 17). These research priorities include adverse childhood experiences, child abuse and neglect, youth violence, intimate partner violence (including teen dating violence), sexual violence, suicide, and cross-cutting preventions (i.e. examining two or more of these priority topics). For more information, see https://www.cdc.gov/injury-violence-prevention/programs/research-priorities.html. Applicants are encouraged to explore multiple forms of interpersonal violence and/or suicide among children or youth, community factors that increase the risk of interpersonal violence and/or suicide, and the practical relevance of the research for prevention and intervention efforts.

Many valuable and widely available data sets have been generated by multiple Common Fund programs. The purpose of this NOFO is to announce the availability of funding to demonstrate and enhance the utility of selected Common Fund (https://commonfund.nih.gov/) data sets, including generating hypotheses and catalyzing discoveries. Award recipients are asked to provide feedback on the utility of the Common Fund data resources.

The Rural Health and Safety Education Program, under ALN 10.516, seeks to foster quality of life in rural communities by providing the essential knowledge necessary for successful programs of rural development; improving coordination among Federal agencies, other levels of government and institutions, and private organizations in rural areas; and developing and disseminating information about rural conditions. The RHSE program supports quality of life in rural communities across the United States by addressing the relationship between rural prosperity and rural health and safety in the context of food, agriculture, natural resources, and human sciences.  

Program Description: The Jacob K. Javits Gifted and Talented Students Education Program (Javits) supports evidence-based research, demonstration projects, innovative strategies, and similar activities designed to build and enhance the ability of elementary schools and secondary schools nationwide to identify gifted and talented students and meet their special educational needs. A major emphasis of the program is on implementing evidence-based activities that accelerate learning and improve student outcomes. Assistance Listing Number: 84.206A. Applicants are required to follow the 2025 Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions. Note: For new potential grantees unfamiliar with grantmaking at ED, please consult our “Getting Started with Discretionary Grant Applications” webpage.

The AgrAbility program works to increase the likelihood that individuals with disabilities, including veterans, and their families engaged in the agricultural enterprise (AgrAbility customers) will become more successful. The program supports cooperative demonstration projects at state and regional levels and one technical assistance and training national project. The AgrAbility supports American rural communities by: i. Funding cooperative, demonstration State and Regional AgrAbility Projects (SRAPs) between State Cooperative Extension Services based at either 1862 or 1890 Land-grant Institutions and private, nonprofit community-based disability serving organizations to provide on-the-farm agricultural education and assistance to accommodate farmers with disabilities and their families; and ii. Funding a National AgrAbility Project (NAP) at a national private nonprofit disability organization to provide technical assistance, training, information dissemination, and other activities to support community-based, direct service and on-site rehabilitation and assistive technology programs for farmers (including veterans) with disabilities and their families who are engaged in farming or farm-related occupations or, in the case of veterans, who are pursuing new farming opportunities. 

The Employment and Training Administration at the U.S. Department of Labor (DOL) is soliciting application in support of the administration of the Teacher Quality Partnership (TQP) program on behalf of the U.S. Department of Education (ED). The purpose of the TQP program is to improve student achievement; improve the quality of prospective and new teachers by improving teacher preparation and enhancing professional development to hold teacher preparation programs at institutions of higher education (IHEs) accountable for preparing teachers who meet applicable State certification and licensure requirements; and recruit highly qualified individuals into the teaching force. The TQP program also supports the use of Registered Apprenticeships as a high-quality, work-based learning pathway for preparing and credentialing new teachers based on demonstrated skill and merit, particularly in high-need schools and subject areas experiencing teacher shortages.