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TheBiophotonicsprogram is part of the Engineering Biology and Health cluster, which also includes: 1) theBiosensingprogram; 2) theCellular and Biochemical Engineeringprogram; 3) theDisability and Rehabilitation Engineeringprogram; and 4) theEngineering of Biomedical Systemsprogram. The goal of theBiophotonicsprogram is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology. Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals. Research topics in this program include: Imaging in the second near infrared window:Research that advances medical applications of biophotonics in the second near-infrared window (NIR-II: 1,000-1,700 nm) in which biological tissues are transparent up to several centimeters in depth, making this spectral window ideal for deep tissue imaging. Macromolecule markers: Innovative methods for labeling of macromolecules. Novel compositions of matter. Methods of fabrication of multicolor probes that could be used for marking and detection of specific pathological cells.Pushing the envelope of optical sensing to the limits of detection, r...

The Manufacturing Systems Integration (MSI) Program supports fundamental research addressing the opportunities and challenges that digital technologies present for the next industrial revolution, with particular emphasis on the digital integration of design and manufacturing within the larger life cycle ecosystem. Manufacturing Systems Integration proposals should address underlying principles and advances that are generalizable for globally competitive and world leading industries. Connectivity, automation, and secure collaboration are examples of areas that are integral to digital environments capable of supporting the innovation, realization and sustainment of manufactured products and systems in the value creation process. Fundamental generalizable research for manufacturing systems integration might include, for example: Digital representation, protocols, and/or processes for integration and collaboration in manufacturing systems (machines and/or humans) Intelligent self-organizing production systems Ease of use, interoperability and seamless integration of technologies, machines, and humans Service-oriented architectures and systems Data sets that are compatible and usable across platforms Reliable and secure communications within and across the manufacturing value chain Integration of distributed manufacturing systems across time and space, including incorporating both legacy and leading-edge equipment and technologies Methods for assessing the impact and value of externalities throughout the life cycle within the digital environment Interdisciplinary, convergent pro...

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PLEASE FIND THE NOFO IN THE 'DOCUMENTS' SECTION OF THIS POST This opportunity has been updated as of May 11, 2026 Program Overview: EDA has authority to provide grants to meet the full range of communities’ and regions’ economic development needs from planning and technical assistance to construction of infrastructure. These grants are made through a series of Notices of Funding Opportunity (NOFOs) that can be found on EDA’s website at https://www.eda.gov/funding/funding-opportunities and are designed to support the economic development activities most useful to a community based on its needs and circumstances. EDA funds community or regionally generated ideas and assists communities to advance to the next level of economic development. This NOFO sets out EDA’s application submission and review procedures for two of EDA’s core economic development programs authorized under the Public Works and Economic Development Act of 1965, as amended (42 U.S.C. § 3121 et seq.) (PWEDA): (1) Public Works and Economic Development Facilities (Public Works) and (2) Economic Adjustment Assistance (EAA). EDA supports bottom-up strategies that build on regional assets to spur economic growth and resiliency. EDA encourages its grantees throughout the country to develop initiatives that present new ideas and creative approaches to advance economic prosperity in distressed communities. Through this NOFO EDA intends to advance general economic development in accordance with EDA’s investment priorities, which can be found on EDA's website here: Investment Priorities | U.S. Economic Development Admi...

TheEnvironmental Sustainability program is part of theEnvironmental Engineering and Sustainabilitycluster together with 1) theEnvironmental Engineeringprogram and 2) theNanoscale Interactionsprogram. The goal of theEnvironmental Sustainabilityprogram is to promote sustainable engineered systems that support human well-being and that are also compatible with sustaining natural (environmental) systems. These systems provide ecological services vital for human survival. Research efforts supported by the program typically consider long time horizons and may incorporate contributions from the social sciences and ethics. The program supports engineering research that seeks to balance society's need to provide ecological protection and maintain stable economic conditions. There are five principal general research areas that are supported. Circular Bioeconomy Engineering:This area includes research that enables sustainable societal use of food, energy, water, nitrogen, phosphorus, and materials, with the reduction and eventual elimination of fossil fuel combustion that lacks carbon capture. The program encourages research that helps build the raw material basis for the functioning of society principally on biomass, drawing heavily on sustainable agriculture and forestry. Additionally, material flows must reduce or preferably eliminate waste, with an emphasis on closed-loop or “circular” processing. Industrial ecology:Topics of interest include advancements in modeling such as life cycle assessment, materials flow analysis, net energy analysis, input/output economic models, and nove...

TheElectrochemical Systemsprogram is part of the Chemical Process Systems cluster, which also includes: 1) theCatalysisprogram; 2) theInterfacial Engineeringprogram; and 3) theProcess Systems, Reaction Engineering, and Molecular Thermodynamicsprogram. The goal of theElectrochemical Systemsprogram is to support fundamental engineering science research that will enable innovative processes involving electrochemistry or photochemistry for the sustainable production of electricity, fuels, chemicals, and other specialty and commodity products. Processes utilizing electrochemistry or photochemistry for sustainable energy and chemical production must be scalable, environmentally benign, reduce greenhouse gas production, and utilize renewable resources. Research projects that stress fundamental understanding of phenomena that directly impact key barriers to improved system or component-level performance (for example, energy efficiency, product yield, process intensification) are encouraged. Processes for energy storage should address fundamental research barriers for renewable electricity storage applications, for transport propulsion, or for other applications that could have impact towards climate change mitigation. For projects concerning energy storage materials, proposals should involve testable hypotheses that involve device or component performance characteristics that are tied to fundamental understanding of transport, kinetics, or thermodynamics. Advanced chemistries beyond lithium-ion are encouraged. Proposed research on processes utilizing electrochemistry or photochemis...

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The Energy, Power, Control, andNetworks (EPCN) Program supports innovative research in modeling, optimization, learning, adaptation, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation, as well as risk management in the presence of uncertainty, sub-system failures, and stochastic disturbances. EPCN also invests in novel machine learning algorithms and analysis, adaptive dynamic programming, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN’s goal is to encourage research on emerging technologies and applications including energy, transportation, robotics, and biomedical devices & systems. EPCN also emphasizes electric power systems, including generation, transmission, storage, and integration of renewable energy sources into the grid; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory & economic structures and with consumer behavior. Areas managed by Program Directors (please contact Program Directors listed in the EPCN staff directory for areas of interest): Control Systems Distributed Control and Optimization Networked Multi-Agent Systems Stochastic, Hybrid, Nonlinear Systems Dynamic Data-Enabled Learning, Decision and Control Cyber-Physical Control Systems Applications (Biomedical, Transportation, Robotics) Energy and Power Systems Solar, Wind, and Storage Devices Integration with the Grid Monitoring, Protection and Resilient Operation of Grid Power Gr...

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The Economics program supports research designed to improve the understanding of the processes and institutions of the U.S. economy and of the world system of which it is a part. This program also strengthens both empirical and theoretical economic analysis as well as the methods for rigorous research on economic behavior. It supports research in almost every area of economics, including econometrics, economic history, environmental economics, finance, industrial organization, international economics, labor economics, macroeconomics, mathematical economics, and public finance. The Economics program welcomes proposals for individual or multi-investigator research projects, doctoral dissertation improvement awards, conferences, symposia, experimental research, data collection and dissemination, computer equipment and other instrumentation, and research experience for undergraduates. The program places a high priority on interdisciplinary research. Investigators are encouraged to submit proposals of joint interest to the Economics Program and other NSF programs and NSF initiative areas. The program places a high priority on broadening participation and encourages proposals from groups and regions that traditionally have not participated fully in science, mathematics, and engineering. The program also funds conferences and interdisciplinary research that strengthens links among economics and the other social and behavioral sciences as well as mathematics and statistics. The Doctoral Dissertation Research Improvement Grants (DDRIG) funding opportunity is designed to improve the....

Synopsis TheCellular and Biochemical Engineering(CBE)program is part of theEngineering Biology and Healthcluster, which also includes: 1) theBiophotonicsprogram; 2) theBiosensingprogram; 3) theDisability and Rehabilitation Engineeringprogram; and 4) theEngineering of Biomedical Systemsprogram. TheCellular and Biochemical Engineeringprogram supports fundamental engineering research that advances understanding of cellular andbiomolecular processes. CBE-funded research may lead to the development of enabling technology for advanced biomanufacturing of therapeutic cells, biochemicals, and biopharmaceuticals, and for otherbiotechnology industrie. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches. Fundamental to many CBE research projects is the understanding of how biomolecules, subcellular systems, cells, and cell populations interact, and how those interactions lead to changes in structure, function, and behavior. A quantitative treatment of problems related to biological processes is considered vital to successful research projects in the CBE program. Major areas of interest for the program include: Metabolic engineering and synthetic biology for biomanufacturing, The design of synthetic metabolic components and synthetic cells, Microbiome structure, function, maintenance, and design, Protein and enzyme engineering, and Design of integrated chemoenzymatic systems. The CBE program also encourages proposals that effectively integrate knowledge and practices from different d...

The Facility and Instrumentation Request Process (FIRP) solicitation describes the mechanism by which the research community can propose projects that require access to instrumentation and facilities sponsored by the Facilities for Atmospheric Research and Education (FARE) Program in the Division of Atmospheric and Geospace Sciences (AGS).  FARE provides funding to a variety of organizations to make specialized instrumentation and facilities available to the atmospheric science research community through the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF) programs. FIRP allows for parallel evaluation of intellectual merit and broader impacts along with the feasibility of the proposed project. All proposals to AGS that require the use of FARE-sponsored assets must be submitted through this solicitation.  The FIRP solicitation offers three proposal submission tracks based on the type and purpose of the request:   Track 1 - Education and Outreach. Track 2 - Single Facility Request. Track 3 - Field Campaigns.    Preference for funding will be given to proposals submitted to programs in the Division of Atmospheric and Geospace Sciences (AGS) in the Geosciences Directorate (GEO). If you are planning to submit a proposal to a program outside AGS, including NSF-wide or Directorate-wide solicitations, please contact the FARE program director, Shree Mishra at fare@nsf.gov to discuss the timelines, review process, and budget request for the use of FARE assets. 

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The Catalysis program is part of the Chemical Process Systems cluster, which also includes: 1) the Electrochemical Systems program; 2) the Interfacial Engineering program; and 3) the Process Systems, Reaction Engineering, and Molecular Thermodynamics program. The goals of the Catalysis program are to increase fundamental understanding in catalytic engineering science and to advance the development of catalysts and catalytic reactions that are beneficial to society. Research should focus on critical challenges and opportunities in both new and proven catalysis technologies. Areas of emphasis may include novel catalyst compositions, structures, operating environment, data science tools, theory, and modeling – preferably in various combinations as dictated by the specific reaction and related knowledge and technology gaps. Target applications include fuels, specialty and bulk chemicals, environmental catalysis, biomass conversion to fuels and chemicals, greenhouse gas mitigation, recycling of waste materials, generation of solar hydrogen, as well as efficient routes to energy utilization. Heterogeneous catalysis represents the main thrust of the program. Proposals related to both gas-solid and liquid-solid heterogeneous catalysis are welcome, as are proposals that incorporate concepts from homogeneous catalysis. Recent research trends have highlighted the need for evaluation of catalyst performance and properties under working conditions, especially as supported by advanced in situ and in operando characterization methods. Catalyst synthesizability and stability present additi...

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TheEngineering of Biomedical Systemsprogram is part of the Engineering Biology and Health cluster, which also includes: 1) theBiophotonicsprogram; 2) theBiosensingprogram; 3) theCellular and Biochemical Engineeringprogram; and 4) theDisability and Rehabilitation Engineeringprogram. The goal of theEngineering of Biomedical Systems(EBMS) program is to provide opportunities for fundamental and transformative research projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term. Projects are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. Projects must include objectives that advance both engineering and biomedical sciences. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. TheEBMS programsupports fundamental and transformative research in the following areas of biomedical engineering: Developmentof validated models (living or computational) of healthy and pathological tissues and organ systems that can support improved fundamental understanding of these systems or that could be applied in the future for development and testing of medical interventions; Designand validation of systems that integrate living and non-living c...

TheProcess Systems, Reaction Engineering, and Molecular Thermodynamicsprogram is part of the Chemical Process Systems cluster, which also includes: 1) theCatalysisprogram; 2) theElectrochemical Systemsprogram; and 3) theInterfacial Engineeringprogram. The goal of theProcess Systems, Reaction Engineering, and Molecular Thermodynamicsprogram is to advance fundamental engineering research on the rates and mechanisms of chemical reactions, systems engineering, and molecular thermodynamics as they relate to the design and optimization of chemical reactors and the production of specialized materials that have important impacts on society. The program supports the development of advanced optimization and control algorithms for chemical processes, molecular and multi-scale modeling of complex chemical systems, fundamental studies on molecular thermodynamics, and the integration of these methods and concepts into the design of novel chemical products and manufacturing processes. This program supports sustainable chemical manufacturing research on the development of energy-efficientchemical processes and environmentally-friendly chemical products through concurrent chemical product/process design methods.Sustainability is also enhanced by research that promotes the electrification of the chemical process industries over current thermally-activated processes. Proposals should focus on: Chemical reaction engineering: This area encompasses the interaction of transport phenomena and kinetics in reactive systems and the use of this knowledge in the design of chemical reactors.Research are...