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The goal of the NIGMS Predoctoral Basic Biomedical Sciences Research Training Program is to develop a pool of well-trained scientists available to address the Nations biomedical research agenda. Specifically, this funding opportunity announcement provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical graduate training and mentoring that will keep pace with the rapid evolution of the biomedical research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation.

The purpose of this Notice of Funding Opportunity (NOFO) is to provide continuing support for specific pathogen-free (SPF) macaque colonies previously funded under the auspices of PAR-21-089 and PAR-18-669 that support Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Breeding colonies are essential to sustain appropriate SPF macaques for research related to HIV/AIDS. Pedigree SPF macaques are free of certain viruses, which may confound the results of HIV/AIDS-related investigations or present a risk to the personnel who care for the animals. The SPF macaques are genetically characterized for major histocompatibility complex (MHC) class I types, because MHC class I genotypes have large effects on macaque immune responses to Simian Immunodeficiency Virus (SIV) that can induce AIDS in nonhuman primates (NHPs) and on human immune responses to HIV.

The purpose of the Resource-Related Research Projects (R24) grant is to support investigator-initiated resources designed to provide materials and services to support and advance biomedical research on a national basis. An R24 resource grant mechanism is a non-hypothesis-driven activity to provide data, materials, tools, or services that are essential to making timely, high quality, and cost-efficient progress in a field. Hypothesis-driven research applications should not be submitted in response to this program announcement but to another mechanism that encourages this type of research. The resource should be available to any qualified investigator, and should be highly quality controlled, and not duplicate resources available commercially or through other sources. Resources should be designed to provide services to the broad alcohol research community and should not be limited by any specific regional focus.

The Office of Research Infrastructure Programs (ORIP) invites grant applications from core facilities, resource centers, animal vivaria, or individual investigators of other shared resources to systematically study the roles of critical environmental extrinsic factors in biological, behavioral, and treatment studies using animal model species, with the objective of enhancing the rigor and reproducibility of animal research. The research area must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate the biological processes that impact multiple organ systems in order to align with the ORIPs NIH-wide mission and programs. The program supports the acquisition or update of modern equipment for measuring, monitoring, recording, and reporting environmental, biological or biobehavioral variables. The equipment requested must be capable of recording and reporting multiple parameters simultaneously.

This Notice of Funding Opportunity (NOFO) invites eligible academic or research institutions to apply for funding support to purchase latest scientific equipment that will enhance and modernize research-supporting operations of existing shared biomedical research facilities. Targeted are laboratory research core facilities, animal research facilities, and other similar shared-use research spaces. The goal of this NOFO is to strengthen research-auxiliary activities of biomedical research facilities and to enhance the efficiency of their operations. The NOFO does not support the purchase of scientific research instruments or their components, nor components of building-level infrastructure equipment that indirectly support research activities.

The specific purpose of this Notice of Funding Opportunity (NOFO) is to promote the development of a diverse, interdisciplinary workforce needed to conduct translational research on Alzheimer's disease and Alzheimer's-related dementias from target discovery through clinical development. This NOFO will support institutional training programs for predoctoral and postdoctoral level researchers with diverse educational backgrounds (i.e., basic biology, translational and clinical research, data science). The program invites eligible institutions to develop interdisciplinary training programs that will provide trainees with the knowledge and skills in data science, disease biology, behavioral research, and traditional and emerging drug discovery disciplines necessary to conduct rigorous and cutting-edge basic, translational, and clinical research for AD/ADRD.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research. To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: (1) Research Experiences, (2) Curriculum or Methods Development and (3) Outreach. The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer. This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers. To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences. The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills. In alignment with these goals, institutions may develop unique programs that capitalize....

The purpose of this announcement is to encourage investigators to pursue a small clinical trial to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical trial to answer key questions about the function or final design of a device.As part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices' exis...

The purpose of this announcement is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.

The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-24-272). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.

Our world is at a pivotal moment where the boundaries dividing the physical and social worlds from the cyber world have become blurred. Cyberspace has evolved from an interconnected digital environment into a complex and interdependent cyber ecosystem that involves hardware, software, networks, data, people, organizations, countries, and the physical world. Critical functions of everyday life are deeply intertwined with computing, including health, government, commerce, the public sphere, education, critical infrastructure, interpersonal communication, and transportation. The complexity and inter-dependencies in cyberspace can be misused and exploited by malicious actors. These in turn can trigger adverse outcomes such as disruption of critical infrastructure and systems; theft of intellectual property and sensitive data; amplification of inequalities; disclosure of private information of individuals, organizations, and governments; and threats to lives, livelihoods, and reputations. Furthermore, constant attacks on the data and assets of corporations, governments, and individuals undermine people’s trust in decision-making and processes that depend critically on these cyber systems. The Security, Privacy, and Trust in Cyberspace (SaTC 2.0) program aims to build trust in global cyber ecosystems. Trust is the core tenet of this program and, for the purposes of this solicitation, is broadly defined to include our confidence in the security, privacy, and resilience of cyberspace, particularly in the face of malicious intent. Achieving this level of confidence in cyberspace req...

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NIDCD R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

The integration of Artificial Intelligence (AI) and Biological Research has the potential to pave the way for breakthroughs in biotechnology and bio-system design that will create innovations, new industries, and jobs. To capitalize on this promise, the Directorate for Biological Sciences (BIO) will make awards for Postdoctoral Research Fellowships in Biology (PRFB) to recent doctoral degree recipients, for proposals with a research and training focus at the Intersection of Artificial Intelligence and Biological Sciences to Strengthen and Safeguard Biotechnology Innovations. Applying AI to highly complex biological systems will reveal unknown mechanisms in the natural world that hold promise for technological developments. Candidates with AI and/or biology experience will develop deep expertise in both by proposing additional training in both areas. These combinations of current expertise and new cross-training will produce scientists who work seamlessly at the intersection of AI and biology. The fellows are expected to become field leaders who use AI capabilities to extrapolate from biological data to technological advances. Proposers are encouraged to consider how to leverage the nation’s diversity of existing biological data, and biological infrastructure, such as Biofoundries, Programmable Cloud Labs, Manufacturing USA Institutes, and NEON, to accelerate discovery, innovation and the biotechnology that improves human lives, promotes the U.S. economy, and benefits the nation.

Scope:Proposals must demonstrate their disruptive impact on defence applications in order to accelerate the creation and deployment of novel solutions for armed forces and support the uptake of new civilian innovations in the defence sector. Proposals must focus on enhancing operational readiness and effectiveness, improving strategic decision-making and addressing emerging threats through cutting-edge technologies or products. Solutions must embrace disruption to enable armed forces to gain a technological edge and adapt to rapidly evolving security challenges, ultimately ensuring radical technological superiority over potential adversaries. Proposals must address disruptive knowledge, products and technologies in any area of defence interest reaching at least TRL4 .The funded actions should aim to achieve a rapid time-to-market. Management mode: Action implemented in indirect managemen...

Scope:The proposals must demonstrate their disruptive impact on defence applications and address innovative technologies and solutions for defence, including those that can improve the readiness, deployability, reliability, safety and sustainability of forces in defence tasks and missions, for example in terms of operations, equipment, infrastructure, energy solutions, surveillance systems or digital solutions. Proposals must address disruptive knowledge, products and technologies in any area of defence interest (8 ) reaching at least TRL 4 (9 ).In addition, to best complement R&D efforts that already target civil applications and encourage the efficient spinning-in of knowledge, innovation and technological development to the defence sector, this topic also welcomes proposals for add-on research actions to adapt solutions originally developed for civilian applications and previously not...

Scope:The proposals must address innovative defence products, solutions and technologies, including those that can improve readiness, deployability, reliability, safety and sustainability of forces in defence tasks and missions, for example in terms of operations, equipment, infrastructure, energy solutions, surveillance systems or digital solutions.Proposals must address disruptive knowledge, products and technologies in any area of defence interest([1]) from TRL 4 and above([1]).In addition, to best complement R&D efforts that already target civil applications and encourage the efficient spinning-in of knowledge, innovation and technological development to the defence sector, this call topic also welcomes proposals for add-on development actions to adapt solutions originally developed for civil applications and previously not applied in the defence sector.Management mode: Action implem...

Scope:Assisting soldiers with robots and drones that can provide accurate tactical situational awareness by using AI becomes essential for soldier protection. This call topic aims to follow on and complement previous activities in the field of hidden threat detection and explore solutions involving various combinations of intelligent robots, drones and sensing technologies for advanced detection and recognition of threats, in view of their avoidance or neutralisation.These solutions should be tested under realistic scenarios in a comparable and objective manner to reach up to Technical Readiness Level (TRL) 6. For that purpose, each consortium supported through this call topic will benefit from a common testing environment set up as part of a technological challenge and will have to participate in the experiment campaigns organised with this objective.Beyond defence technologies, this to...

Scope:The automatic analysis of tactical situations using fleets of robots, drones and AI is an important research topic that lacks standardised benchmarks and objective evaluation campaigns. This call topic aims to set up a testing environment and organise a technological challenge in which research teams will participate, supported by another topic (EDF-2024-LS-RA-CHALLENGE-DIGIT-AISAP-STEP) and possibly other sources of funding. The testing environment should enable objective comparisons between different approaches. Data should be collected during field tests, annotated and shared to enable the validation of the system performances based on precise evaluation criteria and plans, to be provided as part of the call document.Targeted types of activities: Integrating knowledge, not excluding upstream and downstream activities eligible for research actions.Indicative budget: EUR 7 000 000...

Scope:An unmanned aerial vehicle used as unmanned loyal wingman/unmanned combat aerial vehicle requires specific performance for a variety of mission profiles to meet storage, deployment and operational requirements. In particular, an engine that provides optimum thrust and electrical power capabilities is required to meet these performance requirements.Against this background, the aim of this topic is to investigate a new turbofan engine in the range of approximately 25-35 kN that meets all feasible military requirements and is capable of operating on kerosene, hydrogen (H2) and sustainable aviation fuel.This topic contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of defence technologies. Targeted types of activities: Generating knowledge, integrating knowledge, studies and design.Indicative budget: EUR 20 000 000 for this topic under the...

Scope:This topic aims to improve the protection of seabed infrastructure through a comprehensive system, including unmanned assets, advanced sensors, underwater observation, detection, acquisition and communication systems, and integrated command and control. This initiative focuses on the development and validation of such a system for future operations, integrated with maritime command centres for coordinated responses. The approach combines operational levels and innovative technologies to effectively mitigate risk and ensure continuity of operations.Beyond defence technologies, this topic also contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of deep and digital technologies. Targeted types of activities: Studies and design, not excluding upstream activities eligible for research actions.Indicative budget: EUR 30 000 000 for this topic...

Scope:In order to increase situational awareness and operational superiority, improved detection, tracking and identification capabilities over large areas with increased range and minimum latency are required. High-frequency (HF) over-the-horizon (OTH) systems therefore need to be improved, while an EU concept for a cognitive and scalable network of HF OTH sensors could be further explored.The objective of this topic is to follow up and complement previous activities in the field of OTH, in particular the development of technologies for an EU OTH radar network concept providing deep cooperation and data sharing for strategic surveillance. In this context, both HF surface (active, cooperative and non-cooperative passive) and skywave radar technologies should be explored and integrated for their respective advantages in terms of area covered at long ranges and as a gap filler in an agile...

COE for Technical Training and Human Performance

The Analysis Program supports research in analysis. Areas of current activity include complex, harmonic, and real analysis; dynamical systems and ergodic theory; functional analysis; mathematical physics; operator theory and operator algebras; partial differential equations and calculus of variations. Conferences Proposals to the Analysis Program for conferences or workshops must be submitted through the program solicitation "Conferences and Workshops in the Mathematical Sciences" (link below). Principal Investigators should carefully read the solicitation to obtain important information regarding the substance of proposals for conferences, workshops, and similar activities. To facilitate timely notification of the availability of support, proposals for conferences, workshops, and similar activities should be submitted 8 months in advance of the start date of the proposed event.

This solicitation applies to six (of the nine) CHE Disciplinary Research Programs: Chemical Catalysis (CAT); Chemical Measurement and Imaging (CMI); Chemical Mechanism, Function and Properties (CMFP); Chemical Synthesis (SYN); Environmental Chemical Sciences (ECS); and Macromolecular, Supramolecular and Nanochemistry (MSN). All proposals submitted to these six CHE Disciplinary Research Programs (other than the following exceptions) must be submitted through this solicitation, otherwise they will be returned without review. Exceptions: Faculty Early Career Development Program (CAREER) proposals should be submitted through the CAREER solicitation (https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214) by the CAREER deadline date specified. Facilitating Research at Primarily Undergraduate Institutions: Research in Undergraduate Institutions (RUI) and Research Opportunity Awards (ROA) proposals should be submitted through the RUI/ROA solicitation (https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5518) during the window for the appropriateCHE Disciplinary Research Program. In addition to the requirements of the RUI program, proposals should follow the guidance in this solicitation. Proposals for Early-concept Grants for Exploratory Research (EAGER), Grants for Rapid Response Research (RAPID), Research Advanced by Interdisciplinary Science and Engineering (RAISE), and conferences can be submitted anytime after consultation with the cognizant NSF Program Officer. Supplemental funding requeststo existing grantscan be submitted anytime after consultation with the cognizant NSF Pro...

The U.S. Department of Labor’s (DOL) Veterans’ Employment and Training Service (VETS) supports local Stand Down events that assist veterans experiencing homelessness by providing a wide range of employment, social, and health services.Stand Down is a military term referring to an opportunity to achieve a brief respite from combat. Troops assemble in a base camp to receive new clothing, hot food, support services, and a relative degree of safety before returning to combat action. A DOL VETS-funded Stand Down event serves a similar purpose; however, it is intended for veterans experiencing or at-risk of homelessness. The critical services provided at these events are often the catalyst that enables those individuals to reenter the workforce. VETS awards these noncompetitive grants on a first-come, first-served basis to support one-day or multi-day events at up to $7,000 or $10,000, respectively. They are collaborative events coordinated between VA, DOL, other federal, state, and local government agencies and community-based organizations providing services and supplies to veterans experiencing and at risk of homelessness. In the event of a federal disaster declaration, VETS will accept applications up to $50,000 to conduct Stand Down events in the impacted areas.VETS awards Stand Down grants subject to the availability of federal funding. All costs incurred by the award recipient prior to the period of performance start date identified in the Notice of Award issued by the Department are incurred at the recipient’s own expense.