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The purpose of this notice of funding opportunity (NOFO) is to support translational and clinical research to (1) advance precision medicine in pregnant women, lactating women, and children through the development of novel tools, models, and other technologies that could have a direct clinical or health impact; (2) enhance the understanding of the underlying mechanisms of drug action, including the role of pediatric ontogeny and the dynamic physiological changes that occur during pregnancy and lactation; and (3) discover and develop novel therapeutics or enhance the usage of existing drugs or drug repurposing for safer and more effective medications in pregnant and lactating women, neonates, and children. The overall goal is to improve safe and effective precision therapeutics for pregnant and lactating women, fetuses, neonates, and children, including those with disabilities.

To support the efforts of States, Tribal governments, and research institutions to promote the domestic maple syrup industry through the following activities: promotion of research and education related to maple syrup production, promotion of natural resource sustainability in the maple syrup industry, market promotion for maple syrup and maple-sap products, Encouragement of owners and operators of privately held land containing species of trees in the genus Acer: to initiate or expand maple-sugaring activities on the land; or to voluntarily make the land available, including by lease or other means, for access by the public for maple-sugaring activities.

This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and if it is not a meritorious application, it will not be funded. This single source NOFO is intended to support a Data Coordinating Center (DCC) to conduct the activities of the Cardiothoracic Surgical Trials Network (CTSN). The DCC will consist of two collaborating components including a Data Management and Analytics Center (DMAC) and a Clinical Coordination Center (CCC). NHLBI strongly encourages multi-PD/PI applications with two PDs/PIs; one PD/PI for the DMAC and one PD/PI for the CCC. The primary responsibility of the DCC is to oversee the conduct of multiple randomized clinical trials in the CTSN.The DCC will support regulatory and administrative activities, data collection and management, and statistical analysis and reporting of trial results in a timely manner. The DCC will promote collaboration and communication among CTSN investigators and the broader research community and will coordinate outreach activities including engaging foundations, research entities, and small businesses in trials of mutual interest and public health importance. The DCC is responsible for integrating the efforts of clinical sites, core laboratories, and other collaborators, and conducting long-term follow-up centrally via telephone follow-up at the DCC. The NHLBI anticipates that the DCC will....

The Sexual Assault Services Formula Program (SAS Formula Program), per 34 U.S.C. § 12511(a)(1), assists states and territories in providing “intervention, advocacy, accompaniment, support services, and related assistance for adult, youth, and child victims of sexual assault, family and household members of such victims, and those collaterally affected by the victimization, except for the perpetrator of such victimization.”

The National Park Service"s (NPS) Underrepresented Communities Grant Program (URC) is intended to expand listings in the National Register of Historic Places to include communities that are currently underrepresented. URC grants are funded by the Historic Preservation Fund (HPF), and are administered by the NPS. Projects include surveys and nominations of historic sites associated with communities underrepresented in the National Register. Every URC grant project MUST result in at least one new or amended nomination to the National Register of Historic Places.

The mission of the National RBS Program is to ensure the public has a safe, secure, and enjoyable recreational boating experience by implementing programs designed to minimize the loss of life, personal injury, and property damage while cooperating with environmental and national security efforts via cooperative agreements with nonprofit organizations.

Program Description: In coordination with the Bureau of Educational and Cultural Affairs at the U.S. Department of State (State), the U.S. Department of Education (ED) is soliciting applications in support of the administration of the Centers Aligned with Areas for National Need program. This program provides grants to institutions of higher education (IHEs) or consortia of IHEs to address one or more of the following areas of national need by teaching languages of strategic importance to the United States’ national security and economic prosperity, such as Spanish, Portuguese, Italian, Hungarian, Polish, Russian, Czech, Arabic, Swahili, Hausa, Hindi, Urdu, Mandarin, Korean, Japanese, Farsi, Bahasa, Thai, and other languages; providing instruction in fields needed to provide understanding of areas, regions, or countries in which the language is used; supporting research and training in international studies and the international and foreign language aspects of professional and other fields of study; and advancing the national security interests of the United States by providing instruction on critical regions such as Latin America, Europe, Eurasia, Middle East, Africa, and Asia. Assistance Listing Number: 84.015C. Applicants are required to follow the 2025 Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on August 29, 2025 (90 FR 42234) and available at ED 2025 Common Instructions.

The purpose of this award is to fund a Fiscal Year (FY) 2026 Federal-State Partnership for Intercity Passenger Rail – Congressional Directed Spending (CDS) grant for the Washington Union Station Exterior Lighting Upgrade Project (the Project). The Washington Union Station Exterior Lighting Upgrade Project funds Construction and will enhance public safety/security, lighting uniformity, the public experience, and station identity through improvements to the exterior lighting of the historic facade. Lighting will be significantly enhanced at the main entrance elevation facing Columbus Circle and along the exterior colonnade. The main entrance elevation will be illuminated with new, focused light-emitting diode (LED) fixtures mounted to streetlight poles and in-ground up lights, linear lighting at the ziggurats, and discreet spotlights to highlight the statues. The Union Station Redevelopment Corporation (USRC) is the only eligible entity able to apply.

This is a notice of funding opportunity (NOFO) for the BJA FY 2026 Invited to Apply – Pennington County, South Dakota Public Safety Support for the 250th Anniversary Celebration at Mount Rushmore. This opportunity seeks to support law enforcement and public safety activities associated with the July 3, 2026, celebration of the 250th anniversary of the United States at Mount Rushmore. Funding will support the execution of security operations by the Pennington County Sheriff’s Office to ensure the safety and security of attendees and the surrounding community.

The Center for Inherited Disease Research (CIDR) high-throughput genotyping, sequencing and supporting statistical genetics services are designed to aid the identification of genes or genetic modifications that contribute to human health and disease or to enhance existing collections of well-phenotyped specimens in biorepositories by the addition of genotype or next-generation sequence data. The laboratory specializes in genomic services that cannot be efficiently carried out in individual investigator laboratories. CIDR provides the most up-to-date platforms, services and statistical genetic support. This is an NIH-wide initiative that is managed by NHGRI. Information about current services offered can be accessed via: http://www.cidr.jhmi.edu.

Through WaterSMART, the Bureau of Reclamation (Reclamation) leverages Federal and non-Federal funding to work cooperatively with States, Tribes, and local entities as they plan and implement actions to increase water supply and hydropower reliability. The WaterSMART Program demonstrably advances Trump administration priorities, such as those identified in Presidential Executive Order 14154 (January 20, 2025): Unleashing American Energy (E.O. 14154) and Secretarial Order 3418, and aligns with other priorities and requirements, such as those identified in Presidential Executive Order 14332 (August 7, 2025): Improving Oversight in Federal Grantmaking (E.O. 14332). The goal of the WaterSMART Applied Science Grants (ASG) Notice of Funding Opportunity (NOFO) is to invite eligible entities to apply for funding to improve access to and use of hydrologic data, develop and improve water management tools, and improve hydrologic modeling and forecasting capabilities.Water managers and reservoir operators rely on hydrologic data, modeling, and water supply forecasts to make decisions to meet future water demands. Water supply forecasts are estimates of current and future water supplies based on measured basin conditions (e.g., such as the quantity of upstream mountain snowpack). Results from these projects will be used by water managers to increase water supply reliability to meet water delivery requirements (e.g., compacts, decrees, etc.), provide flexibility in water operations to be more resilient during droughts, and enhance water supply forecasts to better predict floods and optimi...

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Era of Hope Scholar Award supports individuals who are early in their careers with significant potential to effect meaningful change in breast cancer. As the Intent of the FY26 BCRP Era of Hope Scholar Award is to recognize creative and innovative individuals rather than projects, the award’s central features include the Principal Investigator’s (PI’s) demonstrated ability to go beyond conventional thinking in their field and the innovative and meaningful contributions that they can make toward ending breast cancer. The Era of Hope Scholar Award requires exceptionally talented scientists that are among “the best and the brightest” in their field(s), with demonstrated experience forming effective partnerships and collaborations and strong potential for future leadership in breast cancer research. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception.Distinctive Features:·        The PI must commit a minimum of 25% level of time and effort during the period of performance to conduct breast cancer research under this award.·        The research team must include two or more breast cancer consumer advocates.

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Clinical Research Extension Award supports research that extends the data collection, follow-up, and analysis of breast cancer clinical studies. The intent of this award mechanism is to increase the clinically relevant impact of breast cancer patient participation in clinical studies by addressing the knowledge lost due to early trial termination, limited patient follow-up, or suboptimal sample and/or data collection and analysis. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception.Distinctive Features:·        The research team must include two or more breast cancer consumer advocates.·        This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Initiating and  Partnering PI) applications by the deadline may result in administrative withdrawal.

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Transformative Breast Cancer Consortium Development Award provides successful applicants the time and resources needed to bring investigators and breast cancer consumer advocates together to establish a consortium framework and conduct preliminary research in support of an application to a future, full BCRP Transformative Breast Cancer Consortium Award (pending availability of funds). All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception.Distinctive Features:·        This is a development award and is a separate award mechanism from the full FY26 BCRP Transformative Breast Cancer Consortium Award (HT942526BCRPTBCCA). For FY26, investigators may be named as Consortium Director on an application submitted to either (but not both) of these award mechanisms.·        Breast cancer consumer advocates must be active participants in the development and execution of the FY26 BCRP TBCCDA.

Summary: The fiscal year 2026 (FY26) Breast Cancer Research Program (BCRP) Breakthrough Award mechanism supports promising research with high potential to lead to or make breakthroughs in breast cancer. All applications must address at least one of the FY26 BCRP overarching challenges or provide adequate justification for exception. Applications must address the challenge in a way that can lead to a breakthrough and have major impact. The FY26 Breakthrough Award mechanism contains four different funding levels designed to support major (but not all) stages of research that will lead to clinical application. Each level specifies a distinct research scope. This program announcement discusses the Breakthrough Award Levels 1 and 2.Distinctive Features:·        This funding mechanism allows for applications submitted under Funding Level 1 or Funding Level 2. Funding Level 2 also includes a Population Science Studies option. With compelling justification, population science studies may request higher levels of funding and an additional year in the period of performance.·        This funding mechanism allows for a single Principal Investigator (PI), or two partnering PIs referred to as the Initiating PI and the Partnering PI. For the Partnering PI Option (PPIO), only the Initiating PI will submit a pre-application, but both PIs will need to submit at the full application stage. Be advised, failure to submit all associated (Initiating and Partnering PI) applications by the deadline may result in administrative withdrawal.

Description: RTL is designed to: (1) promote school readiness and academic achievement through the development and dissemination of accessible instructional programming for preschool and elementary school children and their families; (2) develop and disseminate programming and digital content containing Ready to Learn programming that is specially designed for nationwide distribution over public television stations’ digital broadcasting channels and the Internet; and (3) Produce educational outreach materials and programs that are designed to deepen and extend the effectiveness of the educational television and interactive. RTL accomplishes this by providing grants to support the creation of nationally distributed educational media content that meets the highest standards of educational quality. RTL television and digital media products focus on developmentally appropriate curriculum frameworks that align with widely accepted learning standards. 

This is a notice of funding opportunity (NOFO) for the OVC FY 2026 Victims of Crime Act (VOCA) Victim Assistance Formula Grant. This opportunity provides an annual VOCA victim assistance grant to all states and most territories to provide subgrants to local organizations and public agencies that provide services directly to crime victims. Examples of services provided include crisis counseling, telephone and onsite information and referrals, criminal justice support and advocacy, shelter, therapy, and additional assistance.

This is a notice of funding opportunity (NOFO) for the OVC FY 2026 Victims of Crime Act (VOCA) Victim Compensation Formula Grant. Eligible victim compensation programs can use these funds to provide crime victims with compensation, support, and services to aid their restoration after criminal violence, including costs associated with medical fees, lost income, dependent care, funeral expenses, and relocation expenses.

The purpose of the Nursing Workforce Development (NWD) program is to increase nursing education opportunities for individuals from disadvantaged backgrounds.

The Telehealth Nutrition Services Network Grant Program will support telehealth networks that improve access to quality health care services through telehealth technology. This program will use telehealth nutrition services to help prevent and manage chronic diseases.

The purpose of this funding opportunity is to award one cooperative agreement recipient to serve as the Evaluation Provider (EP). This funding opportunity has a companion funding opportunity to fund an Implementation Technical Assistance Provider (ITAP). The two recipients will work collaboratively, but conduct distinct activities that support the overall initiative. The proposed initiative will be comprised of one Evaluation Provider (EP), one Implementation Technical Assistance Provider (ITAP) funded as a separate cooperative agreement, and up to eight (8) implementation sites sub-awarded by the ITAP. This initiative will use implementation science to adapt, implement, and evaluate the implementation of interventions that serve men with HIV who are not consistently engaged in care or experiencing barriers to staying in care This initiative directly aligns with Ryan White Program 2030 (RWP2030), which is a renewed vision for the Ryan White HIV/AIDS Program (RWHAP). Building on the foundation of the RWHAP and the Ending the HIV Epidemic in the U.S. initiative, the RWP2030 framework is designed to sustain high-quality care and treatment for people currently receiving services through the RWHAP while expanding efforts to identify and engage individuals with HIV who are undiagnosed or out-of-care. The funded Evaluation Provider (EP) will lead a multi-site evaluation of the project and will provide evaluation-specific technical assistance (TA) to the implementation sites. The evaluation activities that the EP will conduct will draw from frameworks and approaches developed in th...

The purpose of this funding opportunity is to award one cooperative agreement recipient to serve as the Implementation Technical Assistance Provider (ITAP). This funding opportunity has a companion funding opportunity to fund an Evaluation Provider. The two recipients will work collaboratively, but conduct distinct activities that support the overall initiative. The proposed initiative will be comprised of one Implementation Technical Assistance Provider (ITAP), which will sub-award up to eight (8) implementation sites. The funded ITAP will solicit and select the implementation sites, as well as to identify emerging and evidence-informed interventions to be adapted and implemented by the implementation sites. The ITAP will be responsible for managing the subawards and providing implementation-specific technical assistance (TA) for the implementation sites. The proposed initiative will use implementation science to adapt, implement, and evaluate the implementation of interventions that serve men with HIV who are not consistently engaged in care or experiencing barriers to staying in care. This initiative directly aligns with Ryan White Program 2030 (RWP2030), which is a renewed vision for the Ryan White HIV/AIDS Program (RWHAP). Building on the foundation of the RWHAP and the Ending the HIV Epidemic in the U.S. initiative, the RWP2030 framework is designed to sustain high-quality care and treatment for people currently receiving services through the RWHAP while expanding efforts to identify and engage individuals with HIV who are undiagnosed or out-of-care. The funded ITAP w...

The purpose of the Ryan White HIV/AIDS Program (RWHAP) Part C Capacity Development program is to strengthen organizational capacity to increase capacity to develop, enhance, or expand access to high quality HIV primary health care services for low-income people with HIV. The proposed activity should be of a short-term nature and should be completed by the end of the one-year funding opportunity period of performance. Activities fall under two categories: HIV Care Innovation and Infrastructure Development.

Sickle Cell Disease Regional Care Excellence Program (SoRCE) is to improve the health of people with sickle cell disease (SCD) by expanding access to care, improving the quality of care, and tracking quality of life indicators. There are approximately 100,000 people in the United States with SCD. Treatment starting in early childhood can prevent or reduce complications such as severe pain episodes, silent strokes, and premature death. Despite universal identification at birth, fewer than half of children with SCD receive needed treatment. As these children become adolescents and transition to adulthood many are not appropriately identified as candidates for disease-modifying therapies, in part because their doctors are still learning how to use the latest treatments. The program is made up of seven regions with one award recipient per region serving as a Regional Coordinating Hub (RCH). Each award recipient will work with clinical and community-based partners in their region and engage in continuous quality improvement (CQI) initiatives to improve access and quality of care.

​​The Rural Residency Planning and Development (RRPD) program improves and expands rural health care access. It does this by developing new, accredited, sustainable rural residency programs, including rural track programs (RTPs). ​Newly created rural physician residency programs increase training and ultimately practice in rural areas to address physician shortages. ​The RRPD program provides start-up funding to create new rural residency programs in qualifying medical specialties. Long-term sustainability funding must come from viable and stable sources, such as Medicare, Medicaid, and other public or private sources. ​Qualifying medical specialties are:​Family medicine.​Internal medicine.​Preventive medicine.​Psychiatry.​General surgery.​Obstetrics and gynecology.​For this notice of funding opportunity (NOFO), rural residency programs:​Are accredited physician residency programs.​Train residents in clinical training sites that are physically located in a rural area as defined by HRSA"s Federal Office of Rural Health Policy (FORHP) for greater than 50 percent of their total time in residency.​Focus on preparing physicians to practice in rural communities.