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The goal of the NIGMS Predoctoral Basic Biomedical Sciences Research Training Program is to develop a pool of well-trained scientists available to address the Nations biomedical research agenda. Specifically, this funding opportunity announcement provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical graduate training and mentoring that will keep pace with the rapid evolution of the biomedical research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation.

The Office of Research Infrastructure Programs (ORIP) invites grant applications from core facilities, resource centers, animal vivaria, or individual investigators of other shared resources to systematically study the roles of critical environmental extrinsic factors in biological, behavioral, and treatment studies using animal model species, with the objective of enhancing the rigor and reproducibility of animal research. The research area must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate the biological processes that impact multiple organ systems in order to align with the ORIPs NIH-wide mission and programs. The program supports the acquisition or update of modern equipment for measuring, monitoring, recording, and reporting environmental, biological or biobehavioral variables. The equipment requested must be capable of recording and reporting multiple parameters simultaneously.

This Notice of Funding Opportunity (NOFO) invites eligible academic or research institutions to apply for funding support to purchase latest scientific equipment that will enhance and modernize research-supporting operations of existing shared biomedical research facilities. Targeted are laboratory research core facilities, animal research facilities, and other similar shared-use research spaces. The goal of this NOFO is to strengthen research-auxiliary activities of biomedical research facilities and to enhance the efficiency of their operations. The NOFO does not support the purchase of scientific research instruments or their components, nor components of building-level infrastructure equipment that indirectly support research activities.

The specific purpose of this Notice of Funding Opportunity (NOFO) is to promote the development of a diverse, interdisciplinary workforce needed to conduct translational research on Alzheimer's disease and Alzheimer's-related dementias from target discovery through clinical development. This NOFO will support institutional training programs for predoctoral and postdoctoral level researchers with diverse educational backgrounds (i.e., basic biology, translational and clinical research, data science). The program invites eligible institutions to develop interdisciplinary training programs that will provide trainees with the knowledge and skills in data science, disease biology, behavioral research, and traditional and emerging drug discovery disciplines necessary to conduct rigorous and cutting-edge basic, translational, and clinical research for AD/ADRD.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network (MetNet). Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. The projects should use integrative system level approaches to elucidate and integrate a mechanistic understanding of the non-linear, dynamic, and emergent processes in metastasis. Overarching themes should encompass the interplay between at least two central elements in the metastatic process such as early dissemination, cellular, soluble and/or physical microenvironment crosstalk, dormancy, or mechanisms of responses by metastatic cells to therapies. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers.Research proposed by MetNet Centers is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research. To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: (1) Research Experiences, (2) Curriculum or Methods Development and (3) Outreach. The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer. This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers. To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences. The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills. In alignment with these goals, institutions may develop unique programs that capitalize....

The purpose of this announcement is to encourage investigators to pursue a small clinical trial to obtain critical information necessary to advance recording and/or stimulating devices to treat central nervous system disorders and better understand the human brain (e.g., Early Feasibility Study). Clinical studies supported may consist of acute or short-term procedures that are deemed Non-Significant Risk (NSR) by an Institutional Review Board (IRB), or Significant Risk (SR) studies that require an Investigational Device Exemption (IDE) from the FDA, such as chronic implants. The clinical trial should provide data to answer key questions about the function or final design of a device. This final device design may require most, if not all, of the non-clinical testing on the path to more advanced clinical trials and market approval. The clinical trial is expected to provide information that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. Activities supported by this Funding Opportunity include a small clinical trial to answer key questions about the function or final design of a device.As part of the BRAIN Initiative, NIH has initiated a Public-Private Partnership Program (BRAIN PPP) that includes agreements (Memoranda of Understanding, MOU) with a number of device manufacturers willing to make such devices available, including devices and capabilities not yet market approved but appropriate for clinical research. In general it is expected that the devices' exis...

The purpose of this announcement is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.

The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-24-272). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.

Our world is at a pivotal moment where the boundaries dividing the physical and social worlds from the cyber world have become blurred. Cyberspace has evolved from an interconnected digital environment into a complex and interdependent cyber ecosystem that involves hardware, software, networks, data, people, organizations, countries, and the physical world. Critical functions of everyday life are deeply intertwined with computing, including health, government, commerce, the public sphere, education, critical infrastructure, interpersonal communication, and transportation. The complexity and inter-dependencies in cyberspace can be misused and exploited by malicious actors. These in turn can trigger adverse outcomes such as disruption of critical infrastructure and systems; theft of intellectual property and sensitive data; amplification of inequalities; disclosure of private information of individuals, organizations, and governments; and threats to lives, livelihoods, and reputations. Furthermore, constant attacks on the data and assets of corporations, governments, and individuals undermine people’s trust in decision-making and processes that depend critically on these cyber systems. The Security, Privacy, and Trust in Cyberspace (SaTC 2.0) program aims to build trust in global cyber ecosystems. Trust is the core tenet of this program and, for the purposes of this solicitation, is broadly defined to include our confidence in the security, privacy, and resilience of cyberspace, particularly in the face of malicious intent. Achieving this level of confidence in cyberspace req...

Summary: Initially created in fiscal year 2019 (FY19), the Kidney Cancer Research Program (KCRP) Academy of Kidney Cancer Investigators (AKCI) is a unique interactive virtual academy providing intensive mentoring, national networking, collaborations, and a peer group for junior faculty. The Academy pairs Early Career Scholars (ECS) with established investigators (Designated Mentors) under the oversight of the AKCI Leadership Team, a Designated Mentor Panel, and the Kidney Cancer Patient Advocates Panel. The AKCI’s overarching goal is to conduct innovative and impactful kidney cancer research while also developing a vital resource, a network of highly productive kidney cancer researchers conducting cutting edge research that advances the state of the field in kidney cancer and leads to new treatments for individuals living with kidney cancer.Distinctive Features:·        Early-Career Scholar: The FY26 KCRP AKCI-ECSA focuses on both the Scholar’sresearch and their career potential in the kidney cancer field.·        Designated Mentor: The Designated Mentor must have a strong record of successful mentorship coupled with a strong record of funding (past and present) and publications in kidney cancer research.·        Preliminary Data: Preliminary data to support the feasibility of the research and approaches are required; however, these data do not need to be derived from the kidney cancer research field.

Summary: The fiscal year 2026 (FY26) Kidney Cancer Research Program (KCRP) Idea Development Award (IDA) supports the development of high-impact ideas that advance the understanding of kidney cancer and ultimately lead to improved patient outcomes. The research project should include a well-formulated, testable hypothesis based on strong scientific rationale and a well-developed and articulated research approach. Personnel on the proposed team should have a strong background in kidney cancer research.Distinctive Features:·        Partnering Principal Investigator Option: Supports meaningful and productive partnerships between two investigators, termed the Initiating Principal Investigator (PI) and Partnering PI, collaborating on a single application. Only the Initiating PI will submit a pre-application, but all PIs will need to submit full applications. The Partnering PI’s application is an abbreviated package specific to their distinct portion of the research project. Be advised, all associated applications for a research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn.

This is a non-competitive funding opportunity intended to fund a single award. The National Institute of Neurological Disorders and Stroke is announcing its intent to issue a single source cooperative agreement award to Massachusetts General Hospital to support the renewal of the Post-Stroke Vascular Cognitive Impairment & Dementia (VCID) program, an ongoing, multi-site clinical research initiative designed to elucidate mechanisms linking stroke to subsequent cognitive impairment and dementia. The award will enable completion of the scientific aims initiated under the original U19 cooperative agreement (RFA-NS-19-012) and advance national priorities described in the National Plan to Address Alzheimer"s Disease.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from Massachusetts General Hospital. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and only meritorious application(s) will be considered for funding.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NIDCD R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

The integration of Artificial Intelligence (AI) and Biological Research has the potential to pave the way for breakthroughs in biotechnology and bio-system design that will create innovations, new industries, and jobs. To capitalize on this promise, the Directorate for Biological Sciences (BIO) will make awards for Postdoctoral Research Fellowships in Biology (PRFB) to recent doctoral degree recipients, for proposals with a research and training focus at the Intersection of Artificial Intelligence and Biological Sciences to Strengthen and Safeguard Biotechnology Innovations. Applying AI to highly complex biological systems will reveal unknown mechanisms in the natural world that hold promise for technological developments. Candidates with AI and/or biology experience will develop deep expertise in both by proposing additional training in both areas. These combinations of current expertise and new cross-training will produce scientists who work seamlessly at the intersection of AI and biology. The fellows are expected to become field leaders who use AI capabilities to extrapolate from biological data to technological advances. Proposers are encouraged to consider how to leverage the nation’s diversity of existing biological data, and biological infrastructure, such as Biofoundries, Programmable Cloud Labs, Manufacturing USA Institutes, and NEON, to accelerate discovery, innovation and the biotechnology that improves human lives, promotes the U.S. economy, and benefits the nation.

The National Endowment for the Arts’ State & Regional Partnership Agreement grants are awarded to the nation’s 56 state and jurisdictional arts agencies (SAAs), and the six regional arts organizations (RAOs) whose members comprise SAAs.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the next 5-year award period of the Clinician-Scientist Transdisciplinary Aging Research Coordinating Center (Clin-STAR CC), whose mission is to serve as a national resource for clinician-investigators across specialties and disciplines who are focusing their careers on aging research. This NOFO intends to build upon NIA's substantial investments to foster the development of clinician-scientists across specialties and disciplines. The specific goals of this initiative are to convey scientific and research knowledge on aging research; foster networking and collaboration between clinician-scientist leaders in aging research and clinician-investigators across specialties and disciplines who wish to focus on aging research; provide mentoring and career development support for emerging clinician-scientists committed to pursuing aging research in their clinical specialty or discipline; and advance interdisciplinary research projects in aging. Ultimately, the Clin-STAR CC is intended to provide a multi-faceted national research platform leading to improved patient-centered care for older adults across specialties and disciplines.

Scope:In order to increase situational awareness and operational superiority, improved detection, tracking and identification capabilities over large areas with increased range and minimum latency are required. High-frequency (HF) over-the-horizon (OTH) systems therefore need to be improved, while an EU concept for a cognitive and scalable network of HF OTH sensors could be further explored.The objective of this topic is to follow up and complement previous activities in the field of OTH, in particular the development of technologies for an EU OTH radar network concept providing deep cooperation and data sharing for strategic surveillance. In this context, both HF surface (active, cooperative and non-cooperative passive) and skywave radar technologies should be explored and integrated for their respective advantages in terms of area covered at long ranges and as a gap filler in an agile...

Scope:Assisting soldiers with robots and drones that can provide accurate tactical situational awareness by using AI becomes essential for soldier protection. This call topic aims to follow on and complement previous activities in the field of hidden threat detection and explore solutions involving various combinations of intelligent robots, drones and sensing technologies for advanced detection and recognition of threats, in view of their avoidance or neutralisation.These solutions should be tested under realistic scenarios in a comparable and objective manner to reach up to Technical Readiness Level (TRL) 6. For that purpose, each consortium supported through this call topic will benefit from a common testing environment set up as part of a technological challenge and will have to participate in the experiment campaigns organised with this objective.Beyond defence technologies, this to...

Scope:The proposals must address innovative defence products, solutions and technologies, including those that can improve readiness, deployability, reliability, safety and sustainability of forces in defence tasks and missions, for example in terms of operations, equipment, infrastructure, energy solutions, surveillance systems or digital solutions.Proposals must address disruptive knowledge, products and technologies in any area of defence interest([1]) from TRL 4 and above([1]).In addition, to best complement R&D efforts that already target civil applications and encourage the efficient spinning-in of knowledge, innovation and technological development to the defence sector, this call topic also welcomes proposals for add-on development actions to adapt solutions originally developed for civil applications and previously not applied in the defence sector.Management mode: Action implem...

Scope:The automatic analysis of tactical situations using fleets of robots, drones and AI is an important research topic that lacks standardised benchmarks and objective evaluation campaigns. This call topic aims to set up a testing environment and organise a technological challenge in which research teams will participate, supported by another topic (EDF-2024-LS-RA-CHALLENGE-DIGIT-AISAP-STEP) and possibly other sources of funding. The testing environment should enable objective comparisons between different approaches. Data should be collected during field tests, annotated and shared to enable the validation of the system performances based on precise evaluation criteria and plans, to be provided as part of the call document.Targeted types of activities: Integrating knowledge, not excluding upstream and downstream activities eligible for research actions.Indicative budget: EUR 7 000 000...

Scope:An unmanned aerial vehicle used as unmanned loyal wingman/unmanned combat aerial vehicle requires specific performance for a variety of mission profiles to meet storage, deployment and operational requirements. In particular, an engine that provides optimum thrust and electrical power capabilities is required to meet these performance requirements.Against this background, the aim of this topic is to investigate a new turbofan engine in the range of approximately 25-35 kN that meets all feasible military requirements and is capable of operating on kerosene, hydrogen (H2) and sustainable aviation fuel.This topic contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of defence technologies. Targeted types of activities: Generating knowledge, integrating knowledge, studies and design.Indicative budget: EUR 20 000 000 for this topic under the...

Scope:This topic aims to improve the protection of seabed infrastructure through a comprehensive system, including unmanned assets, advanced sensors, underwater observation, detection, acquisition and communication systems, and integrated command and control. This initiative focuses on the development and validation of such a system for future operations, integrated with maritime command centres for coordinated responses. The approach combines operational levels and innovative technologies to effectively mitigate risk and ensure continuity of operations.Beyond defence technologies, this topic also contributes to the STEP objectives as defined in the STEP Regulation in the target investment area of deep and digital technologies. Targeted types of activities: Studies and design, not excluding upstream activities eligible for research actions.Indicative budget: EUR 30 000 000 for this topic...

Scope:Proposals must demonstrate their disruptive impact on defence applications in order to accelerate the creation and deployment of novel solutions for armed forces and support the uptake of new civilian innovations in the defence sector. Proposals must focus on enhancing operational readiness and effectiveness, improving strategic decision-making and addressing emerging threats through cutting-edge technologies or products. Solutions must embrace disruption to enable armed forces to gain a technological edge and adapt to rapidly evolving security challenges, ultimately ensuring radical technological superiority over potential adversaries. Proposals must address disruptive knowledge, products and technologies in any area of defence interest reaching at least TRL4 .The funded actions should aim to achieve a rapid time-to-market. Management mode: Action implemented in indirect managemen...

Scope:The proposals must demonstrate their disruptive impact on defence applications and address innovative technologies and solutions for defence, including those that can improve the readiness, deployability, reliability, safety and sustainability of forces in defence tasks and missions, for example in terms of operations, equipment, infrastructure, energy solutions, surveillance systems or digital solutions. Proposals must address disruptive knowledge, products and technologies in any area of defence interest (8 ) reaching at least TRL 4 (9 ).In addition, to best complement R&D efforts that already target civil applications and encourage the efficient spinning-in of knowledge, innovation and technological development to the defence sector, this topic also welcomes proposals for add-on research actions to adapt solutions originally developed for civilian applications and previously not...