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The purpose of the notice of funding opportunity (NOFO) is to solicit applications for a Coccidioidomycosis Collaborative Research Centers (CCRC) program. This new initiative will establish highly collaborative, multi-disciplinary, research teams to conduct translational and clinical research to support the development of a Valley fever vaccine as outlined in NIAID's Strategic Plan for Research to Develop a Valley fever Vaccine.

A.    Background   The overall goal of this project is to improve water quality conditions in Willow Creek Reservoir for the benefit of the community of Heppner, Oregon, and surrounding area. The reservoir is characterized by several water quality concerns, including dense cyanobacteria (or blue-green algae) blooms, low dissolved oxygen concentrations, and high nutrient concentrations. Cyanobacteria blooms are known to produce toxins, thereby threatening the aquatic ecosystem and potentially exposing humans and animals to risk of death or chronic illness such as neurodegeneration and liver damage. Each summer, Willow Creek Reservoir post’s health advisories warning users of the potential hazards associated with recreational activities on the lake. Furthermore, fish kills, foul odors and other nuisances are common in Willow Creek Reservoir affecting the community’s ambiance, limiting tourism and recreation on the lake.   This analysis draws upon prior research, readily available data, and new research and data to develop and implement an evaluation program for the restoration of Willow Creek Reservoir and its upper basin. Research results will provide public benefit through enhanced water quality in Willow Creek Reservoir producing public recreation opportunities and natural resource benefits. B.    Program Description/Objective   The primary objective is to advance the scientific understanding of reservoir ecology through the following research pillars: 1.   Empirical Data Acquisition and Limnological Analysis: To maintain the integrity of high-resolution, longitudinal data...

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program.

This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invites an application from an eligible organization to apply. Please see Section III. Eligibility for additional information. The NHLBI is announcing its intent to issue a single source cooperative agreement to Northwestern University. This NOFO solicits a renewal of the Data Translation Center for an ongoing NHLBI phenomics program, HeartShare, to coordinate the overall project, continue to oversee enrollment of a cohort of patients with heart failure with preserved ejection fraction (HFpEF), curate and analyze prospective deep phenotyping data, and support planning, implementation, and data analysis for clinical trials. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.Companion NOFO RFA-HL-27-008 will support Clinical Centers for recruitment and follow-up of heart failure patients and a Clinical Trial Center for new clinical trial activities.

The Office of International Religious Freedom (IRF) announces an open competition for organizations interested in submitting applications for projects that improve documentation and reporting efforts on religious freedom abuses in Nigeria, for the purposes of accountability, advocacy, and memorialization.

The Office of International Religious Freedom (IRF) announces an open competition for organizations interested in submitting applications for projects that support Nigeria’s legal community to defend religious freedom and constructively engage state actors on cases involving religious freedom violations, including violations of mutually reinforcing rights, such as the freedoms of association, assembly, expression, and movement.

The U.S. Geological Survey (USGS) is offering a funding opportunity to a CESU partner for research focused on developing authoritative knowledge infrastructure for the GeoAI: Application, which will deploy agentic technology to support the Intelligent National Map (INM).

This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. Only current award recipients will be eligible to apply. This NOFO seeks linked collaborative U01 applications to renew the current Adolescent Brain Cognitive Development (ABCD) Research Project Sites to extend study visits into young adulthood. This renewal, called Adolescent Brain Cognitive Development – Extended (ABCD-E) study, is critical to be able to follow these youth into emerging adulthood, when many of the outcomes of interest (e.g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The structure of the ABCD-E study Consortium shall consist of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single central Data Analysis, Informatics, and Resource Center, and (3) a single overall Coordinating Center. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for two centers (RFA-DA-27-003). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. Only current award recipients will be eligible to apply. This NOFO seeks two separate U24 applications to renew the Adolescent Brian Cognitive Development (ABCD) Research Coordinating Center (CC) and the Data Analysis Informatics and Resource Center (DAIRC) to extend study visits into young adulthood. This renewal called Adolescent Brain Cognitive Development – Extended (ABCD-E) study is critical to be able to follow these youth through their emerging adulthood, when many of the outcomes of interest (e.g., substance use disorders, mental health disorders, chronic diseases, and other health conditions) will manifest. The structure of the ABCD-E study Consortium shall consist of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single central Data Analysis, Informatics, and Resource Center, and (3) a single overall Coordinating Center. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for research project sites (RFA-DA-27-002). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

The Arctic Exchange Program (AEP) aims to advance economic prosperity in the United States (Alaska), Canada, and Greenland through short-term exchange activities focused on two overarching themes: Arctic tourism development and critical minerals supply chain resilience. The AEP will consist of three targeted exchange activities with distinct cohorts of approximately eight to 10 participants each. One activity will take place in each participating country, subject to local conditions. The scope of these activities may vary based on program needs. Across all three exchange activities, the AEP will build participants’ professional capacity and create new partnership opportunities that advance economic prosperity in the United States, Canada, and Greenland. The program will position the United States as a partner of choice in Arctic economic development initiatives, promote U.S. business interests, and counter adversarial influence in this strategically important region.Please see the Notice of Funding Opportunity for additional information.

The Global Leaders Division in the Office of Citizen Exchanges at the U.S. Department of State’s Bureau of Educational and Cultural Affairs (ECA) seeks proposals for a cooperative agreement to design and implement the FY 2026 Community Engagement Exchange (CEE). CEE is a two-way exchange initiative for approximately 30-40 emerging civic leaders (ages 22-27), from Europe and Eurasia, that provides skill-based training, hands-on activities, and practical application of one of the First Amendment’s most fundamental rights: the freedom of speech. Grounded in the enduring principles of the U.S. Constitution, CEE equips participants with the skills to promote free speech, reduce conflict and strengthen community engagement. CEE participants will work alongside American counterparts in a substantive six- to eight-week exchange program, including a four-to five-week individually tailored professional placement in a U.S. organization, designed to cultivate practical First Amendment (1A) skills. Approximately 15–20 Americans will travel on reciprocal visits, co-designed with CEE participants, that showcase America’s leadership, promote free speech, and create opportunities for sustained collaboration. CEE advances U.S. foreign policy by strengthening the free speech and community engagement, promoting constructive public discourse, and fostering international partners equipped to address complex challenges in alignment with U.S. interests. CEE is supported by Pawel Adamowicz supplemental funding. Please see the Notice of Funding Opportunity for additional information.

Objective:The aim of the support is to create and operate a network of cinemas with a view to:Encourage cinema operators to screen a significant proportion of non- national European films through incentives and collaborative projects;Contribute to raise and increase the interest of the audience for non-national films including through the development of activities for young cinema-goers;Help those cinemas to adapt their strategy to the changing environment including by promoting innovative approaches in terms of audience reach and engagement, as well as partnerships with other film industry operators as well as with local cultural institutions;Encourage exchange of best practices, knowledge sharing and other forms of cross border collaboration amongst members of the network Contribute to the policy dialogue on the film industry by collecting data and disseminating the outcome of the acti...

The Office of International Religious Freedom (IRF) announces an open competition for organizations interested in submitting applications for projects that support Nigeria’s legal community to defend religious freedom and constructively engage state actors on cases involving religious freedom violations, including violations of mutually reinforcing rights, such as the freedoms of association, assembly, expression, and movement.

The Office of International Religious Freedom (IRF) announces an open competition for organizations interested in submitting applications for projects that improve documentation and reporting efforts on religious freedom abuses in Nigeria, for the purposes of accountability, advocacy, and memorialization.

The purpose of this notice of funding opportunity (NOFO) is to support applications for the Tuberculosis (TB) Research Advancement Centers (TRACs) program. The goal of the TRACs is to develop the next generation of TB researchers and to catalyze multidisciplinary and innovative TB science by providing expertise and resources to facilitate basic and clinical TB research.

This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidisciplinary program titled "Accelerating Product Excellence in Innovation and for Clinical Adoption" (APEx), that will facilitate advancement of promising strategies and products for tissue engineering and regenerative medicine (TE/RM). APEx will be composed of Resource Centers (RCs) and associated Interdisciplinary Translational Projects (ITPs) in the area of therapeutics (including adult stem cell-based treatments), sensors, and diagnostics. RCs will capitalize on their available clinical, scientific, industrial, regulatory and commercialization expertise, to deliver technical support, research capacity, administrative infrastructure and regulatory and commercialization support to the ITPs and guide them to complete pre-clinical studies toward initiation of clinical trials. During this funding cycle, APEx will complete validation, manufacturing, and preclinical testing of the most promising products, which may include, but are not limited to products for detecting or treating tissue damage caused by congenital defect, traumatic injury, or chronic disease. Products that support early detection of chronic pathologies, monitoring of validated biomarkers of health or disease, as well as approaches to reduce or prevent resulting damage, are especially encouraged. The outcome of APEx will be TE/RM products with their regulatory approvals in place for first-in-human studies, along with associated clinical study protocols, and synthesis and manufacturing protocols rea...

ECA announces an open competition for a cooperative agreement to develop and implement a program that will convene cultural ministers from key countries at an iconic location in the United States for high level discussions on cultural heritage and cultural property protection as part of the State Department’s programming to mark America’s 250th birthday. The implementing partner will work closely with ECA to develop the program’s one-to-two-day exchange agenda, including showcasing innovation and new technologies of the U.S. private sector and other American institutions in the cultural heritage field; strengthening cooperation in combatting art and antiquities trafficking; and using cultural heritage to amplify global narratives on America’s foundational values. The convening will feature U.S. models, standards, and best practices; strengthen relationships with key countries in the cultural heritage field; and produce concrete follow-on steps to advance the program’s agenda. Two to three virtual sessions with working level representatives of the selected cultural ministers will precede the U.S. program, helping gain input into and solidify the agenda. Participants will include 25-40 cultural ministers or equivalents/designees from select countries; representatives from the U.S. government, U.S. companies and other institutions involved in cultural heritage preservation and protection; and U.S. law enforcement focused on combatting art and antiquities trafficking. The program will introduce the foreign participants to U.S. advancements in cultural property protection and pr...

The Federal Transit Administration (FTA) announces the opportunity to apply for approximately $28.5 million in Fiscal Year (FY) 2026 funding. The Pilot Program for TOD Planning helps support FTA’s mission of improving public transportation for America’s communities by providing funding to local communities to integrate land use and transportation planning around a new fixed guideway or core capacity improvement project. Per statute, any comprehensive or site specific planning funded through the program must examine ways to improve economic development and ridership, foster multimodal connectivity and accessibility, improve transit access for pedestrian and bicycle traffic, engage the private sector, identify infrastructure needs, and enable mixed-use development near transit stations.

The purpose of the NINDS Child Neurology Career Development Program (CNCDP) is to facilitate and support the research career development of physicians specialized in Child Neurology who have made a commitment to independent research careers. The CNCDP is a single national program, implemented by one or more PD/PIs, together with an advisory committee composed of basic and clinical investigators who have a strong record of funded research and successful training of physicianscientists. The CNCDP will generally provide three consecutive years of support to individuals to provide them with the knowledge, tools and research experience that will enable them to develop a significant research project funded by an individual career development award or research grant.

This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Recruitment Sites (RS) to enroll people with Acute Kidney Injuries (AKI) and/or Chronic Kidney Diseases (CKD) into a longitudinal biopsy cohort study. Under-enrolled populations (e.g., AKI) and comprehensive phenotyping remain priorities. New opportunities include clinical biopsies with residual tissue for research, enhanced physiologic phenotyping, repeat biopsies, pediatric recruitment, and collection of healthy reference tissue. All KPMP personnel will actively participate in scientific discovery and promote open science.

This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Tissue Interrogation Sites (TIS) to use highly integrated multi-modal analytic pipelines to interrogate human kidney biopsy tissue to discover and define new disease pathways and subgroups that enable precision clinical trials. All KPMP personnel will actively participate in scientific discovery and promote open science.

This Notice of Funding Opportunity (NOFO) requests applications for the Kidney Precision Medicine Project (KPMP) Central Hub (CH) to lead a unified effort to discover and define new acute and chronic kidney disease pathways and subgroups that enable precision clinical trials. The CH will provide strategic leadership for the entire KPMP and steward advanced computational analyses, data management and sharing, communication and outreach, and business operations to realize the vision of the KPMP. All KPMP personnel will actively participate in scientific discovery and promote open science.

The STOP Formula program provides grants to states and territories for use by state, local, and Indian Tribal governments, courts, and victim service providers for the more widespread apprehension, prosecution, and adjudication of persons committing violent crimes against women and for the protection and safety of victims.

​​The Pediatric Mental Health Care Access (PMHCA) program helps improve mental and behavioral health for children and youth by giving pediatric primary care providers quick access to tele-consultation, training, and care coordination support.

The purpose of the LEND program is to improve the quality of care for children and youth with autism/developmental disabilities (DD) by training health and related professionals to meet their needs across the lifespan. LEND programs train health and other professionals to screen, diagnose, and provide services for children and youth with autism/DD.