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This Notice of Funding Opportunity (NOFO) invites applications from clinical centers to participate in a consortium to test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. Such intervention strategies should support the promotion of healthy growth and development; adequate nutritional status/intake, healthy eating and physical activity behaviors; mental health and well-being (e.g., body image, self-esteem, mood, etc.), and quality of life and be feasible to implement in clinical care settings. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs. Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation. The clinical centers may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscripts. This NOFO uses a cooperative agreement mechanism (U01) and runs in parallel with a companion NOFO (RFA-DK-27-136).

This Notice of Funding Opportunity (NOFO) invites applications for a Research Coordinating Center (RCC) to participate in a consortium of clinical centers that will test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. Such intervention strategies should support the promotion of healthy growth and development; adequate nutritional status/intake, healthy eating and physical activity behaviors; mental health and well-being (e.g., body image, self-esteem, mood, etc.), and quality of life and be feasible to implement in clinical care settings. Priority areas include testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs. Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation. The clinical centers may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscriptsThe RCC will lead, manage, and harmonize efforts for the Consortium including 1) providing management and administrative support; 2) providing leadership and expertise on statistical design a...

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the design, development, and preliminary validation of robust frameworks for the application of multimodal-artificial intelligence (AI) models for clinical use. Frameworks developed through these awards would populate a "playbook", defined as a collection of actionable guidelines, standardized protocols, and/or standard operating procedures (SOPs) for reliable and effective development and deployment of multimodal AI tools. It is expected that the frameworks delineated in this playbook will directly address PRIMED-AI objectives and needs, while also remaining flexible enough to enable sufficient extensibility and interoperability for use across a broad spectrum of multimodal biomedical AI applications, both internal and external to the PRIMED-AI Program.

Buyer: Αρχή Αντιμετώπισης Εξαρτήσεων Κύπρου | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-09

Buyer: gemeente Sittard-Geleen | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-09

Buyer: Consorci de Salut i d’Atenció Social de Catalunya | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-09

Buyer: Consorci de Salut i d’Atenció Social de Catalunya | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-09

Buyer: Gemeente Heerde | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-09

Buyer: Trafikverket Myndighet | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-09

Buyer: Burgergemeinde Biel | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-09

Buyer: GRAD ZAGREB | Notice type: cn-desg | Procedure: open | Contract: services | Deadline: 2026-10-09

Buyer: Kraftwerke Oberhasli AG | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-09

Buyer: Kraftwerke Oberhasli AG | Notice type: cn-standard | Procedure: open | Contract: works | Deadline: 2026-10-09

Buyer: Gerencia del Consorcio Maspalomas Gran Canaria | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2026-10-09

Buyer: Syndicat Martiniquais de Traitement et de Valorisation des Déchets | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2026-10-10

The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial interventions can be optimally delivered, monitored, and sustained over time to enhance effectiveness and generalizability. The NOFO will support studies designed to enhance the rigor of RAPID clinical trial design, which will ultimately increase the interpretability of the data and the generalizability of the results.

Buyer: Pôle Achats DSP | Notice type: cn-standard | Procedure: oth-mult | Contract: services | Deadline: 2026-10-12

Buyer: St. Samenwerkende Vrijescholen Zuid-Holland | Notice type: pin-rtl | Procedure: restricted | Contract: services | Deadline: 2026-10-12

Buyer: Politie | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-12

Buyer: Coöperatieve Vereniging Midwaste Milieu U.A. | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-12

Buyer: Gemeente Lansingerland | Notice type: pin-rtl | Procedure: open | Contract: services | Deadline: 2026-10-12

Buyer: Faaborg Museum | Notice type: cn-standard | Procedure: oth-single | Contract: services | Deadline: 2026-10-12

Buyer: Communauté de Communes des 7 Vallées | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-12

Buyer: Ministère de la Défense | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2026-10-12

Buyer: LYCEE MARITIME ET AQUACOLE DE LA ROCHELLE | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2026-10-12