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This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, participant recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination. The application should also describe its approaches to increase community engagement from conceptual design of the intervention through implementation and sus...

This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies.Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO for a collaborating Data Coordinating Center (PAR-27-013). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The application should also describe its approaches to increasing community engagement from conceptual design of the intervention through implementation and sustainability and close...

Buyer: Sénat | Notice type: cn-standard | Procedure: oth-mult | Contract: services | Deadline: 2028-11-03

Buyer: Hlavné mesto Slovenskej republiky Bratislava | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2028-11-03

Buyer: Københavns Kommune - Teknik- og Miljøforvaltningen | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2028-11-03

Buyer: Københavns Kommune - Teknik- og Miljøforvaltningen | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2028-11-03

Buyer: DAK-Gesundheit | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2028-11-05

Buyer: DAK-Gesundheit | Notice type: cn-standard | Procedure: open | Contract: supplies | Deadline: 2028-11-05

Buyer: REGION HALLAND | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2028-11-05

Buyer: Moravskoslezský kraj | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2028-11-05

Buyer: Region Halland | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2028-11-05

The purpose of this Notice of Funding Opportunity (NOFO) is tofurther elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART).This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit basic research applications to investigate the pathological mechanisms of skin injuries caused by toxic Chemicals of Concern (CoC) identified as public health threats by the United States Government. This NOFO supports the goal of the trans-NIH Chemical Countermeasures Research Program (CCRP) and is intended to spur the discovery and early development of broad-spectrum medical countermeasures (MCMs) to advance the nation's medical and public health preparedness for, response to, and recovery from high consequence chemical disasters and emergencies.

Buyer: COPE Foundation | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2028-11-06

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that invites applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered. The purpose of this NOFO is to solicit current or recently completed NHLBI K01, K08, K23, and K25 awardees for small grant support to expand their current research objectives or to branch out to a new study emerging from their K award research. This NOFO is intended to facilitate the transition to research independence for these NHLBI K awardees. Current NHLBI K01, K08, K23, and K25 awardees may apply for this R03 support starting in the third year of their K award Project Period. Recently completed NHLBI K01, K08, K23, and K25 award recipients are eligible to apply or resubmit A1 applications if the earliest potential R03 award start date is within two years of the end of their K award Project Period.The R03 grant mechanism supports research projects that can be completed within two years and with limited resources. These projects are expected to generate preliminary data to bolster a subsequent R01-equivalent application. Eligible projects include, but are not limited to, pilot or feasibility studies; proof of concept studies; secondary analysis of existing data; small, self-contained research projects; development of new research methodologies or technologies, or creation of novel experimental model systems.Applicants are requi...

Buyer: AB „Kelių priežiūra“ (PV) | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2028-11-08

Buyer: Communauté d'Agglomération Lisieux Normandie | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2028-11-14

Buyer: Département de la Seine-Maritime | Notice type: cn-standard | Procedure: restricted | Contract: services | Deadline: 2028-11-14

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit UG3/UH3 phased, cooperative agreement research applications to evaluate, implement, and/or test population-based interventions to policies, programs, and/or practices for promoting integration of services, systems, and/or values by leveraging cross-sector partnerships in communities. Such interventions must address social and chronic disease common risk factors and/or barriers driving oral disease burden in communities. Projects funded through this funding opportunity and a separately funded Community Engagement Evaluation and Data Coordination hub (CEED) will form a Community-Based Participatory Research (CBPR) consortium: Advancing Data and Practice Transformation (ADAPT), which will receive consultative services from the NIH Community Engagement Alliance Consultative Resource (CEACR) and join in the Science Collaborative for Health and Artificial Intelligence Reduction of Errors (SCHARE) platform for the overarching goal of promoting data use and transformational community engagement to optimize oral health for all people across the lifespan.

Buyer: ВТОРА СПЕЦИАЛИЗИРАНА АКУШЕРО-ГИНЕКОЛОГИЧНА БОЛНИЦА ЗА АКТИВНО ЛЕЧЕНИЕ-ШЕЙНОВО ЕАД | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2028-11-19

Buyer: Sdis 35 | Notice type: cn-standard | Procedure: restricted | Contract: supplies | Deadline: 2028-11-21

Buyer: BwFuhrparkService GmbH | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2028-11-21

Buyer: BARCELONA DE SERVEIS MUNICIPALS, S.A. | Notice type: cn-standard | Procedure: open | Contract: services | Deadline: 2028-11-22

The National Cancer Institute's (NCI) Metastasis Research Network (MetNet) is a collection of U54 Research Centers that support using systems-level approaches to understand pressing questions in metastasis. The overall goal of the MetNet is to advance our understanding of metastasis as a whole body, systems-level problem to develop a comprehensive and cohesive picture of the processes involved. Through this Notice of Funding Opportunity (NOFO), the NCI invites applications for MetNet Research Projects. These Research Projects should be defined as discrete entities that use systems-level approaches to address gaps and opportunities in metastasis research to integrate into the MetNet and complement ongoing research across the Network.

  REQUEST FOR EXPRESSION OF INTEREST     Country:  MOZAMBIQUE Project:  Mphanda Nkuwa Hydroelectric Project Agreement: Preparation Advance No. -V522-MZ. Assignment Title: Individual Consultancy Services to Provision Hydrologist Specialist Project Advisor for providing Project Advisory to undertaking the review of the hydrological studies of the planned Mphanda Nkuwa Hydropower Project.   Reference: MZ-GMNK-442364-CS-INDV       The Government of Mozambique (GoM) hereinafter referred to as “the Borrower” have received Advance funds from International Development Association (IDA) towards the costs of the Mphanda Nkuwa Hydroelectric Project, Preparation Phase. The funds have been channeled through the Mphanda Nkuwa Hydroelectric Project Office (GMNK) as the Project Implementation Agency, and GMNK intends to apply part of the proceeds for Consulting Services for providing Project Advisory for undertaking the review of the hydrological studies of the planned Mphanda Nkuwa Hydropower Project.     The GMNK now invites eligible Individual Consultant (“Consultants”) to express their interest in providing the Services. Interested Individual Consultants should provide information demonstratin...