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MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, subcellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk. This solicitation calls for proposals in research areas supported by the four MCB core clusters, including: (i) structure, dynamics, and function of biomolecules and supramolecular assemblies, especially under physiological conditions (Molecular Biophysics); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information (Genetic Mechanisms); (iii) cellular structure, properties, and function across broad spatiotemporal scales (Cellular Dynamics and Function); and (iv) systems and/or synthetic biolo...

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Many of the most pressing challenges in research and innovation require collaboration across national and disciplinary boundaries to achieve important advances. A growing number of topics are best addressed on a multilateral basis, building partnerships that leverage diverse expertise, data, infrastructure, and perspectives to advance understanding on critical topics of regional or global importance. At the same time, funders, research organizations, and researchers alike typically have limited experience with multilateral partnerships. The Office of International Science and Engineering’s MultiPLEx program seeks to support visionary, and ambitious international multilateral research partnerships that are required to hasten progress in addressing grand challenges by leveraging research excellence in the U.S. and around the globe. The program also seeks to advance understanding of effective multilateral collaboration. MultiPLEx welcomes proposals that Address urgent research and/or societal challenge of global importance (including but not limited to critical and emerging technology research) and require an inherently international multilateral approach to achieve impactful research results, partnering with at least two countries other than the U.S. Proposals that engage partners across distinct geographic regions are an area of interest. Make clear how the proposed international collaboration will enable research advances and broader impacts that go beyond what can be accomplished by a narrower team. Include a diverse group of U.S. institutions and/or individuals, leveragin...

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