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The Engineering Biological and Biomedical Systems (EBBS) program expands our understanding of biological and physiological systems, and it helps improve human health. For U.S. leadership in biotechnology, the engineering of biology is required at every scale. Engineering is needed for sensing biomarkers to making proteins to restoring functions of the body. In EBBS, fundamental mechanistic insights are combined with experimental and computational techniques. This approach helps develop platforms, devices, organisms, tissues, and processes that bring new understanding and control of biological functions. EBBS supports studies of mechanisms that drive the behavior of microbial populations and cells, and of therapeutic cells and tissues. This includes discovering the underlying engineering principles that are needed to capture the responses of biological systems and bioreactors. It also includes the creation of novel biosensing platforms and new optical imaging and modulation strategies. Research that enables the design of biological systems to sense and respond to novel stimuli is welcome. Similarly, projects leading to insight into tissue changes or injury, and to systems that imitate or restore the functions of tissues or organs are encouraged. Projects that advance rehabilitation engineering through new theories and approaches are supported by the EBBS program. Fundamental engineering research driven by the needs of persons with disabilities is encouraged. The EBBS program expands what is possible in biomanufacturing; research may advance biotechnology and/or health. EBBS....

The Engineering Environmental Resiliency (EER) program supports fundamental research to advance resource and energy conservation and recovery, and to safeguard the natural environment and human health. Better use of domestic resources will help make U.S. manufacturing and energy systems more resilient and secure. EER projects advance artificial intelligence; biotechnology; quantum science and engineering; nanoengineering; microelectronics; and other national priorities. EER supports research that transforms biotechnology and manufacturing to create domestic sources of energy; engineered chemical, biological, and/or geo-physical processes may be involved. The program supports studies on the sustainability of benign manufacturing. EER supports the development of innovative technologies that minimize or re-use waste discharges to soil, water, and air by closing resource loops. EER also supports research on sustainable recycling and management of waste materials and critical minerals. EER supports studies on life cycle assessment, materials flow analysis, and AI modeling to advance the circular economy. EER research encompasses the chemistry, biochemistry, transport, and fate of nutrients and contaminants of emerging concern in air, water, soil, and sediments. It also includes the biochemical reactivity of pollutants in the built environment. EER welcomes ideas that grow fundamental and quantitative understanding of how nanomaterials and nanosystems interact with biological and environmental media. The program also supports research on engineered systems that safeguard health a...

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