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Scope:Due to the changing overall geopolitical context, Member States, EDF associated countries and their land forces need to improve their indirect fire and rocket artillery capabilities in particular, as many have been relying on non-European systems that are already approaching the end of their operational life.Against this background, this topic aims to develop multiple rocket launcher solutions capable of countering the latest threats by increasing the range and precision of indirect fire, maximising interoperability and optimising the cost-effectiveness of operations in a high-intensity and GNSS-contested battle scenario.This topic contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of defence technologies. Targeted types of activities: Studies and design, not excluding upstream and downstream activities eligible for development action...

Scope:The increasing complexity of military operations requires more advanced electronic warfare (EW) systems capable of dealing with multiple threats and operating in electromagnetic congested scenarios. Current solutions are partially effective and require the complex integration of different sensors and frequency bands. As a result, there is a growing need for automated EW systems that can rapidly identify and respond to threats, especially given the limited availability of qualified personnel.To meet this challenge, this topic aims to further develop and integrate technologies to develop a more robust, cognitive and operational EW system. Cognitive EW systems that use AI and machine learning can detect, learn and interact with the environment, accelerating the development and implementation of next-generation EW threat detection, suppression and neutralisation technologies. These sys...

Scope:The objective of this topic is to follow up and complement previous activities in the field of smart technologies for next generation fighter systems. It aims to explore future architectures and develop key technologies, including with proofs of concept, demonstrations and prototypes, for the next generation of military integrated modular avionics for use on a variety of military aerial platforms, both manned and unmanned aircraft, in the context of a defence air cloud.This topic contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of defence technologies. Targeted types of activities: Integrating knowledge, studies, design and system prototyping, not excluding upstream and downstream activities eligible for development actions.Indicative budget: EUR 25 000 000 for this topic under the EDF-2026-DA call.Indicative number of proposals to...

Scope:Taking into consideration the ongoing activities in this area funded by the EU, EU Member States and EDF associated countries, the general objective of this topic is to support the developments necessary for the integration and qualification of Public Regulated Service (PRS) receivers into existing military operational platforms as well as the enhancement of navigation warfare (NAVWAR) capabilities. In particular, this topic will focus on the development of Galileo PRS receiver technology and the NAVWAR information management system, taking into account the need to also support guided munitions and missiles in operational environments.Beyond defence technologies, this topic also contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of deep and digital technologies.Targeted types of activities: Design, system prototyping, testing and qual...

Scope:The aim of this topic is to follow up and complement previous activities in the field of the next generation self-protection systems in order to increase the survivability of fixed wing and rotary wing, combat or non-combat aircraft in hostile environments.This topic is aimed at modular integration with both fixed and rotary wing aircraft, providing protection against direct and indirect threats based on open architecture and international standards, while protecting sensitive data and ensuring compatibility with other platforms. Key features include automatic coordination of countermeasures, threat detection and classification, and the ability to operate in complex environments. For indirect threats, the system should gather intelligence, disrupt enemy tracking and enable collaborative protection with other platforms.This topic contributes to the STEP objectives as defined in the...

Scope:This topic aims to follow up and complement previous activities in the field of high- performance energy systems, with a particular focus on unexplored technologies such as hydrogen (conversion, storage and logistics). New use cases for stationary military applications will therefore be identified and defined, while innovative building blocks and functional modules will be developed and evaluated. The demonstrators’ power and energy targets and other key performance indicators, including life cycle considerations, are expected to be improved, while the operability and connectivity to the energy grid systems of operational bases will be improved.In addition, this topic aims to advance the creation, revision or consolidation of military standards for products and processes for energy generation, distribution and storage.Beyond defence technologies, this topic also contributes to the...

Scope:This topic aims to improve the protection of seabed infrastructure through a comprehensive system, including unmanned assets, advanced sensors, underwater observation, detection, acquisition and communication systems, and integrated command and control. This initiative focuses on the development and validation of such a system for future operations, integrated with maritime command centres for coordinated responses. The approach combines operational levels and innovative technologies to effectively mitigate risk and ensure continuity of operations.Beyond defence technologies, this topic also contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of deep and digital technologies. Targeted types of activities: Studies and design, not excluding upstream activities eligible for research actions.Indicative budget: EUR 30 000 000 for this topic...

Scope:This topic aims to develop a prototype of a semi-autonomous remote management system, integrated with adaptive hardware that continuously learns and improves its ability to identify and dispose of potential objects. The primary objective is to detect and dispose of ammunition waste and residues from military training areas and battlefields. This will significantly reduce the risk factor associated with human involvement, ultimately contributing to a cleaner environment and in line with the ‘green military’ concept.The performance of the system to be developed is expected to improve over time, allowing it to expand its capabilities and cover larger areas.Beyond defence technologies, this topic also contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of clean and resource-efficient technologies.Targeted types of activities: Studies, desi...

Scope:In order to increase situational awareness and operational superiority, improved detection, tracking and identification capabilities over large areas with increased range and minimum latency are required. High-frequency (HF) over-the-horizon (OTH) systems therefore need to be improved, while an EU concept for a cognitive and scalable network of HF OTH sensors could be further explored.The objective of this topic is to follow up and complement previous activities in the field of OTH, in particular the development of technologies for an EU OTH radar network concept providing deep cooperation and data sharing for strategic surveillance. In this context, both HF surface (active, cooperative and non-cooperative passive) and skywave radar technologies should be explored and integrated for their respective advantages in terms of area covered at long ranges and as a gap filler in an agile...

Scope:Reducing administrative barriers remains a challenge for the rapid movement of armed forces across the borders of EU Member States and EDF associated countries, especially in a constantly deteriorating geopolitical environment. The digitisation of the military mobility permit and clearance landscape is therefore crucial for rapid and efficient deployments.Against this background, this topic aims to follow up and complement activities in this area with the objective of developing a resilient system, including with a mobile application, capable of operating under adverse conditions when not all system nodes are available. This will require the implementation of advanced encryption methods to protect sensitive and urgent information exchanges, as well as embedded tracking and monitoring capabilities.This topic contributes to the STEP objectives as defined in the STEP Regulation in the...

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Breakthrough Award mechanism supports promising research with high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. Applications must address the challenge in a way that can lead to a breakthrough and have major impact. The FY26 Breakthrough Award mechanism contains four different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level specifies a distinct research scope. This program announcement discusses the Breakthrough Award Level 4.Distinctive Features:·        Clinical trials are required.·        The research team must include two or more breast cancer consumer advocates.·        This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Initiating and Partnering PI) applications by the deadline may result in administrative withdrawal.

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Transformative Breast Cancer Consortium Award supports collaborations and ideas that will transform the lives of individuals with, and/or at risk for, breast cancer and will significantly accelerate progress toward ending breast cancer. Applications must propose a synergistic, highly integrated, multidisciplinary and multi-institutional consortium of leading scientists, clinicians and breast cancer consumer advocates that will address a major problem in a way that a single investigator or group could not accomplish. The consortium’s collaborative efforts must make a transformative impact in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. If the application addresses a different fundamental issue, the application must couple it with at least one of the overarching challenges.Distinctive Features: This funding mechanism allows for up to five Principal Investigators (PIs) which includes the Consortium Director and three or four Project Team PIs. Applications must include at least one breast cancer consumer advocate per project team. Only the Consortium Director will submit a pre-application, but all PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Consortium Director and Project Team PIs) applications by the full application deadline may result in administrative withdrawal.

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Breakthrough Award mechanism supports promising research with high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. Applications must address the challenge in a way that can lead to a breakthrough and have major impact. The FY26 Breakthrough Award mechanism contains four different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level specifies a distinct research scope. This program announcement discusses the Breakthrough Award Level 3.Distinctive Features:·        For this funding mechanism, small-scale clinical trials are allowed but not required. Applications proposing projects with a clinical trial should be submitted under the Clinical Trial option.·        The research team must include two or more breast cancer consumer advocates.·        This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Initiating and Partnering PI) applications by the deadline may result in administrative withdrawal.

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in amyotrophic lateral sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients.Distinctive Features: To meet the intent of the funding opportunity, applications may address clinical biomarkers and/or clinical outcomes. This may include the identification, development, and/or validation of promising biomarkers for ALS, which may include, but are not limited to susceptibility/risk, diagnostic, monitoring/disease progression, prognostic, predictive, response, or safety biomarkers. Clinical Outcomes projects may focus on the identification, development, and/or validation of clinician-, observer-, or patient-reported, and/or performance outcome measures for ALS. Projects may include the optimization of current outcome measures already in use.Applications may utilize digital health measures, including wearable devices, smart-phone sensors, video or voice recordings, imaging studies, or other devices which record disease-relevant physiological data and/or outcomes.Community Collaboration is an important element of the FY26 ALSRP COBA. Applicants will be expected to articulate how the proposed research question or study design was informed by theALS lived experience community.

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Idea Award (TIA) supports new, innovative, high-risk, high-gain ideas aimed at amyotrophic lateral sclerosis (ALS) drug or therapy discovery. The studies supported by this award mechanism are expected to be hypothesis-driven and generate preliminary data for future avenues of therapeutic investigation.Distinctive Features: Potential impact and innovation are important features of the TIA. Applications may demonstrate the ability to achieve interpretable results in the absence of preliminary data supporting the hypothesis. While the inclusion of preliminary data is not prohibited, the strength of the application should rely on the approach.

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award (PCTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of amyotrophic lateral sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.Applications must address one of the following focus areas:·        Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.·        Clinical Care: Improving aspects of clinical care and symptom management for ALS.Distinctive Features: Funding from this award mechanism must support a clinical trial. The clinical trial should begin no later than 12 months after the award date or 18 months for U.S. Food and Drug Administration (FDA)-regulated studies.Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.All pre-applications and applications are required to incorporate community collaboration, as described in Section 3.2.2, to optimize research impact.Applications must include a detailed Regulatory Strategy plan that outlines the approach for obtaining regulatory approvals, if required, specifically for the funded portion of the study. In addition, applications must provide a separate Transition Plan that describes how the outcomes of t...

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited amyotrophic lateral sclerosis (ALS) experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints and pathophysiology.Applications supported by this award must begin with lead compounds in hand and must already demonstrate proof-of-concept efficacy data in at least one appropriate preclinical model system of ALS, including whole-animal and cellular model systems.Distinctive Features: Mechanism-specific, predictive/cohort-selective, target engagement and pharmacodynamic biomarker development, in parallel to the main therapeutic effort, is a critical component of the FY26 ALSRP Therapeutic Development Award. If appropriate mechanism-specific biomarkers are already available or currently in development, how the existing biomarkers will improve trial design, patient selection, and efficiency or interpretation of the proposed ALS therapeutic approach must be apparent in the application. Development of biomarkers for the purposes of diagnosis, prognosis, or measurement of general disease progression without consideration of the therapeutic development process will not be supported.Therapeutic candidates which have...

Water Resource Research Act (WRRA) coordination award to support efforts toward water resources research.

This is a NOFO for a Single Source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is announcing its intent to issue a single source cooperative agreement award to Beckman Research Institute/City of Hope for the currently funded Integrated Islet Distribution Program (IIDP) to renew the program and maintain support for its continuing mission to provide the scientific community with important islet resources for diabetes research. The IIDP facilitates the distribution of human islets to biomedical researchers by establishing partnerships with qualified islet isolation facilities to prepare and distribute human islets. Human islets remain an essential resource for diabetes research to advance our understanding of human islet cell biology, and to promote the development of new therapies for the prevention and treatment of diabetes.This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.

The U.S. Fish and Wildlife Service (Service) Coastal Program provides technical and financial assistance to partners to support projects that protect and restore fish and wildlife habitats on public and private lands in priority coastal ecosystems. This support is provided through cooperative agreements with conservation partners and landowners, including state and Tribal agencies. Coastal Program staff work with partners, stakeholders, and other Service programs in important areas for conservation. They implement regional strategic plans that identify priority species and habitats for conservation in these focus areas.Applicants seeking technical or financial assistance from the Coastal Program are required to contact a local Program office BEFORE developing or submitting an application. You can find this information in the current strategic plan at this link or by contacting your local Coastal Program office at https://www.fws.gov/program/coastal/contact-us.Projects are developed collaboratively by partners and Service field staff. All Coastal Program projects must align with the missions of the U.S. Department of the Interior, the U.S. Fish and Wildlife Service, and the Coastal Program. They are also based on sound biological principles and the best available science.

The purpose of this notice of funding opportunity (NOFO) is to establish a Center that trains researchers in formal product development for new substance use disorder (SUD) pharmacotherapeutics and to advance the best concepts through initial experiments via technical and financial support.

This Notice of Funding Opportunity (NOFO) invites a single cooperative agreement application for the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D). The purpose of CaRe-T1D is to support innovative, discovery and mechanistic research through the study of human cardiovascular (CV) tissue. This research seeks to better understand cardiovascular disease (CVD) in type 1 diabetes, highlight differences compared to type 2 diabetes, and ultimately guide the development of therapies to treat this major cause of morbidity and mortality for individuals with type 1 diabetes. To achieve these goals, the Resource Center will expand the CaRe-T1D biorepository of human CV tissue, further develop the data commons for data sharing and for artificial intelligence (AI) tools, coordinate the research activities of the investigative teams in the CaRe-T1D consortium, and make CaRe-T1D resources accessible to the broader research community. This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standar...

Summary: The fiscal year 2026 (FY26) Rare Cancers Research Program (RCRP) Concept Award (CA) supports highly innovative, untested, potentially groundbreaking novel concepts in rare cancers. Applications must describe how the new idea will be innovative and present as a novel course of investigation in the field of rare cancers.Distinctive Features:Preliminary data are not required.Due to the blinded nature of the review process, identifying or making references to the Principal Investigator (PI), collaborator(s), or their organization(s) in the proposal Project Narrative, Supporting Documentations, Impact Statement, Justification Statement, and Statement of Work (SOW) is prohibited and will result in administrative rejection of the application.

Objective:The objective of this call for proposals is to enhance the accessibility to and collection of jurisprudence related to asylum and expand the EUAA Case Law Database.

Expected Outcome:This action will support and accelerate the development and adoption of European and international standards for quantum technologies, enhancing interoperability quality/reliability assurance, and trust in quantum systems. It will strengthen Europe's leadership in the global quantum standardisation landscape and ensure that European industrial and research priorities are well represented and integrated into emerging standards.Expected outcomes include:Delivery of concrete, EU-relevant pre-normative standards and technical specifications across quantum computing, communication, and sensing.Substantial contribution of European stakeholders, notably SMEs and start-ups in international standardisation bodies (e.g., ISO/IEC, ITU-T, ETSI), with alignment to EU industrial strategies.Promotion of cross-sectoral interoperability through standardised interfaces, control protocols,...