Opportunities
Search

This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi site clinical trial (Phase III and beyond) application submitted under companion PAR-21-243. The DCC application must be specific to the companion Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website (http://www.nccih.nih.gov). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase III and beyond) to study the effects of natural products (i.e. botanicals, probiotics, and products marketed as dietary supplements) in NCCIH designated areas of high research priority. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Applicants should describe plans for a Clinical Coordinating Center to develop and implement the proposed multi-site clinical trial. The objective of the Clinical Coordinating Center application is to provide the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. Clinical Coordinating Center applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. Clinical Coordinating Center applications submitted under this NOFO will utilize a two-phase, milestone-driven, cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center application, submitted under PAR-24-125, proposing a data analysis and data management plan for the clinical project is required. Both a Clinical Coordinating Center application and a corresponding Data Coordinating Center (DCC) application need to be submitt...

This Notice of Funding Opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi-site clinical trial (Phase Ill and beyond) application submitted underTEMP-26943. The DCC application must be specific to the collaborating Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of the NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of the NCCIH, applicants are encouraged to consult the NCCIH website: (http://www.nccih.nih.gov). Applicants are strongly encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

NOTICE: Amended April 14, 2026. This amendment releases final text for this graduate student research program, which was previously TBD. Neither notices of intent nor Step-1 proposals are requested nor accepted. Proposals are due July 14, 2026. An optional, pre-proposal webinar for all potential proposers will occur May 28 at 1 p.m. Eastern Time, and the Earth Science Division optional office hours via Teams will occur June 23 and 24 at 1 p.m. Eastern Time, see Section 12.7 of the program element PDF on the right side of this NSPIRES page. This synopsis is a generic summary that is posted for each of the many individual "program elements" in NASA’s Research Opportunities in Space and Earth Sciences (ROSES) – 2025 solicitation. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of ROSES at https://solicitation.nasaprs.com/ROSES2025table2 and https://solicitation.nasaprs.com/ROSES2025table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in the Solar System Science program (NNH25ZDA001N-SCUBED) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.2 Solar System Science (.pdf)” to download the text of the call. If one wanted to set i...

Request for Applications Description: The U.S. Integrated Ocean Observing System (IOOS®) is a national and regional partnership working to provide ocean, coastal and Great Lakes observations, data, tools, and forecasts to improve safety, enhance the economy, and protect our environment. To increase observational and technical capabilities we need smart investments to innovate sensors, data management, decision support products, and other technical capabilities that will improve our ability to monitor and forecast environmental conditions with greater efficiency. The primary objective of IOOS’ Ocean Technology Transition Project (OTT) is to reduce the Research to Operations/Commercialization transition period for ocean observing, product development, and data management technologies for the ocean, coastal and Great Lakes. The term ‘Technologies’ includes: ocean, coastal, and Great Lakes sensors, information technology (data management, data visualization), platform enhancement, and technology modernization efforts.This objective is accomplished by investing in the transition of emerging and promising marine and Great Lakes observing technological capabilities from the mid to latter phases of research into operational status. Earlier technical development is supported by programs such as the NOAA Ocean Enterprise Accelerators [https://ioos.noaa.gov/ioos-in-action/accelerators/].The U.S. IOOS Office is seeking to fund projects, subject to the availability of funds, which advance new or existing technology-based solutions that address long standing and emerging coastal observin...

The U.S. Department of State’s U.S. Mission New Zealand announces an open competition to implement a program to advance U.S.-Cook Islands and U.S.-Niue maritime cooperation, economic and cultural ties. The program is intended to support local solutions and build local capacity to:  1.     Increase economic linkages with the United States 2.     Promote long-term economic prosperity through natural resource management 3.     Reduce threats against the United States and the Pacific region. Projects are encouraged to include a plan to build capacity and technical expertise among local communities and organizations. Projects may address one or more of the following areas, but are not strictly limited to the following topics: ·        Increasing economic linkages with the United States through exchange, education, work, and trade promotion programs; ·        Promoting long-term prosperity by incorporating best practices for natural resource management; ·        Advancing U.S.-Cook Islands and U.S.-Niue cooperation to enhance safety, especially in digital media, information technology, emergency preparedness, artificial intelligence, maritime, health, and other related sectors. Projects may propose activities targeted through this solicitation in the following countries: Cook Islands and Niue.

The U.S. Department of State’s Mission New Zealand Public Diplomacy Section (PDS) announces an open competition to implement a program to advance U.S.- New Zealand economic, scientific, and cultural ties. The program is intended to support organizations to build capacity to strengthen or advance the U.S.-New Zealand relationship. Projects may address one or more of the following areas but are not strictly limited to the following topics: ·       Promoting science by reinforcing cooperation in key domains, including (but not limited to) scientific research in Antarctica, space exploration and regulatory frameworks, and critical technology and artificial intelligence. ·       Advancing prosperity by promoting economic growth and innovation with a focus on biotechnology, space technology, and broader innovation sectors.  ·       Strengthening democratic values and ties through programs that celebrate shared democratic principles, cultural connections, and innovative spirit of the peoples of the United States and New Zealand, including but not limited to programming leveraging sports, education, and other areas of connection. This Annual Program Statement (APS) seeks to partner with eligible entities, including not-for-profit organizations, education institutions, individuals, or government institutions, to advance U.S. foreign policy by strengthening the U.S.-New Zealand partnership in science, innovation, and shared values. By promoting collaboration in scientific research, space, critical technology, and disaster management, the APS supports a free and open Indo-Pacific and....

Project Background, Goals, and Objectives Bolivia has one of the largest informal economies in Latin America, with a significant portion of entrepreneurial activity occurring outside formal business structures. Many entrepreneurs operate small-scale businesses in sectors like retail, food services, construction, and personal services without formal registration, limiting their access to credit, legal protections, and growth opportunities. These informal businesses also face barriers to adopting modern business practices and technologies, including U.S.-based financial management tools and digital solutions that could enhance their competitiveness. By bringing businesses into the formal economy, ScaleUp Bolivia will expand the customer base for U.S. products and services, create more reliable supply chain partners for American companies, and open new markets for American technology providers and suppliers. The program will strengthen the rule of law and economic governance, reduce unfair competition in the marketplace, increase municipal tax revenues that support local development, and generate economic growth that benefits both Bolivian communities and U.S. commercial interests. Additionally, formalized businesses become better positioned to engage in international trade and adopt U.S. business standards, creating a foundation for sustained bilateral economic partnership.Project Audience(s): Primary beneficiaries should include:•Informal entrepreneurs currently operating outside the formal economy who are ready to legitimize their businesses.•Micro and small business owners...

The purpose of this document is to advise the public that NOAA/NOS/National Centers for Coastal Ocean Science (NCCOS) Competitive Research Program (NCCOS/CRP) [formerly Center for Sponsored Coastal Ocean Research (CSCOR)/Coastal Ocean Program (COP)] is soliciting proposals to drive practical and cost-effective innovations for harmful algal bloom toxin detection in seafood that promotes seafood safety, food security, and the economic success of U.S. seafood industries and their competitiveness in global markets. For this Announcement, proposals will focus on the development and advancement of innovative, efficient, and effective point-of-use harmful algal bloom toxin detection technologies in support of the Nation’s nutritional, cultural, and economic seafood interests, and to reduce costs to U.S. communities and industries that rely on safe seafood. --- Funding is contingent upon the availability of Federal appropriations. If funding is available for this program, two to five projects are expected to be supported for one to three years in duration, with an approximate annual budget for each project of $100,000-$250,000, not to exceed $750,000 per project. NCCOS/CRP may reject any proposals submitted with an annual budget that is greater than $250,000 for any year. --- An informational webinar on this solicitation will be offered on March 24, 2026 from 2 to 3 p.m. Eastern Time. Information regarding this Announcement, including the webinar and additional background information, is available on the NCCOS Funding Opportunities webpage (https://coastalscience.noaa.gov/about/fun...

The U.S. Department of State’s Embassy Doha announces an open competition to implement a program to advance concrete U.S. economic, technological, and security interests in Qatar. This is not a call for traditional cultural programming. What We Fund: Projects that position U.S. firms and technologies as Qatar's preferred partners; demonstrate how America's open society drives innovation; strengthen U.S.-Qatar security cooperation; and use Freedom250 to showcase American excellence in ways that support strategic objectives. What We Require: Clearly defined target audiences, specific measurable objectives, concrete impact metrics, and strategic alignment with U.S. interests. Four Themes (choose at least one): 1. Strategic Economic and Technology Partnership 2. Open Information, Free Inquiry, and Innovation 3. Sovereignty, Security, and the U.S. as High-Trust Partner 4. American Heritage, Excellence, and Freedom 250 (must connect to contemporary U.S. strengths) The overarching goal of this NOFO is to make America safer, stronger, and more prosperous by focusing public diplomacy resources on initiatives that directly support U.S. national interests while deepening U.S.–Qatar cooperation.

Please note that this program requests optional Notices of Intent, which are due via NSPIRES by May 20, 2026. See the full posting on NSPIRES for details. Amended April 20, 2026. This amendment presents a new program element in ROSES-2025. Notices of Intent (NOIs) are requested by May 20, 2026, and Proposals are due July 21, 2026. Connection information for a Pre-proposal webinar that will occur on June 24, 2026, will be posted under "Other Documents" on the right side of this NSPIRES page. Proposals submitted to this program will be evaluated using dual anonymous peer review, see Section 13. An Open Science and Data Management Plan is not required, see Section 6. Proposers are strongly encouraged to use the Earth Science standard template for the Table of Work Effort, see Section 7. This synopsis is a generic summary that is posted for each of the many individual "program elements" in NASA’s Research Opportunities in Space and Earth Sciences (ROSES) – 2025 solicitation. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of ROSES at https://solicitation.nasaprs.com/ROSES2025table2 and https://solicitation.nasaprs.com/ROSES2025table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in the Solar System Science...

Modification 0002 Annoucement (04/21/26): Extended LOI due date to 4/24/2026 Extended TA1 due date to 5/29/2026 Extended TA2 due date to 6/25/2026 Extended TA3 due date to 7/23/2026 Modification 0001 Announcement (04/15/26): Corrected units in Figure 3; Replaced instances of ‘FOA’ with ‘NOFO’ in Section D. Expected Performance Goals, Application Metrics; Corrected LOI character limit in Section IV.C. This Notice of Funding Opportunity (NOFO) supports critical minerals and materials. Critical minerals and materials (CMM) are the building blocks for technologies foundational to U.S. energy dominance, national security, and industrial competitiveness. To build a secure domestic supply of CMMs, the U.S. Department of Energy (DOE) aims to support collaborative industry partnerships to prototype and pilot innovative processing technologies that are currently only proven at the bench scale to address CMM challenges in high impact areas. The CMM Accelerator program will advance these mid-stage innovations through validation, benchmarking, access to national lab test beds, testing in industry relevant environments, technoeconomic analysis, and life-cycle assessment. The program establishes a pipeline to support technology maturation to ultimately unlock private capital investments. It also will leverage other DOE lab-based activities, such as the Critical Materials Innovation Hub (CMI Hub) and the Minerals to Materials Supply Chain Research Facility (METALLIC). Technologies resulting from the program are expected to have a path to domestic commercialization within 3-7 years. This NO...

The National Oceanic and Atmospheric Administration (NOAA) Coral Reef Conservation Program provides financial assistance through the Ruth D. Gates Coral Reef Conservation Grants - Fishery Management competition for projects to sustainably manage coral reef fisheries, as authorized under the Coral Reef Conservation Act, 16 U.S.C. § 6410. Projects funded through this competition are for activities that: 1) Develop or update sustainable coral reef fisheries management plans; 2) Address science/information gaps that help advance sustainable management of coral reef fisheries stocks; 3) Advance ecosystem-based fisheries management by modernizing analysis of existing data and application of fisheries management tools. Proposals selected for funding through this solicitation will be implemented through one- to three-year grants or cooperative agreements. Approximately $1,000,000 is expected to be available for this competition. The NOAA Coral Reef Conservation Program anticipates that awards will range from $50,000-$200,000. NOAA will not accept proposals requesting less than $50,000. Funds will be administered by the Office of Habitat Conservation in conjunction with the NOAA Coral Reef Conservation Program. Funding may be divided among the U.S. Pacific and Atlantic regions to maintain the geographic balance of the NOAA Coral Reef Conservation Program grant portfolio, as required by the Coral Reef Conservation Act. Please see the National Marine Fisheries Service website on the Grant Application Process. You will need to pay close attention to the submission checks section and th...

Summary: The fiscal year 2026 (FY26) Peer Reviewed Medical Research Program (PRMRP) Discovery Award supports novel, untested, high-risk, high-reward research projects with the potential to provide new insights, paradigms, technologies, or applications and with a potential to generate preliminary data that will lay the foundation for future projects. The application must address a critical problem or question in the field of research and/or patient care in a congressionally directed FY26 PRMRP topic area and one of the FY26 PRMRP portfolio-specific strategic goals.Distinctive Features: Applications must not include preliminary data. The focus of this award mechanism is innovation. Research proposed to this mechanism should be pioneering and revolutionary, and the outcomes generated by the award are expected to generate robust preliminary data that will lay the groundwork for future avenues of scientific investigation or product development.Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $11.165M to fund approximately 29 Discovery Award applications with total cost caps of $385,000 per award. The maximum period of performance is 2 years. It is anticipated that awards made from this FY26 funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awards supported with FY26 funds will be made no later than September 30, 2027.

Summary: The fiscal year 2026 (FY26) Peer Reviewed Medical Research Program (PRMRP) Research Advancement Award supports fundamental research studies that will make an important contribution towards research, patient care, and/or quality of life for a disease or condition related to one of the congressionally directed FY26 PRMRP topic areas and one of the FY26 PRMRP portfolio-specific strategic goals.Distinctive Features: Applications must include preliminary data. The Research Advancement Award supports use-inspired basic research to further or validate preliminary findings for short- and long-term impact. Proposed research projects may range from hypothesis testing to expansion of mature data.Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $19.6M to fund approximately 14 Research Advancement Award applications with total cost caps of $1.4M per award. The maximum period of performance is 4 years. It is anticipated that awards made from this FY26 funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awards supported with FY26 funds will be made no later than September 30, 2027.

The U.S. Embassy Kuala Lumpur Public Diplomacy Section seeks proposals that advance American leadership, prosperity, and security interests in Malaysia. This program supports initiatives that promote U.S. technological innovation and economic competitiveness, showcase American excellence in sports and education, strengthen ties with exchange program alumni, and position the United States as Malaysia's most trusted international partner.   Priority areas include: advancing U.S. leadership in artificial intelligence and emerging technologies; leveraging major sporting events to demonstrate American excellence; engaging alumni networks to amplify U.S. influence; and promoting American English language education and pathways to U.S. higher education institutions. Programs should demonstrate clear alignment with U.S. national interests, measurable outcomes, and sustainable impact beyond the grant period. Successful proposals will engage influential Malaysian stakeholders, promote American standards, and contribute to making America more prosperous and secure.

This program element does not have a proposal due date. Proposals may be submitted at any time, pending certain eligibility timing issues related to resubmissions and duplicate proposal avoidance, see the program element text and appropriate overview appendix (e.g., B.1 or C.1). The date shown of 8/1/2026 is the last day that proposals may be submitted subject to the ROSES-25 rules and the current GCAM. The ROSES-26 version of this program element is planned to overlap with this ROSES-25 version by a few weeks, allowing continuous submission of proposals across ROSES years. NOTICE: Amended, January 22, 2026. Table C.2-1: Submission and Review Dates in Section 3.1 has been updated and a new final row with a cutoff date of August 1, 2026, has been added. Also, the expected budget and number of new awards in Section 4 have been increased. New text is in bold and deleted text is struck through. NOTICE: Corrected September 9, 2025. NASEM Astrobiology Strategy citation was corrected to 2019 (see Section 1.1.3), reference to the anonymized Table of Work Effort was added to Section 3.2, and HEC request is not included in anonymized proposal (see Section 3.5). New text is in bold and deleted text is struck through. NOTICE: ROSES-25 Amendment 7 makes the following changes to C.1 the Planetary Research Overview: It establishes funding threshold and submission requirements for substantial instrument or equipment requests (Section 3.11), removes the estimated page limit for pilot studies (Section 3.4) and clarifies text on use of spacecraft mission data (Section 3.5). New text is in bol...

The National Human Genome Research Institute (NHGRI) seeks to broaden the types of knowledge, skills, expertise, experience, and perspectives brought to bear in research addressing the ethical, legal and social implications (ELSI) of advances in human genetics or genomics. This Notice of Funding Opportunity (NOFO) solicits UM1 applications from domestic organizations located in the United States and its territories that received less than $30 million per year in total NIH funding for the past three fiscal years. These organizations are underrepresented among those receiving NHGRI funding for ELSI research. The Building Partnerships and Broadening Perspectives to Advance Ethical, Legal, and Social Implications (ELSI) Research (BPAER) Program will support: 1) transdisciplinary ELSI research addressing timely, complex, and understudied topics, 2) the establishment of research teams that include representatives from relevant communities who are affected by and have an interest in the proposed research, 3) research capacity building to develop, conduct and sustain ELSI research, and 4) workforce development opportunities for early career scholars, research team members, and other research project staff. Transdisciplinary ELSI research projects require involvement from two or more fields of knowledge and use of multiple research approaches. Relevant communities must be actively and meaningfully involved on ELSI research teams across all phases of proposed research projects. Research capacity building plans must be informed by a needs assessment. Given the complex structure, a str...

Summary: The fiscal year 2026 (FY26) Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development Award, a product-driven award mechanism, intends to support the translation of promising preclinical findings into products for clinical applications, including prevention, detection, diagnosis, treatment, or quality of life, for a disease or condition related to one of the congressionally directed FY26 PRMRP topic areas and one of the FY26 PRMRP strategic goals. Products can be tangible items, such as drugs or devices, or can be knowledge products, such as clinical decision-making tools or practice guidelines. Products in development should address or have dual purpose potential for the health care needs of military Service Members, Veterans and their Families.Distinctive Features: For the PRMRP Technology/Therapeutic Development Award, the program expects the research proposed will take an already established proof-of-concept or prototype through the final stages of preclinical development. The PRMRP also expects that the research outcome will be a regulatory filing or translation of findings into clinical practice, as applicable.Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $67.2M to fund approximately 12 Technology/Therapeutic Development Award applications with total cost caps of $5.6M per award. The maximum period of performance is 4 years. It is anticipated that awards made from this FY26 funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awar...

Summary: The fiscal year 2026 (FY26) Peer Reviewed Medical Research Program (PRMRP) Lifestyle and Applied Health Research Award supports clinical research and/or clinical trials using a combination of scientific disciplines including occupational science, psychology, psychometrics, biostatistics and epidemiology, surveillance, implementation science, and population health. Applications must address and provide a solution to one of the congressionally directed FY26 PRMRP topic areas and one of the FY26 PRMRP strategic goals.Distinctive Features: This funding opportunity requires patient advocate participation. The patient advocate will be a person living with, or a family member or caretaker of someone with, a disease or condition addressed in one of the congressionally directed FY26 PRMRP topic areas. Animal research is not allowed.Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $16.8M to fund approximately four Lifestyle and Applied Health Research Award applications with total cost caps of $4.2M per award. The maximum period of performance is 4 years. It is anticipated that awards made from this FY26 funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awards supported with FY26 funds will be made no later than September 30, 2027.

Summary: The fiscal year 2026 (FY26) Peer Reviewed Medical Research Program (PRMRP) Impact Award supports applied research, defined as use-inspired and practice-oriented science that brings together outcomes from basic research, and insights from the real-world environment, to foster clinical applicability. The Impact Award intends to translate the fundamental understanding of underlying mechanisms toward solutions that have the potential for major near-term impact for patients and clear alignment to one of the congressionally directed FY26 PRMRP topic areas and one of the FY26 PRMRP portfolio-specific strategic goals.Distinctive Features: This funding mechanism allows for multiple Principal Investigators (PIs). Only the initiating PI’s organization will submit a pre-application, but all PIs’ organizations will need to submit full applications. The partnering PI’s application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.Funding Details: The Congressionally Directed Medical Research Programs (CDMRP) expects to allot roughly $32.0M to fund approximately 10 Impact Award applications with total cost caps of $2.8M for the Single PI Option, or $3.6M for the Partnering PI Option. The maximum period of performance is 4 years. It is anticipated that awards made from this FY26 funding opportunity will be funded with FY26 funds, which will expire for use on September 30, 2032. Awar...

NOTICE: Amended May 8, 2026. This amendment releases final text for this program element, which was previously TBD. Notices of Intent are requested by June 25, 2026, and proposals are due August 6, 2026. This synopsis is a generic summary that is posted for each of the many individual "program elements" in NASA’s Research Opportunities in Space and Earth Sciences (ROSES) – 2025 solicitation. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of ROSES at https://solicitation.nasaprs.com/ROSES2025table2 and https://solicitation.nasaprs.com/ROSES2025table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in the Solar System Science program (NNH25ZDA001N-SCUBED) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.2 Solar System Science (.pdf)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Research Program Overview (.pdf)” from that same page. While the letters and numbers are different for each element within ROSES (A.10, B.3, etc.) the b...

PLEASE NOTE: this program has MANDATORY Notices of Intent, which are due via NSPIRES by June 25, 2026. See the full posting on NSPIRES for details. NOTICE: Amended May 8, 2026. This amendment releases final text for this program element, which was previously TBD. Mandatory Notices of Intent are due June 25, 2026, and proposals are due August 6, 2026. This synopsis is a generic summary that is posted for each of the many individual "program elements" in NASA’s Research Opportunities in Space and Earth Sciences (ROSES) – 2025 solicitation. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of ROSES at https://solicitation.nasaprs.com/ROSES2025table2 and https://solicitation.nasaprs.com/ROSES2025table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in the Solar System Science program (NNH25ZDA001N-SCUBED) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.2 Solar System Science (.pdf)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Res...

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry to the Development stage, to advance a single development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Alternatively, projects can enter at the Development stage and progress in a shorter period to IND enabling toxicology studies and phase I clinical testing. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

This program element does not have a proposal due date. Proposals may be submitted at any time, pending certain eligibility timing issues related to resubmissions and duplicate proposal avoidance, see the program element text and appropriate overview appendix (e.g., B.1 or C.1). The date shown of 8/31/2026 is the last day that proposals may be submitted subject to the ROSES-25 rules and the current GCAM. The ROSES-26 version of this program element is planned to overlap with this ROSES-25 version by a few weeks, allowing continuous submission of proposals across ROSES years. NOTICE: Amended, January 26, 2026. Sections 1 and 1.1 have been updated to encourage non-governmental organizations new to NASA to partner with NASA centers, and a requirement was added to Section 4 to plan for operation beyond the award period. New text is in bold and deleted text is struck through. NOTICE: Amended, January 22, 2026. The last date for submission of proposals (in Section 7) has been updated to reflect that ROSES-25 will be open until August 2026. Proposals may be submitted at any time until August 31, 2026. New text is in bold and deleted text is struck through. NOTICE: Amended September 22, 2025. This amendment announces that those proposing to Earth Science (ROSES Appendix A) to use the NASA Center for Climate Simulation high-end computing facility must include $0.09/SBU in their budget per the instructions provided in Section 7.3 of ROSES-25 A.1 Earth Science Research Overview. This applies to all open and future program elements in Appendix A (Earth Science) as of 09/22/2025. This....