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MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, subcellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk. This solicitation calls for proposals in research areas supported by the four MCB core clusters, including: (i) structure, dynamics, and function of biomolecules and supramolecular assemblies, especially under physiological conditions (Molecular Biophysics); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information (Genetic Mechanisms); (iii) cellular structure, properties, and function across broad spatiotemporal scales (Cellular Dynamics and Function); and (iv) systems and/or synthetic biolo...

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The principal objective of the NOAA Great Lakes Fish Habitat Restoration Partnership Grants competition is to provide federal financial and technical assistance to habitat restoration projects that meet NOAA's mission to restore coastal habitats and support the Great Lakes Restoration Initiative (GLRI) (https://www.epa.gov/sites/default/files/2019-10/documents/glri-action-plan-3-201910-30pp.pdf) goal to protect and restore habitats to sustain healthy populations of native fish species in the eight U.S. Great Lakes states. Proposals submitted under this solicitation will be evaluated based on alignment with our program priorities, including: 1) contribution to GLRI Focus Area 1 (Toxic Substances and Areas of Concern) goals to implement management actions within Areas of Concern (AOC), and 2) contribution to GLRI Focus Area 4 (Habitats and Species) goals to restore habitat for native Great Lakes fish species whose populations have been impacted by habitat degradation. Through this solicitation, we intend to address GLRI Focus Area 4 goals by prioritizing a subset of habitat restoration projects identified by the Lake Committees as Environmental Priorities to meet fish community objectives for Great Lakes fish species. Lake Committees are composed of senior officials from state, provincial, and U.S. intertribal fishery agencies, convened by the Great Lakes Fishery Commission. Together, they are responsible for managing the Lakes’ fisheries and developing plans and guidance to sustain healthy populations of Great Lakes commercial and recreational fish species. *Please note that...

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