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Many of the most pressing challenges in research and innovation require collaboration across national and disciplinary boundaries to achieve important advances. A growing number of topics are best addressed on a multilateral basis, building partnerships that leverage diverse expertise, data, infrastructure, and perspectives to advance understanding on critical topics of regional or global importance. At the same time, funders, research organizations, and researchers alike typically have limited experience with multilateral partnerships. The Office of International Science and Engineering’s MultiPLEx program seeks to support visionary, and ambitious international multilateral research partnerships that are required to hasten progress in addressing grand challenges by leveraging research excellence in the U.S. and around the globe. The program also seeks to advance understanding of effective multilateral collaboration. MultiPLEx welcomes proposals that Address urgent research and/or societal challenge of global importance (including but not limited to critical and emerging technology research) and require an inherently international multilateral approach to achieve impactful research results, partnering with at least two countries other than the U.S. Proposals that engage partners across distinct geographic regions are an area of interest. Make clear how the proposed international collaboration will enable research advances and broader impacts that go beyond what can be accomplished by a narrower team. Include a diverse group of U.S. institutions and/or individuals, leveragin...

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Large-scale simulations and the ability to accumulate massive amounts of data have revolutionized science and engineering. The goal of the Computational and Data-enabled Science and Engineering (CDS&E) meta-program is to identify and capitalize on opportunities for major scientific and engineering breakthroughs through new computational and data-analysis approaches and best practices. The CDS&E meta-program supports projects that harness computation and data to advance knowledge and accelerate discovery above and beyond the goals of the participating individual programs. The intellectual drivers may be in an individual discipline or cut across more than one discipline in various Divisions and Directorates. A CDS&E proposal should enable and/or utilize the development and adaptation of advances in research and infrastructure in computational and data science. The CDS&E meta-program encourages research that pushes the envelope of science and engineering through computation and data, welcoming proposals in any research area supported by the participating divisions. A proposal may address topics that develop or enable interactions among theory, computing, experiment, and observation to achieve progress on hitherto intractable science and engineering problems. Areas of emphasis for CDS&E vary by program. PIs are advised to consult the "related programs" links below before submitting. The CDS&E meta-program is not intended to replace existing programs that support projects involving computation or the analysis of large or complex data sets using established methods. Rather, propo...