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This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. In addition to preclinical efficacy, accompanying pharmacodynamic and pharmacokinetic studies would be supported. Therapeutic agents include small molecules, biologics or biotechnology-derived products. The goal of this NOFO is to spur therapeutic development for a variety of rare diseases by advancing projects to the point where they would attract subsequent investment supporting full Investigational New Drug (IND) application development or progression to clinical trials in the case of repurposing or repositioning.

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is soliciting proposals that investigate innovative approaches that enable revolutionary advances in science, devices, or systems for national security applications. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.

Through WaterSMART, the Bureau of Reclamation (Reclamation) leverages Federal and non-Federal funding to work cooperatively with States, Tribes, and other entities as they plan for and implement actions to increase water supply and hydropower reliability. The WaterSMART Program demonstrably advances Trump administration priorities, such as those identified in Presidential Executive Order 14154 (January 20, 2025): Unleashing American Energy (E.O. 14154) and Secretarial Order 3418, and aligns with other priorities and requirements, such as those identified in Presidential Executive Order 14332 (August 7, 2025): Improving Oversight in Federal Grantmaking (E.O. 14332). The goal of the WaterSMART Small-Scale Water Efficiency Projects NOFO is to invite eligible entities to apply for funding to implement projects that conserve water and enhance water supply reliability in water delivery systems. It encourages the implementation of small-scale projects identified through prior planning efforts, such as canal lining, water delivery automation, flow measurement, and other projects that increase water efficiency.

DOE SC hereby invites applications for support under the ECRP in the following program areas: Advanced Scientific Computing Research (ASCR); Basic Energy Sciences (BES); Biological and Environmental Research (BER); Fusion Energy Sciences (FES); High Energy Physics (HEP); Nuclear Physics (NP); Isotope Research and Development and Production (DOE IP). The purpose of this program is to support the development of individual research programs of outstanding scientists early in their careers and to stimulate research careers in the areas supported by SC.

The Office of Academic Exchange Programs of the Bureau of Educational and Cultural Affairs announces an open competition for the administration of the FY 2026 Global Undergraduate Exchange Program (Global UGRAD). The total amount of funding for this award will be up to $4,800,000, pending the availability of FY 2026 funds.    The Global UGRAD Program places small cohorts of participants at a broad range of colleges and universities, including community colleges, land-grant institutions, rural campuses, and Senior Military Institutions, giving participants a “real American” experience in small towns and rural communities. Participants build skills in strategic U.S. priority fields such as business, entrepreneurship, semiconductors, AI, engineering, critical minerals, manufacturing, and supply chain resilience. All participants are required to study U.S. history, civic engagement, and American culture, deepening their understanding of American excellence, innovation, and culture. Funding should support approximately 160 participants, pending the availability of FY 2026 funds. Every effort should be made to maximize the number of scholarships awarded; staffing levels should be adequate to ensure that participant health and safety are prioritized. Please see the NOFO for additional information.

This NOFO supports basic or applied research and development of Innovations in forensic science for criminal justice purposes. These awards support a discrete, specified, circumscribed project that will: 1. Increase the body of knowledge to guide and inform forensic science policy and practice; or 2. Lead to the production of useful material(s), device(s), system(s), or method(s) that have the potential for forensic application.

This NOFO seeks proposals for rigorous applied research and evaluative studies on the forensic science system. The field of forensic science is changing, particularly as technological advancements improve the criminal justice system’s ability to use forensic evidence more effectively and efficiently. Research is needed to better understand the impact of forensic science on the criminal justice system and law enforcement operations. With this NOFO, NIJ requests applications in three topic areas: • The impact of forensic science on the criminal justice system and law enforcement operations, such as improving investigative clearance rates, increasing law enforcement effectiveness, and reducing crime lab backlogs. • Evaluations of the implementation of new and innovative forensic science methods and their impact on strengthening courtroom admissibility and evidentiary reliability. • Developing the forensic science workforce.

This funding opportunity seeks rigorous proposals on: (1) management and development of the correctional workforce; and (2) correctional officer safety. Proposals for research outside of these two topics will not be considered responsive to this NOFO. Applicants may submit more than one proposal; however, only one topic may be submitted per proposal. Applicants are requested to identify the topic addressed in their application on the title page of the proposal narrative. NIJ is particularly interested in applications with research designs that incorporate action-oriented research, where jurisdictions are an integral part of defining the program, implementing change, and revising practices based on assessment of the change. Applicants may propose a phased implementation plan if the research design and questions warrant this approach.

This is a notice of funding opportunity (NOFO) for the OJP FY 2026 Special Attorneys Program. This program will support state, local, Tribal, and territorial prosecuting agencies to assign or hire qualified prosecutors to serve full time as Special Attorneys under the direction of the National Fraud Enforcement Division or the Criminal Division, or to serve as Special Assistant United States Attorneys (SAUSAs) within a United States Attorney’s Office. These “cross-designated” prosecutors will remain employees of their home agencies but will investigate and prosecute assigned fraud and other crimes committed by aliens within the United States (hereafter referred to as “criminal aliens”) for the duration of their appointment under this program. Cross-designated prosecutors may also be assigned cases involving drug or human trafficking committed within the United States. The National Fraud Enforcement Division, Criminal Division, and United States Attorney’s Offices will coordinate with selected prosecutor offices on a case-by-case basis to address logistics and any unique local circumstances. This grant program, authorized under Public Law 119-21, Title X, Subtitle A, Part II, Section 100055 (codified at 34 U.S.C. § 61101), is intended to strengthen investigative and prosecutorial capacity, expand intergovernmental coordination, and enhance the ability of jurisdictions to investigate and prosecute fraud and other crimes committed by aliens within the United States, as well as investigate and prosecute drug and human trafficking crimes. The program is also intended to increase...

Expected Outcome:Indicative duration of the project(s) to be funded: 36 monthsQualitative and quantitative indicators: The number of collaboration activities, the scale-up achieved by SMEs in terms of volume increase and/or measurable process improvements (e.g. higher yields, lower costs), and the number of SMEs supported overall.Scope:This call will fund projects within the bioeconomy, with a special focus on biotech applied in the food sector. The projects aim at boosting collaboration between biotech clusters, creating a critical mass able to compete with global hubs. Projects will have to actively support their SMEs developing innovative products made with bio solutions, especially to scale-up from the laboratory to pilot- and commercial scale, and explore the best options to provide regulatory support to help bring those products to the market.Projects should focus on the agri-food...

The Innovation in Behavioral Health (IBH) Model (the “Model”) for Cohort II Recipients is a seven-year, voluntary service delivery and payment model promoting integrated care in behavioral health (BH) settings. The IBH Model will test the impact of a value-based payment (VBP) model aligned across Medicaid and Medicare that supports an integrated care delivery framework in specialty BH organizations and settings for adult Medicaid, Medicare, and dually eligible beneficiaries with moderate to severe mental health conditions and/or substance use disorders (SUDs).The Centers for Medicare & Medicaid Services (CMS), through its Center for Medicare & Medicaid Innovation (Innovation Center), will select up to five state Medicaid agencies (SMAs) to participate in the Model. The Model will have a seven-year performance period, which will be comprised of a two-year Pre-Implementation Period (beginning January 2027 and ending December 2028) along with a five-year Implementation Period (beginning January 2029 and ending December 2033). Up to $7.5 million dollars in cooperative agreement award funding will be available to each selected Recipient over the course of the seven years.

This funding opportunity seeks proposals for research and evaluation studies to produce practical knowledge that can improve the examination and interpretation of physical evidence in forensic science laboratories. Specifically, NIJ seeks applications for rigorous research and evaluation projects that will: • Identify and inform the forensic community of best practices through the evaluation of existing and emerging laboratory protocols; and/or • Have a direct and immediate impact on laboratory efficiency and assist in making laboratory policy decisions.

This funding opportunity seeks to fund rigorous and innovative research and evaluation projects to fill knowledge gaps in two topical areas: 1) research on malleable factors that affect school violence in K-12 schools; and 2) evaluations of the impact and effectiveness of school safety approaches implemented for purposes authorized under the STOP School Violence Act. This NOFO is released by the National Institute of Justice (NIJ) in partnership with the Bureau of Justice Assistance (BJA).

This program will support state, local, and tribal government efforts to reduce wasteful spending and inefficiencies across justice system operations and redirect that funding to target crime and other public safety and/or justice system challenges. Applicants should propose projects that address one or more urgent local justice system challenge. Applicants should use existing data and information to identify the specific challenges they will focus on and how they will refocus resources on the strategies and populations most likely to reduce crime. Jurisdictions may consider addressing challenges across the judicial system, including those related to law enforcement, prosecution, sentencing, jails and prisons, probation, and parole.

Expected Impact:Individual Level:The grants should lead to a documented, significant, and measurable increase in the permitting management capacity of the beneficiary authority.Project Level:Achieve a significant acceleration of the impacted permitting processes for beneficiaries.Deploy state-of-the-art software solutions for most impacted authorities in in net- zero acceleration valleys. Scope:The call for proposals is aimed at local authorities involved in industrial permitting procedures. These procedures typically encompass a range of permits necessary for ensuring compliance with environmental, safety, and operational standards. Examples include Environmental Impact Assessments (EIA) for projects with potential environmental effects, Integrated Pollution Prevention and Control (IPPC) permits for pollution management, and various construction and operational permits. The direct award...

The purpose of this notice of funding opportunity (NOFO) is to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal of this research is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines.

This program, administered by the Washington Headquarters Services (WHS) of the Department of War (DoW), seeks to fund a Contractor to provide comprehensive bus transportation services for DoW personnel. The primary focus of this funding opportunity is to establish and operate a continual express shuttle bus service, designated as Route A90, between the Pentagon Transit Center (PTC) and the Mark Center Station (MCS) facility.The overarching goal of this program is to ensure reliable and efficient ground transportation for DoW employees in the National Capital Region. The key objectives include:• Providing driver-operated shuttle bus services.• Maintaining and inspecting all transportation vehicles to ensure safety and reliability.• Adhering to all necessary license and security requirements.• Securing appropriate vehicle insurance and liability coverage.• Ensuring buses meet capacity (seating and standing) and accessibility requirements under federal standards.Historically, the Pentagon Services Division (PSD), a component of the Executive Services Directorate (ESD) under WHS, has been responsible for providing transportation solutions to DoW employees. This NFO continues that mission by addressing the specific transportation needs created by the location of the Mark Center facility, which is not within walking distance of any mass transit facility.

The USGS Earthquake Hazards Program (EHP) issues this Notice of Funding Opportunity (NOFO) for assistance to support research in earthquake hazards, the physics of earthquakes, earthquake occurrence, and earthquake safety policy. This activity is authorized by the Earthquake Hazards Reduction Act of 1977 (Public Law 95-124, 42 U.S.C. 7701 et. seq.), and as amended by the National Earthquake Hazards Reduction Program Reauthorization Act of 2018 (Public Law 115-307).It is estimated that a total of $4 million will be awarded in support of competitive research grants in FY2027, with a maximum total of $7 million. Based on awards in recent years, approximately 50 to 70 new awards are funded each fiscal year. There is no maximum award amount (i.e., any amount may be proposed if it can be justified appropriately), however, the majority of grants range between $30,000 and $120,000. This estimate does not bind the USGS to a specified number of awards or to the amount of any award unless that amount is specified by statute or regulation.This U.S. Geological Survey (USGS) competitive grants solicitation supports external research partnerships that are essential to the Earthquake Hazards Program (EHP) mission. The goal is to generate scientific information and situational awareness products that help the program reduce deaths, injuries, and economic losses from earthquakes, and improve public safety and resilience nationwide. External grants with university, state, regional and local government agencies, and private industry partners support science that cannot be conducted within the....

OJP is committed to advancing work that furthers DOJ’s mission to uphold the rule of law, to keep our country safe, and to protect civil rights. OJP provides federal leadership, funding, and other critical resources to directly support law enforcement, combat violent crime, protect American children, provide services to American crime victims, and address public safety challenges, including human trafficking and the opioid crisis. This NOFO will provide assistance to state, local, and tribal correctional agencies and facilities to prevent, detect, and respond to sexual abuse and sexual harassment, as well as implement the National Prison Rape Elimination Act (PREA) Standards.

The Global Leaders Division in the Office of Citizen Exchanges at the U.S. Department of State’s Bureau of Educational and Cultural Affairs (ECA) seeks proposals for a cooperative agreement to design, implement, and oversee the FY 2026 Young Leaders of the Americas Initiative (YLAI) Fellowship Program. YLAI advances U.S. economic interests and leadership by fostering business partnerships between emerging entrepreneurs from the Western Hemisphere and U.S. companies. The program combines in-person and technology-driven engagement, an active alumni network, and ongoing collaboration with U.S. embassies to promote U.S. commercial priorities, create new opportunities for American companies in key markets, and increase public awareness of American business leadership. YLAI directly supports U.S. national security and the Administration’s foreign policy objectives by strengthening commercial ties, expanding U.S. exports, and promoting American values of entrepreneurship, free enterprise, and innovation throughout the Western Hemisphere. The FY 2026 program will bring approximately 250 participants from the Caribbean and Latin America for a five to six-week fellowship, including orientation, tailored U.S. business placements, entrepreneurial training, a closing event, and post-program alumni activities. Approximately 100 U.S. participants will travel overseas to support Fellows’ action plans and develop networks that support American economic growth. Please see the announcement for additional information.

Purpose of Program: The purpose of the Special Education Parent Information Centers program is to ensure that parents of children with disabilities receive high-quality, relevant, and useful training and information to help improve outcomes for their children. CPRCs promote the effective education of children with disabilities by “strengthening the role and responsibility of parents and ensuring that families of such children have meaningful opportunities to participate in the education of their children at school and at home” (20 U.S.C. 1400(c)(5)(B)). CPRCs, consistent with the Individuals with Disabilities Education Act (IDEA) (20 U.S.C. 1472(b)(4)), meet the specific needs of families in geographically defined communities who experience significant isolation from available sources of information and support. Community Parent Resource Centers (CPRCs) promote the effective education of children with disabilities by “strengthening the role and responsibility of parents and ensuring that families of such children have meaningful opportunities to participate in the education of their children at school and at home” (20 U.S.C. 1400(c)(5)(B)). CPRCs, consistent with the Individuals with Disabilities Education Act (IDEA) (20 U.S.C. 1472(b)(4)), meet the specific needs of families in geographically defined communities who experience significant isolation from available sources of information and support. Under this priority, CPRCs must increase – parents’ capacity to help their children (a) meet developmental and functional goals and challenging academic achievement goals that h...

The U.S. Department of Agriculture (USDA), Agricultural Marketing Service (AMS), requests applications for the 2026 Fiscal Year (FY) Regional Food System Partnerships (RFSP) grant program. RFSP purpose is to support partnerships that connect public and private resources to plan and develop local and regional food systems.RFSP is part of the Local Agriculture Market Program (LAMP) umbrella program. AMS welcomes applications that meet LAMP goals (see section 3.1) to support the development, coordination, and expansion of direct producer-to-consumer marketing, local and regional food markets and enterprises, and value-added agricultural products.Approximately $4.71 million is available to fund applications under this solicitation. In FY2025, AMS funded 7 (6.5%) of the eligible applications received an awarded a total of $4,712,934.This announcement identifies the eligibility criteria for RFSP projects and applicants, and the application forms and associated instructions needed to apply for an RFSP grant. AMS will award these grants competitively to eligible applicants proposing high quality projects that meet the purpose and requirements of the program. All applications will be reviewed using merit and evaluation procedures.

The U.S. Department of Agriculture (USDA), Agricultural Marketing Service (AMS), requests applications for the 2026 fiscal year (FY) Farmers Market Promotion Program (FMPP). FMPP"s purpose is to support the development, coordination, and expansion of direct producer-to-consumer markets to increase access to and availability of locally and regionally produced agricultural products.

The U.S. Department of Agriculture (USDA), Agricultural Marketing Service (AMS), requests applications for the 2026 fiscal year (FY) Local Food Promotion Program (LFPP). LFPP"s purpose is to support the development, coordination, and expansion of local and regional food business enterprises that engage as intermediaries in indirect producer-to-consumer marketing to increase access to and availability of locally and regionally produced agricultural products.

Through this Notice of Federal Funding Opportunity, the NOAA Climate Program Office (https://cpo.noaa.gov/funding-opportunities/) of the Office of Oceanic and Atmospheric Research is soliciting proposals for the Regional Integrated Sciences and Assessments FY 2026 competition for cooperative agreements.States and communities regularly face risks from weather and climate-driven hazards, including flooding, extreme temperatures, water shortages, wildfires, and severe storms. These events directly impact the health, housing, safety, business development, and economies of communities and frequently recur in seasonal cycles. Beyond short-term cycles of emergency response, state and local governments are seeking to improve their understanding and address current risks, while improving their overall preparedness for future disasters. NOAA RISA teams are place-based science teams that provide support for planning and preparedness, with expertise in regional risks, local context, institutions, and approaches. These teams partner with decision-makers across multiple private and public sector organizations in their regions, including emergency managers, utilities, ports, small- and medium-sized businesses, rural towns, city planners, and regional councils.In FY 2026, the RISA program will solicit proposals for teams in 9 regions of the United States. The proposal should articulate an integrated set of research and partnership activities that will meaningfully advance the resilience and preparedness of states and communities in each designated region. In the proposed projects, applicants sho...