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The purpose of this Program Announcement (PAR) is to enable clinical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of biomarker measurements within the clinical population of interest to establish the positive and negative predictive values of the candidate biomarker consistent with FDA guidelines. This PAR assumes that 1) a candidate biomarker has already been identified, 2) detection method technology has already been developed and analytically validated, and 3) the research and/or clinical need and potential context of use has been identified.

The purpose of this notice of funding opportunity (NOFO) is to support rigorous analytical validation of method(s) used for measuring biomarkers for neurological and neuromuscular disorders for use in clinical trials or clinical practice. Applicants must justify the unmet need for the biomarker(s) and measurement methods and specify one or two context(s) of use for the biomarker(s). Activities supported include optimizing and evaluating the accuracy, precision, reportable range, and analytical sensitivity and specificity of the detection method across multiple sites and operators and establishing reference intervals and quality control procedures. Multi-site applications are expected but not required.

The purpose of this proposed Notice of Funding Announcement (NOFO) is to support development of biomarkers or clinical outcomes derived from digital health technology (DHT) for use in clinical trials for remote monitoring as primary or secondary endpoints. To improve clinical impact, increase statistical feasibility, and promote standardization, applicants will be expected to develop and test the digitally derived assessments in populations from at least three different diseases or conditions. Partnerships with non-profit patient advocacy organizations will be required.

The Naval Air Warfare Center Aircraft Division (NAWCAD) is interested in receiving white papers for Research and Development projects which offer potential for advancement and improvement of NAWCAD operations. See attachment, FY25 NAWCAD Office-Wide N00421-25-S-0001, for further details.

The close date above is NOT the date for the Step-2 proposal due date as the Step-2 due date for this program will be announced at least 60 days before the Step-2 proposal due date. The Step-1 proposal due date is 01/21/2026. Step-2 proposals cannot be submitted if a Step-1 proposal was not submitted. NOTICE: Amended April 23, 2026. This amendment announces the Step-2 due date for this program element which was previously TBD. The Step-2 due date is June 22, 2026. Step-2 proposals can only be submitted by those who submitted a Step-1 proposal and were invited to submit a Step-2. NOTICE: Amended November 25, 2025. This amendment releases final text for this program element, which was previously TBD. Step-1 proposals are due January 21, 2026. The Step-2 due date will be announced at least 60 days before the Step-2 proposal due date, see Section 5.1. This synopsis is a generic summary that is posted for each of the many individual "program elements" in NASA’s Research Opportunities in Space and Earth Sciences (ROSES) – 2025 solicitation. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of ROSES at https://solicitation.nasaprs.com/ROSES2025table2 and https://solicitation.nasaprs.com/ROSES2025table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposal...

The Precision Measurement Grant Program (PMGP) is seeking applications from eligible applicants for activities to conduct research work in the field of fundamental measurement, testing the basic laws of physics, and/or the determination of fundamental constants, with emphasis on pressing problems or emerging opportunities.

This program funds projects that improve the safety, efficiency, and reliability of intercity passenger and freight rail.

This notice of funding opportunity (NOFO) supports research, implementation science, and public health evaluations to inform best practices for preventing and responding to infectious disease threats in Kenya, while strengthening local research capacity.The award recipient will conduct research, implementation science, and public health evaluations through the Kenya Medical Research Institute (KEMRI) and focus on four required priority areas:Influenza and other respiratory pathogens: Activities include surveilling high-risk groups; monitoring for human and avian influenza and other pathogens; and evaluating efficacy and use of vaccines and other treatments. Outcomes include increasing understanding of disease burden and improving vaccination strategies.Vaccine-preventable diseases: Research will assess disease burden, vaccine effectiveness, and sociocultural factors influencing immunization. Outcomes include increasing vaccine uptake and strengthening immunization systems.Drug-resistant infections: Activities include monitoring antimicrobial resistance (AMR) trends, applying novel diagnostics, and identifying drivers of resistance. Outcomes include improving mitigation strategies and global AMR preparedness.Global and emerging health threats: Research will address malaria, HIV, tuberculosis, schistosomiasis, and emerging infections. Outcomes include improving understanding of disease dynamics, intervention effectiveness, and cross-border risks.The recipient will also conduct research coordination and administration activities to manage and oversee U.S. government–funded pub...

Per the McGovern-Dole program’s authorizing legislation, this funding opportunity is intended to improve food security, reduce the incidence of hunger, and improve literacy and primary education, particularly with respect to girls, through the procurement of U.S. agricultural commodities, plus the provision of financial and technical assistance. All McGovern-Dole projects provide school feeding through a combination of predominantly U.S.-provided and some locally and regionally procured commodities and address the two strategic program objectives 1) Improved Literacy of School-Aged Children, and 2) Increased Use of Health, Nutrition and Dietary Practices. McGovern-Dole projects may also provide some context-specific complementary activities that support these program objectives, including support for maternal, infant, and child nutrition.   In addition, McGovern-Dole projects need to represent America First objectives, including a strong focus on providing U.S. agricultural commodities purchased from American Farmers; clear oversight and monitoring of activities to reduce fraud, waste, and abuse; and realistic strategies to graduate project activities and have a sustainable lasting impact after USDA McGovern-Dole support ends.    When applying, reference the country’s specific identification number as listed in the NOFO and below: USDA-FAS-10.608-0700-26-(511) Bolivia USDA-FAS-10.608-0700-26-(442) Cambodia USDA-FAS-10.608-0700-26-(518) Ecuador USDA-FAS-10.608-0700-26-(675) Guinea USDA-FAS-10.608-0700-26-(522) Honduras USDA-FAS-10.608-0700-26-(669) Liberia USDA-FAS-10.608-07...

This Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) Mentored Research Scientist Development Award (K01) helps researchers develop skills in violence prevention research. The goal is to support scientists in becoming independent researchers. Applicants must propose a research project that focuses on at least one of the following NCIPC research priorities related to interpersonal violence and suicide affecting children and youth (birth to age 17). These research priorities include adverse childhood experiences, child abuse and neglect, youth violence, intimate partner violence (including teen dating violence), sexual violence, suicide, and cross-cutting preventions (i.e. examining two or more of these priority topics). For more information, see https://www.cdc.gov/injury-violence-prevention/programs/research-priorities.html. Applicants are encouraged to explore multiple forms of interpersonal violence and/or suicide among children or youth, community factors that increase the risk of interpersonal violence and/or suicide, and the practical relevance of the research for prevention and intervention efforts.

Executive Summary The U.S. Embassy and Consulates in Brazil, through the Public Diplomacy Section, announce an open competition to implement the U.S. Speaker and Specialist Program in Brazil. This initiative aims to strengthen connections between Brazil and the United States by promoting knowledge exchange, professional collaboration, and shared learning.  The program will bring American specialists to engage with Brazilian institutions and professionals from the public, private, and academic sectors. Activities will focus on U.S. priority areas such as energy, innovation, freedom of expression, public safety, technology, and commercial development, encouraging dialogue and the exchange of practical expertise.  Programming may include lectures, workshops, seminars, and training activities designed to share knowledge, build skills, and support collaboration. These engagements aim to foster meaningful connections, support informed decision-making, and create opportunities for Americans and Brazilian partners.  Subject to the availability of funds, the U.S. Embassy and Consulates in Brazil expect to issue one award of up to $250,000. Applicants should demonstrate the capacity to implement nationwide programming and deliver clear, results-oriented activities.  Project Background, Goals, and Objectives Brazil and the United States have a long history of strong economic ties, innovation, and connections between people and institutions. As one of the largest economies in the world, Brazil plays an important role in areas such as technology, energy, and global trade.   This program...

This program supports Tribes, Tribal organizations, and Urban Indian organizations in implementing produce prescription models that increase access to nutritious and community relevant foods and promote whole-person health and well-being.

The U.S. Mission to the European Union’s commemoration of America’s 250th birthday aims to showcase America’s rich history and honor U.S.-EU contributions to global peace, security, and prosperity. Proposed projects should celebrate U.S. history and innovation among EU audiences and advance relations and economic growth between the United States and the EU. Examples of priority issues and sectors are trade, technological innovation, energy, critical minerals and defense. Now through the end of the year, chosen grantees will work with influential EU civil society, government, private sector, business, and industry leaders to showcase Freedom 250-themed success stories or build people-to people ties with EU institutions to advance or drive growth in priority areas.  Through these activities, grantees may develop and highlight stories, policies, research, and opportunities to support U.S. and joint U.S.-EU initiatives and policies related to but not limited to trade, technological innovation, AI, energy, critical minerals, security and defense, or other critical fields that have made the United States and Europe stronger, safer, and more prosperous.

The U.S. Department of Transportation’s (USDOT) Federal Aviation Administration (FAA) is accepting applications for the fiscal year (FY) 2026 FAA Aircraft Pilots Workforce Development Grant Program of which 20 percent of the total amount funded will be used to carry out the Willa Brown Aviation Education Program. The purpose of the Program is to attract future aircraft pilots or unmanned aircraft systems operators to the aviation industry throughout the United States and U.S. territories.

The U.S. Department of Transportation’s (USDOT) Federal Aviation Administration (FAA) is accepting applications for the fiscal year (FY) 2026 FAA Aviation Maintenance Technical Workers Workforce Development Grant Program of which 20 percent of the total amount funded will be used to carry out the Willa Brown Aviation Education Program. The purpose of the program is to expand the Aviation Maintenance Technical Workers workforce and support activities to facilitate the transition to careers in aviation maintenance throughout the United States and U.S. territories.

The AFG Program provides financial assistance directly to eligible fire departments, nonaffiliated emergency medical service (EMS) organizations, and State Fire Training Academies (SFTAs) to equip and train emergency personnel to recognized standards, outfit responders with compliant personal protective equipment, provide funding to retrofit or modify facilities to protect personnel from known health hazards, acquire emergency response vehicles, design and implement health, wellness and resiliency programs that prepare responders for incident response, enhance operational efficiencies, foster interoperability, and support community resilience. 

The Department of Homeland Security (DHS) Federal Emergency Management Agency’s (FEMA) Grant Programs Directorate implements and administers the Staffing for Adequate Fire and Emergency Response (SAFER) Grants. SAFER grants provide financial assistance to help fire departments increase frontline firefighters. SAFER offers grants to support activities in two activities: 1. Hiring of Firefighters 2. Recruitment and Retention of Volunteer Firefighters The authority for SAFER is derived from Section 34 of the Federal Fire Prevention and Control Act of 1974 (Pub. L. No. 93-498, as amended) (15 U.S.C. § 2229a).

The Department of Homeland Security (DHS) Federal Emergency Management Agency's (FEMA) Grants Programs Directorate is responsible for the implementation and administration of the Fire Prevention and Safety (FP&S) Grant Program. The purpose of the FP&S Program is to enhance the safety of the public and firefighters with respect to fire and fire-related hazards. The FP&S Program offers grants to support activities in two categories: (1) activities designed to reach high-risk target groups and mitigate incidences of death and injuries caused by fire and fire-related hazards ("Fire Prevention and Safety Activity") and (2) research and development activities aimed at improving firefighter safety ("Firefighter Safety Research and Development Activity"). The program guidance document provides potential applicants with the details of the requirements, processing, and evaluation of an application for financial assistance for both of these activity areas.  

The Office of National Drug Control Policy (ONDCP), Executive Office of the President, is seeking applications to provide continued support of anti-doping activities to educate athletes on the dangers of drug use and eliminate doping in amateur athletic competitions recognized by the United States Olympic & Paralympic Committee.

This Unemployment Insurance Program Letter (UIPL) announces the availability of funding to pay for the ongoing costs of administering the Coronavirus Aid, Relief, and Economic Security (CARES) Act Federal Pandemic Unemployment Compensation (FPUC) program. Questions regarding this Unemployment Insurance Program Letter (UIPL) may be emailed to Chanta Ferrell (ferrell.chanta@dol.gov).

This Unemployment Insurance Program Letter (UIPL) announces the availability of funding to pay for the ongoing costs of administering the Coronavirus Aid, Relief, and Economic Security (CARES) Act Pandemic Emergency Unemployment Compensation (PEUC) program. Questions regarding this Unemployment Insurance Program Letter (UIPL) may be emailed to Chanta Ferrell (ferrell.chanta@dol.gov).

This Unemployment Insurance Program Letter (UIPL) announces the availability of funding to pay for the ongoing costs of administering the Coronavirus Aid, Relief, and Economic Security (CARES) Act Mixed Earners Unemployment Compensation (MEUC) program. Questions regarding this Unemployment Insurance Program Letter (UIPL) may be emailed to Chanta Ferrell (ferrell.chanta@dol.gov).

The Award Ceiling for Year 1 is 0 (none). CDC anticipates an Approximate Total Fiscal Year Funding amount of $3,000,000 for Year 1, subject to the availability of funds.The purpose of this NOFO is to reduce TB-related morbidity and mortality in India, the Philippines, and Vietnam by strengthening:• TB case finding, including linked activities such as screening, testing, and diagnostic evaluation.• TB prevention, including TB preventive treatment (TPT).• TB treatment, including linkage and improved treatment regimens, as appropriate.• Surveillance, through adopting, evaluating, and expanding innovative approaches.Activities implemented will focus on:• Expanding and improving diagnosis of TB infection and TB disease, including early and asymptomatic TB as well as drug-resistant or multidrug-resistant TB. This will be done by using and evaluating innovative screening and diagnostic methods and scaling up evidence-based approaches. • Improving TPT outcomes for all individuals at high risk of developing TB disease and improving TB treatment outcomes of individuals with TB disease, including those with drug-resistant or multidrug-resistant TB. This will be done by using new, shorter, and better-tolerated treatment regimens.• Strengthening TB surveillance for data-driven decision making, program planning, and public health action.Asia carries the highest burden of TB and drug-resistant or multidrug-resistant TB globally. This NOFO will focus on activities in India, the Philippines, and Vietnam because they are three of the top four countries contributing to the TB burden in the U....

MGFSP assists agricultural agencies or departments in eligible states and territories to increase the quantity and quality of locally grown food in food insecure communities through small-scale gardening, herding, and livestock operations by competitively distributing subawards to eligible entities.USDA promotes climate-resilient landscapes and rural economic systems, including tools to support agriculture, forests, grazing lands, and rural communities. AMS encourages applicants to consider including goals and activities related to reducing and stabilizing the levels of heat-trapping greenhouse gases in the atmosphere or adapting to the already occurring climate change in their project"s design and implementation.

To support the efforts of States, Tribal governments, and research institutions to promote the domestic maple syrup industry through the following activities: promotion of research and education related to maple syrup production, promotion of natural resource sustainability in the maple syrup industry, market promotion for maple syrup and maple-sap products, Encouragement of owners and operators of privately held land containing species of trees in the genus Acer: to initiate or expand maple-sugaring activities on the land; or to voluntarily make the land available, including by lease or other means, for access by the public for maple-sugaring activities.